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Protein

Large subunit GTPase 1 homolog

Gene

Lsg1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi212 – 2154GTPSequence analysis
Nucleotide bindingi390 – 3978GTPSequence analysis
Nucleotide bindingi434 – 4374GTPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Large subunit GTPase 1 homolog (EC:3.6.1.-)
Gene namesi
Name:Lsg1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi1309089. Lsg1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 655655Large subunit GTPase 1 homologPRO_0000324556Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei93 – 931PhosphoserineBy similarity
Modified residuei97 – 971PhosphoserineBy similarity
Modified residuei252 – 2521PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5BJT6.
PRIDEiQ5BJT6.

Expressioni

Gene expression databases

BgeeiENSRNOG00000001727.
GenevisibleiQ5BJT6. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002354.

Structurei

3D structure databases

ProteinModelPortaliQ5BJT6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini164 – 441278CP-type GPROSITE-ProRule annotationAdd
BLAST

Domaini

In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.

Sequence similaritiesi

Belongs to the TRAFAC class YlqF/YawG GTPase family. LSG1 subfamily.PROSITE-ProRule annotation
Contains 1 CP-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1424. Eukaryota.
COG1161. LUCA.
GeneTreeiENSGT00530000063453.
HOGENOMiHOG000172552.
HOVERGENiHBG097657.
InParanoidiQ5BJT6.
KOiK14539.
OMAiEDDWQTC.
PhylomeDBiQ5BJT6.
TreeFamiTF105747.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR030378. G_CP_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51721. G_CP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5BJT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRRRAPGGG SLGRVLIRHQ TQRSRSHRHT DSWLHTSELN DGYDWGRLNL
60 70 80 90 100
QSVTEQSSLE DFLATAELAG TEFVAEKLNI KFVPPEARTG LLSFEESQRI
110 120 130 140 150
KRLHEENRQF LCIPRRPNWD RKTSPEELKQ AEKDNFLKWR RQLVRLEEEQ
160 170 180 190 200
KLILTPFERN LDFWRQLWRV IERSDIVVQI VDARNPLLFR CEDLECYVKE
210 220 230 240 250
IDAAKENVIL INKADLLTAE QRVAWAVHFE KEGVKVIFWS ALAETVHLNG
260 270 280 290 300
DSKDEVNSVA GEANSSESED SSLDGNEIPH RDLFLLSEES ESDDDDSEYE
310 320 330 340 350
DCQEDEEEDW QTCSEEDSNP EEGQEEGGCD RDQKEHGPED SEAQSRASPE
360 370 380 390 400
NSQMSNKSHL VSKQELLELF KKLHTGKKVK DGQLTVGLVG YPNVGKSSTI
410 420 430 440 450
NTIMGNKKVS VSATPGHTKH FQTLYVEPGL CLCDCPGLVM PSFVSTKAEM
460 470 480 490 500
ICSGILPIDQ MRDHVPPVSL VCQNIPRRVL EATYGINIIK PGEDEDPYRP
510 520 530 540 550
PTSEELLTAY GCMRGFMTAH GQPDQPRSAR YILKDYVRGK LLYCHPPPGK
560 570 580 590 600
DPVAFQHQHR QLLENKIKGE ELRLQPGKTQ KAKQVENVVD KTFFHQENVR
610 620 630 640 650
ALTKGVQAVM GYKPGSGLVT AAAASAENVP GKPWKKHGNR NKKEKSRRLY

RHLDV
Length:655
Mass (Da):74,403
Last modified:April 12, 2005 - v1
Checksum:iF91E42DDC58BE407
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091338 mRNA. Translation: AAH91338.1.
RefSeqiNP_001013439.1. NM_001013421.1.
UniGeneiRn.41256.

Genome annotation databases

EnsembliENSRNOT00000002354; ENSRNOP00000002354; ENSRNOG00000001727.
ENSRNOT00000081081; ENSRNOP00000074962; ENSRNOG00000001727.
ENSRNOT00000090940; ENSRNOP00000071302; ENSRNOG00000001727.
GeneIDi288029.
KEGGirno:288029.
UCSCiRGD:1309089. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091338 mRNA. Translation: AAH91338.1.
RefSeqiNP_001013439.1. NM_001013421.1.
UniGeneiRn.41256.

3D structure databases

ProteinModelPortaliQ5BJT6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002354.

Proteomic databases

PaxDbiQ5BJT6.
PRIDEiQ5BJT6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000002354; ENSRNOP00000002354; ENSRNOG00000001727.
ENSRNOT00000081081; ENSRNOP00000074962; ENSRNOG00000001727.
ENSRNOT00000090940; ENSRNOP00000071302; ENSRNOG00000001727.
GeneIDi288029.
KEGGirno:288029.
UCSCiRGD:1309089. rat.

Organism-specific databases

CTDi55341.
RGDi1309089. Lsg1.

Phylogenomic databases

eggNOGiKOG1424. Eukaryota.
COG1161. LUCA.
GeneTreeiENSGT00530000063453.
HOGENOMiHOG000172552.
HOVERGENiHBG097657.
InParanoidiQ5BJT6.
KOiK14539.
OMAiEDDWQTC.
PhylomeDBiQ5BJT6.
TreeFamiTF105747.

Miscellaneous databases

PROiQ5BJT6.

Gene expression databases

BgeeiENSRNOG00000001727.
GenevisibleiQ5BJT6. RN.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR030378. G_CP_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51721. G_CP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLSG1_RAT
AccessioniPrimary (citable) accession number: Q5BJT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: April 12, 2005
Last modified: September 7, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.