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Protein

GTP-binding protein Rit2

Gene

Rit2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds and exchanges GTP and GDP.By similarity

Enzyme regulationi

Alternates between an inactive form bound to GDP and an active form bound to GTP.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi27 – 348GTPBy similarity
Nucleotide bindingi74 – 785GTPBy similarity
Nucleotide bindingi133 – 1364GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calmodulin-binding, GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-187706. Signalling to p38 via RIT and RIN.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein Rit2
Gene namesi
Name:Rit2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi1307654. Rit2.

Subcellular locationi

  • Nucleus By similarity
  • Cell membrane By similarity

  • Note: Colocalizes with PLXNB3 at the plasma membrane.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 217217GTP-binding protein Rit2PRO_0000233261Add
BLAST

Proteomic databases

PaxDbiQ5BJQ5.
PRIDEiQ5BJQ5.

Expressioni

Gene expression databases

GenevisibleiQ5BJQ5. RN.

Interactioni

Subunit structurei

Interacts with MLLT4, the C-terminal domain of RALGDS and RLF, but not with RIN1 and PIK3CA. RLF binds exclusively to the active GTP-bound form. Binds calmodulin. Interacts with PLXNB3 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023871.

Structurei

3D structure databases

ProteinModelPortaliQ5BJQ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121857.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ5BJQ5.
KOiK07833.
OMAiRCGEGFM.
OrthoDBiEOG7QVM41.
PhylomeDBiQ5BJQ5.
TreeFamiTF315072.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5BJQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAENEAHCC PGSSSGGSRE YKVVMLGAGG VGKSAVTMQF ISHQFPDYHD
60 70 80 90 100
PTIEDAYKTQ VRIDNEPAYL DILDTAGQAE FTAMREQYMR GGEGFIICYS
110 120 130 140 150
VTDRQSFQEA AKFKELIFQV RHTYEIPLVL VGNKIDLEQF RQVSTEEGMT
160 170 180 190 200
LARDYNCAFF ETSAALRFGI DDAFQGLVRE IRRKESMLSL VERKLKRKDS
210
LWKKIKASLK KKRENMI
Length:217
Mass (Da):24,761
Last modified:April 12, 2005 - v1
Checksum:i4D12C7B0D3F46903
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091382 mRNA. Translation: AAH91382.1.
RefSeqiNP_001013078.1. NM_001013060.1.
UniGeneiRn.106719.

Genome annotation databases

EnsembliENSRNOT00000023874; ENSRNOP00000023871; ENSRNOG00000017568.
GeneIDi291713.
KEGGirno:291713.
UCSCiRGD:1307654. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091382 mRNA. Translation: AAH91382.1.
RefSeqiNP_001013078.1. NM_001013060.1.
UniGeneiRn.106719.

3D structure databases

ProteinModelPortaliQ5BJQ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023871.

Proteomic databases

PaxDbiQ5BJQ5.
PRIDEiQ5BJQ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000023874; ENSRNOP00000023871; ENSRNOG00000017568.
GeneIDi291713.
KEGGirno:291713.
UCSCiRGD:1307654. rat.

Organism-specific databases

CTDi6014.
RGDi1307654. Rit2.

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121857.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ5BJQ5.
KOiK07833.
OMAiRCGEGFM.
OrthoDBiEOG7QVM41.
PhylomeDBiQ5BJQ5.
TreeFamiTF315072.

Enzyme and pathway databases

ReactomeiR-RNO-187706. Signalling to p38 via RIT and RIN.

Miscellaneous databases

PROiQ5BJQ5.

Gene expression databases

GenevisibleiQ5BJQ5. RN.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiRIT2_RAT
AccessioniPrimary (citable) accession number: Q5BJQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: April 12, 2005
Last modified: June 8, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Shows rapid uncatalyzed guanine nucleotide dissociation rates, which are much faster than those of most Ras subfamily members.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.