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Protein

Retinoic acid receptor RXR-gamma

Gene

Rxrg

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi139 – 204Nuclear receptorPROSITE-ProRule annotationAdd BLAST66
Zinc fingeri139 – 159NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri175 – 199NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

  • cellular response to hormone stimulus Source: RGD
  • heart development Source: RGD
  • neuron differentiation Source: RGD
  • peripheral nervous system development Source: RGD
  • regulation of myelination Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to retinoic acid Source: RGD
  • skeletal muscle tissue development Source: RGD
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-383280. Nuclear Receptor transcription pathway.
R-RNO-5362517. Signaling by Retinoic Acid.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinoic acid receptor RXR-gamma
Alternative name(s):
Nuclear receptor subfamily 2 group B member 3
Retinoid X receptor gamma
Gene namesi
Name:Rxrg
Synonyms:Nr2b3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi620046. Rxrg.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4277.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003170321 – 463Retinoic acid receptor RXR-gammaAdd BLAST463

Proteomic databases

PaxDbiQ5BJR8.

PTM databases

PhosphoSitePlusiQ5BJR8.

Expressioni

Tissue specificityi

Resticted expression in adrenal gland, kidney, liver, brain and lungs. Strong expression in heart and lungs.1 Publication

Gene expression databases

BgeeiENSRNOG00000004537.
ExpressionAtlasiQ5BJR8. baseline and differential.
GenevisibleiQ5BJR8. RN.

Interactioni

Subunit structurei

Homodimer. Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006117.

Chemistry databases

BindingDBiQ5BJR8.

Structurei

3D structure databases

ProteinModelPortaliQ5BJR8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 138ModulatingBy similarityAdd BLAST138
Regioni205 – 260HingeAdd BLAST56
Regioni261 – 463Ligand-bindingBy similarityAdd BLAST203

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri139 – 159NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri175 – 199NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00760000118948.
HOGENOMiHOG000260821.
HOVERGENiHBG005606.
InParanoidiQ5BJR8.
KOiK08526.
PhylomeDBiQ5BJR8.
TreeFamiTF352097.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR021780. Nuc_recep-AF1.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR000003. Retinoid-X_rcpt/HNF4.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF11825. Nuc_recep-AF1. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00545. RETINOIDXR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5BJR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYGNYSHFMK FPTGFGGSPG HTGSTSMSPS VALPTGKPMD SHPSYTDTPV
60 70 80 90 100
SAPRTLSAVG TPLNALGSPY RVITSAMGPP SGALAAPPGI NLVVPPSSQL
110 120 130 140 150
NVVNSVSSSE DIKPLPGLPG IGNMNYPSTS PGSLVKHICA ICGDRSSGKH
160 170 180 190 200
YGVYSCEGCK GFFKRTIRKD LIYTCRDNKD CLIDKRQRNR CQYCRYQKCL
210 220 230 240 250
VMGMKREAVQ EERQRSRERA ESEAECASTG HEDMPVERIL EAELAVEPKT
260 270 280 290 300
ESYGDMSVES STNDPVTNIC HAADKQLFTL VEWAKRIPHF SDLTLEDQVI
310 320 330 340 350
LLRAGWNELL IASFSHRSVS VQDGILLATG LHVHRSSAHS AGVGSIFDRV
360 370 380 390 400
LTELVSKMKD MRMDKSELGC LRAIVLFNPD AKGLSNPSEV ETLREKVYAT
410 420 430 440 450
LEAYTKQKYP EQPGRFAKLL LRLPALRSIG LKCLEHLFFF KLIGDTPIDT
460
FLMEMLETPL QIT
Length:463
Mass (Da):50,893
Last modified:April 12, 2005 - v1
Checksum:i1D3A6607A068C837
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091363 mRNA. Translation: AAH91363.1.
RefSeqiNP_113953.1. NM_031765.1.
UniGeneiRn.40816.

Genome annotation databases

EnsembliENSRNOT00000006117; ENSRNOP00000006117; ENSRNOG00000004537.
GeneIDi83574.
KEGGirno:83574.
UCSCiRGD:620046. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091363 mRNA. Translation: AAH91363.1.
RefSeqiNP_113953.1. NM_031765.1.
UniGeneiRn.40816.

3D structure databases

ProteinModelPortaliQ5BJR8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006117.

Chemistry databases

BindingDBiQ5BJR8.
ChEMBLiCHEMBL4277.

PTM databases

PhosphoSitePlusiQ5BJR8.

Proteomic databases

PaxDbiQ5BJR8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006117; ENSRNOP00000006117; ENSRNOG00000004537.
GeneIDi83574.
KEGGirno:83574.
UCSCiRGD:620046. rat.

Organism-specific databases

CTDi6258.
RGDi620046. Rxrg.

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00760000118948.
HOGENOMiHOG000260821.
HOVERGENiHBG005606.
InParanoidiQ5BJR8.
KOiK08526.
PhylomeDBiQ5BJR8.
TreeFamiTF352097.

Enzyme and pathway databases

ReactomeiR-RNO-383280. Nuclear Receptor transcription pathway.
R-RNO-5362517. Signaling by Retinoic Acid.

Miscellaneous databases

PROiQ5BJR8.

Gene expression databases

BgeeiENSRNOG00000004537.
ExpressionAtlasiQ5BJR8. baseline and differential.
GenevisibleiQ5BJR8. RN.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR021780. Nuc_recep-AF1.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR000003. Retinoid-X_rcpt/HNF4.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF11825. Nuc_recep-AF1. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00545. RETINOIDXR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRXRG_RAT
AccessioniPrimary (citable) accession number: Q5BJR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: April 12, 2005
Last modified: November 2, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.