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Protein

Transcriptional adapter 1

Gene

Tada1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probably involved in transcriptional regulation.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional adapter 1
Alternative name(s):
Transcriptional adapter 1-like protein
Gene namesi
Name:Tada1
Synonyms:Tada1l
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi1306774. Tada1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 335335Transcriptional adapter 1PRO_0000316018Add
BLAST

Proteomic databases

PaxDbiQ5BJQ7.

PTM databases

PhosphoSiteiQ5BJQ7.

Expressioni

Gene expression databases

ExpressionAtlasiQ5BJQ7. baseline and differential.
GenevisibleiQ5BJQ7. RN.

Interactioni

Subunit structurei

Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005090.

Family & Domainsi

Sequence similaritiesi

Belongs to the TADA1 family.Curated

Phylogenomic databases

eggNOGiENOG410IJ0B. Eukaryota.
ENOG4111F9I. LUCA.
GeneTreeiENSGT00390000011644.
HOGENOMiHOG000035120.
HOVERGENiHBG099848.
InParanoidiQ5BJQ7.
KOiK11317.
OMAiEARMMVT.
OrthoDBiEOG7H4DVH.
PhylomeDBiQ5BJQ7.
TreeFamiTF324330.

Family and domain databases

InterProiIPR024738. Hfi1/Tada1.
[Graphical view]
PfamiPF12767. SAGA-Tad1. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5BJQ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATFVSELEA AKKNLSEALG DNVKQYWANL KLWFKQKISK EEFDLEAHRL
60 70 80 90 100
LTQDNVHSHN DFLLAILTRC QILVSTPEGA GSLPWTGGSA AKPGKPKGKK
110 120 130 140 150
KLSSVRQKFD HRFQPQNPLS GAQQFVAKDP QDDDDLKLCS HTMMLPTRGQ
160 170 180 190 200
LEGRMIVTAY EHGLDNVTEE AVSAVVYAVE NHLKDILTSV VSRRKAYRVR
210 220 230 240 250
DGHFKYAFGS NVTPQPYLKN SVVAYNNLVE GPPAFPAPCA SQNPASHPHT
260 270 280 290 300
DDAEQQAAFL LACSGDTLPA SLPPVNMYDL FEALQVHREV IPTHTVYALN
310 320 330
IERIIMKLWH PNHEELQQDK VHRQRLAAKE GLLLC
Length:335
Mass (Da):37,476
Last modified:January 15, 2008 - v2
Checksum:i5F8B6304C58A9C95
GO
Isoform 2 (identifier: Q5BJQ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: Missing.
     93-110: PGKPKGKKKLSSVRQKFD → MISSWPSSHAVRFWFLHQ

Note: No experimental confirmation available.
Show »
Length:243
Mass (Da):27,410
Checksum:i281218BA166561E4
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9292Missing in isoform 2. 1 PublicationVSP_030756Add
BLAST
Alternative sequencei93 – 11018PGKPK…RQKFD → MISSWPSSHAVRFWFLHQ in isoform 2. 1 PublicationVSP_030757Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03084751 Genomic DNA. No translation available.
BC091380 mRNA. Translation: AAH91380.1.
RefSeqiNP_001033069.2. NM_001037980.2. [Q5BJQ7-1]
UniGeneiRn.23978.

Genome annotation databases

EnsembliENSRNOT00000058689; ENSRNOP00000055484; ENSRNOG00000003816. [Q5BJQ7-2]
GeneIDi360874.
KEGGirno:360874.
UCSCiRGD:1306774. rat. [Q5BJQ7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03084751 Genomic DNA. No translation available.
BC091380 mRNA. Translation: AAH91380.1.
RefSeqiNP_001033069.2. NM_001037980.2. [Q5BJQ7-1]
UniGeneiRn.23978.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005090.

PTM databases

PhosphoSiteiQ5BJQ7.

Proteomic databases

PaxDbiQ5BJQ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000058689; ENSRNOP00000055484; ENSRNOG00000003816. [Q5BJQ7-2]
GeneIDi360874.
KEGGirno:360874.
UCSCiRGD:1306774. rat. [Q5BJQ7-1]

Organism-specific databases

CTDi117143.
RGDi1306774. Tada1.

Phylogenomic databases

eggNOGiENOG410IJ0B. Eukaryota.
ENOG4111F9I. LUCA.
GeneTreeiENSGT00390000011644.
HOGENOMiHOG000035120.
HOVERGENiHBG099848.
InParanoidiQ5BJQ7.
KOiK11317.
OMAiEARMMVT.
OrthoDBiEOG7H4DVH.
PhylomeDBiQ5BJQ7.
TreeFamiTF324330.

Miscellaneous databases

PROiQ5BJQ7.

Gene expression databases

ExpressionAtlasiQ5BJQ7. baseline and differential.
GenevisibleiQ5BJQ7. RN.

Family and domain databases

InterProiIPR024738. Hfi1/Tada1.
[Graphical view]
PfamiPF12767. SAGA-Tad1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.

Entry informationi

Entry nameiTADA1_RAT
AccessioniPrimary (citable) accession number: Q5BJQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: June 8, 2016
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.