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Protein
Submitted name:

Itpr1 protein

Gene

Itpr1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium channel inhibitor activity Source: Ensembl
  2. intracellular ligand-gated calcium channel activity Source: Ensembl
  3. phosphatidylinositol binding Source: Ensembl

GO - Biological processi

  1. endoplasmic reticulum calcium ion homeostasis Source: Ensembl
  2. intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: Ensembl
  3. negative regulation of calcium-mediated signaling Source: Ensembl
  4. post-embryonic development Source: Ensembl
  5. release of sequestered calcium ion into cytosol Source: Ensembl
  6. response to hypoxia Source: Ensembl
  7. voluntary musculoskeletal movement Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_297045. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_338751. Elevation of cytosolic Ca2+ levels.
REACT_341785. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_349609. cGMP effects.
REACT_351116. Effects of PIP2 hydrolysis.

Names & Taxonomyi

Protein namesi
Submitted name:
Itpr1 proteinImported
Gene namesi
Name:Itpr1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi2933. Itpr1.

Subcellular locationi

GO - Cellular componenti

  1. calcineurin complex Source: Ensembl
  2. endoplasmic reticulum membrane Source: Ensembl
  3. nuclear inner membrane Source: Ensembl
  4. nucleolus Source: Ensembl
  5. platelet dense granule membrane Source: Ensembl
  6. platelet dense tubular network Source: Ensembl
  7. postsynaptic density Source: Ensembl
  8. sarcoplasmic reticulum Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiQ5BJS8. baseline and differential.
GenevestigatoriQ5BJS8.

Interactioni

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000007660.
KOiK04958.

Family and domain databases

InterProiIPR015925. Ryanodine_recept-rel.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q5BJS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
FEEHIKEEHN MWHYLCFIVL VKVKDSTEYT GPESYVAEMI RERNLDWFPR
60 70 80 90 100
MRAMSLVSSD SEGEQNELRN LQEKLESTMK LVTNLSGQLS ELKDQMTEQR
110 120
KQKQRIGLLG HPPHMNVNPQ QPA
Length:123
Mass (Da):14,484
Last modified:April 12, 2005 - v1
Checksum:i50C33E512B23DC62
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091346 mRNA. Translation: AAH91346.1.
RefSeqiNP_001007236.2. NM_001007235.2.
NP_001257525.1. NM_001270596.1.
NP_001257526.1. NM_001270597.1.
UniGeneiRn.2135.

Genome annotation databases

GeneIDi25262.
KEGGirno:25262.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091346 mRNA. Translation: AAH91346.1.
RefSeqiNP_001007236.2. NM_001007235.2.
NP_001257525.1. NM_001270596.1.
NP_001257526.1. NM_001270597.1.
UniGeneiRn.2135.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ5BJS8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25262.
KEGGirno:25262.

Organism-specific databases

CTDi3708.
RGDi2933. Itpr1.

Phylogenomic databases

HOGENOMiHOG000007660.
KOiK04958.

Enzyme and pathway databases

ReactomeiREACT_297045. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_338751. Elevation of cytosolic Ca2+ levels.
REACT_341785. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_349609. cGMP effects.
REACT_351116. Effects of PIP2 hydrolysis.

Gene expression databases

ExpressionAtlasiQ5BJS8. baseline and differential.
GenevestigatoriQ5BJS8.

Family and domain databases

InterProiIPR015925. Ryanodine_recept-rel.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.

Entry informationi

Entry nameiQ5BJS8_RAT
AccessioniPrimary (citable) accession number: Q5BJS8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 12, 2005
Last sequence update: April 12, 2005
Last modified: April 1, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.