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Protein

Zinc transporter 7

Gene

Slc30a7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Transport, Zinc transport
LigandZinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 7
Short name:
ZnT-7
Alternative name(s):
Solute carrier family 30 member 7
Gene namesi
Name:Slc30a7
Synonyms:Znt7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1307873 Slc30a7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37CytoplasmicSequence analysisAdd BLAST37
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Topological domaini59 – 67ExtracellularSequence analysis9
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Topological domaini89 – 102CytoplasmicSequence analysisAdd BLAST14
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Topological domaini124 – 140ExtracellularSequence analysisAdd BLAST17
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Topological domaini162 – 238CytoplasmicSequence analysisAdd BLAST77
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Topological domaini260 – 264ExtracellularSequence analysis5
Transmembranei265 – 285HelicalSequence analysisAdd BLAST21
Topological domaini286 – 378CytoplasmicSequence analysisAdd BLAST93

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003143011 – 378Zinc transporter 7Add BLAST378

Proteomic databases

PaxDbiQ5BJM8
PRIDEiQ5BJM8

Expressioni

Gene expression databases

BgeeiENSRNOG00000013912
GenevisibleiQ5BJM8 RN

Interactioni

Subunit structurei

Homooligomer.By similarity

Protein-protein interaction databases

IntActiQ5BJM8, 1 interactor
STRINGi10116.ENSRNOP00000019172

Structurei

3D structure databases

ProteinModelPortaliQ5BJM8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni161 – 220His-rich loopAdd BLAST60

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1484 Eukaryota
COG1230 LUCA
GeneTreeiENSGT00630000089781
HOGENOMiHOG000018690
HOVERGENiHBG056637
InParanoidiQ5BJM8
KOiK14692
OMAiWKRLIFS
OrthoDBiEOG091G030D
PhylomeDBiQ5BJM8
TreeFamiTF315217

Family and domain databases

Gene3Di1.20.1510.10, 2 hits
InterProiView protein in InterPro
IPR002524 Cation_efflux
IPR027469 Cation_efflux_TMD_sf
PfamiView protein in Pfam
PF01545 Cation_efflux, 1 hit
SUPFAMiSSF161111 SSF161111, 2 hits
TIGRFAMsiTIGR01297 CDF, 1 hit

Sequencei

Sequence statusi: Complete.

Q5BJM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPLSIKDDE YKPPKFNLFG KISGWFRSIL SDKTSRNLFF FLCLNLSFAF
60 70 80 90 100
VELLYGIWSN CLGLISDSFH MFFDSTAILA GLAASVISKW RDNDAFSYGY
110 120 130 140 150
VRAEVLAGFV NGLFLIFTAF FIFSEGVERA LAPPDVHHER LLLVSILGFV
160 170 180 190 200
VNLVGIFVFN HGGHGHSHGS GHGHSHSLFN GALDHSHGHE DHCHSHGAKH
210 220 230 240 250
GGAHSHDHDH AHGHGHLHSH DGPSFKETAG PSRQILQGVF LHILADTLGS
260 270 280 290 300
IGVIASAIMM QNFGLMIADP ICSILIAILI VVSVIPLLRE SIGILMQRTP
310 320 330 340 350
PSLENVLPQC YQRVQQLQGV YNLQEQHFWT LCSDVYVGTL KLVVAPDADA
360 370
RWILSQTHNI FTQAGVRQLY VQIDFAAM
Length:378
Mass (Da):41,774
Last modified:January 15, 2008 - v2
Checksum:iA82E9F3D02E2AF1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BP503381 mRNA No translation available.
BC091417 mRNA Translation: AAH91417.1
BC107441 mRNA Translation: AAI07442.1
RefSeqiNP_001178644.1, NM_001191715.1
UniGeneiRn.105204

Genome annotation databases

EnsembliENSRNOT00000019172; ENSRNOP00000019172; ENSRNOG00000013912
GeneIDi310801
KEGGirno:310801
UCSCiRGD:1307873 rat

Similar proteinsi

Entry informationi

Entry nameiZNT7_RAT
AccessioniPrimary (citable) accession number: Q5BJM8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: March 28, 2018
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health