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Protein

GTP-binding protein Rit2

Gene

Rit2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Binds and exchanges GTP and GDP.By similarity

Miscellaneous

Shows rapid uncatalyzed guanine nucleotide dissociation rates, which are much faster than those of most Ras subfamily members.By similarity

Enzyme regulationi

Alternates between an inactive form bound to GDP and an active form bound to GTP.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi27 – 34GTPBy similarity8
Nucleotide bindingi74 – 78GTPBy similarity5
Nucleotide bindingi133 – 136GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

  • maintenance of protein location in cell Source: Ensembl
  • negative regulation of neuron projection development Source: Ensembl
  • positive regulation of adenylate cyclase activity Source: ParkinsonsUK-UCL
  • positive regulation of MAPK cascade Source: ParkinsonsUK-UCL
  • positive regulation of neuron projection development Source: ParkinsonsUK-UCL
  • positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  • Ras protein signal transduction Source: Ensembl
  • regulation of calcium-mediated signaling Source: ParkinsonsUK-UCL
  • regulation of Cdc42 protein signal transduction Source: Ensembl
  • regulation of endocytosis Source: Ensembl
  • regulation of protein phosphorylation Source: ParkinsonsUK-UCL
  • small GTPase mediated signal transduction Source: Reactome

Keywordsi

Molecular functionCalmodulin-binding
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-187706. Signalling to p38 via RIT and RIN.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein Rit2
Gene namesi
Name:Rit2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi1307654. Rit2.

Subcellular locationi

  • Nucleus By similarity
  • Cell membrane By similarity

  • Note: Colocalizes with PLXNB3 at the plasma membrane.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002332611 – 217GTP-binding protein Rit2Add BLAST217

Proteomic databases

PaxDbiQ5BJQ5.
PRIDEiQ5BJQ5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000017568.
GenevisibleiQ5BJQ5. RN.

Interactioni

Subunit structurei

Interacts with AFDN, the C-terminal domain of RALGDS and RLF, but not with RIN1 and PIK3CA. RLF binds exclusively to the active GTP-bound form. Binds calmodulin. Interacts with PLXNB3 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023871.

Structurei

3D structure databases

ProteinModelPortaliQ5BJQ5.
SMRiQ5BJQ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133678.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ5BJQ5.
KOiK07833.
OMAiRFLDYHD.
OrthoDBiEOG091G0UAU.
PhylomeDBiQ5BJQ5.
TreeFamiTF315072.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51421. RAS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5BJQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAENEAHCC PGSSSGGSRE YKVVMLGAGG VGKSAVTMQF ISHQFPDYHD
60 70 80 90 100
PTIEDAYKTQ VRIDNEPAYL DILDTAGQAE FTAMREQYMR GGEGFIICYS
110 120 130 140 150
VTDRQSFQEA AKFKELIFQV RHTYEIPLVL VGNKIDLEQF RQVSTEEGMT
160 170 180 190 200
LARDYNCAFF ETSAALRFGI DDAFQGLVRE IRRKESMLSL VERKLKRKDS
210
LWKKIKASLK KKRENMI
Length:217
Mass (Da):24,761
Last modified:April 12, 2005 - v1
Checksum:i4D12C7B0D3F46903
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091382 mRNA. Translation: AAH91382.1.
RefSeqiNP_001013078.1. NM_001013060.1.
UniGeneiRn.106719.

Genome annotation databases

EnsembliENSRNOT00000023874; ENSRNOP00000023871; ENSRNOG00000017568.
GeneIDi291713.
KEGGirno:291713.
UCSCiRGD:1307654. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRIT2_RAT
AccessioniPrimary (citable) accession number: Q5BJQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: April 12, 2005
Last modified: June 7, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families