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Protein

Large subunit GTPase 1 homolog

Gene

Lsg1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi212 – 215GTPSequence analysis4
Nucleotide bindingi390 – 397GTPSequence analysis8
Nucleotide bindingi434 – 437GTPSequence analysis4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Large subunit GTPase 1 homolog (EC:3.6.1.-)
Gene namesi
Name:Lsg1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi1309089 Lsg1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003245561 – 655Large subunit GTPase 1 homologAdd BLAST655

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei93PhosphoserineBy similarity1
Modified residuei97PhosphoserineBy similarity1
Modified residuei252PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5BJT6
PRIDEiQ5BJT6

Expressioni

Gene expression databases

BgeeiENSRNOG00000001727
GenevisibleiQ5BJT6 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002354

Structurei

3D structure databases

ProteinModelPortaliQ5BJT6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini164 – 441CP-type GPROSITE-ProRule annotationAdd BLAST278

Domaini

In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.

Sequence similaritiesi

Belongs to the TRAFAC class YlqF/YawG GTPase family. LSG1 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1424 Eukaryota
COG1161 LUCA
GeneTreeiENSGT00530000063453
HOGENOMiHOG000172552
HOVERGENiHBG097657
InParanoidiQ5BJT6
KOiK14539
OMAiYNRGFMT
PhylomeDBiQ5BJT6
TreeFamiTF105747

Family and domain databases

InterProiView protein in InterPro
IPR030378 G_CP_dom
IPR006073 GTP_binding_domain
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01926 MMR_HSR1, 1 hit
PRINTSiPR00326 GTP1OBG
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51721 G_CP, 1 hit

Sequencei

Sequence statusi: Complete.

Q5BJT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRRRAPGGG SLGRVLIRHQ TQRSRSHRHT DSWLHTSELN DGYDWGRLNL
60 70 80 90 100
QSVTEQSSLE DFLATAELAG TEFVAEKLNI KFVPPEARTG LLSFEESQRI
110 120 130 140 150
KRLHEENRQF LCIPRRPNWD RKTSPEELKQ AEKDNFLKWR RQLVRLEEEQ
160 170 180 190 200
KLILTPFERN LDFWRQLWRV IERSDIVVQI VDARNPLLFR CEDLECYVKE
210 220 230 240 250
IDAAKENVIL INKADLLTAE QRVAWAVHFE KEGVKVIFWS ALAETVHLNG
260 270 280 290 300
DSKDEVNSVA GEANSSESED SSLDGNEIPH RDLFLLSEES ESDDDDSEYE
310 320 330 340 350
DCQEDEEEDW QTCSEEDSNP EEGQEEGGCD RDQKEHGPED SEAQSRASPE
360 370 380 390 400
NSQMSNKSHL VSKQELLELF KKLHTGKKVK DGQLTVGLVG YPNVGKSSTI
410 420 430 440 450
NTIMGNKKVS VSATPGHTKH FQTLYVEPGL CLCDCPGLVM PSFVSTKAEM
460 470 480 490 500
ICSGILPIDQ MRDHVPPVSL VCQNIPRRVL EATYGINIIK PGEDEDPYRP
510 520 530 540 550
PTSEELLTAY GCMRGFMTAH GQPDQPRSAR YILKDYVRGK LLYCHPPPGK
560 570 580 590 600
DPVAFQHQHR QLLENKIKGE ELRLQPGKTQ KAKQVENVVD KTFFHQENVR
610 620 630 640 650
ALTKGVQAVM GYKPGSGLVT AAAASAENVP GKPWKKHGNR NKKEKSRRLY

RHLDV
Length:655
Mass (Da):74,403
Last modified:April 12, 2005 - v1
Checksum:iF91E42DDC58BE407
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091338 mRNA Translation: AAH91338.1
RefSeqiNP_001013439.1, NM_001013421.1
UniGeneiRn.41256

Genome annotation databases

EnsembliENSRNOT00000002354; ENSRNOP00000002354; ENSRNOG00000001727
ENSRNOT00000081081; ENSRNOP00000074962; ENSRNOG00000001727
ENSRNOT00000090940; ENSRNOP00000071302; ENSRNOG00000001727
GeneIDi288029
KEGGirno:288029
UCSCiRGD:1309089 rat

Similar proteinsi

Entry informationi

Entry nameiLSG1_RAT
AccessioniPrimary (citable) accession number: Q5BJT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: April 12, 2005
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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