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Protein

Zinc transporter 7

Gene

Slc30a7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 7
Short name:
ZnT-7
Alternative name(s):
Solute carrier family 30 member 7
Gene namesi
Name:Slc30a7
Synonyms:Znt7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1307873. Slc30a7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737CytoplasmicSequence analysisAdd
BLAST
Transmembranei38 – 5821HelicalSequence analysisAdd
BLAST
Topological domaini59 – 679ExtracellularSequence analysis
Transmembranei68 – 8821HelicalSequence analysisAdd
BLAST
Topological domaini89 – 10214CytoplasmicSequence analysisAdd
BLAST
Transmembranei103 – 12321HelicalSequence analysisAdd
BLAST
Topological domaini124 – 14017ExtracellularSequence analysisAdd
BLAST
Transmembranei141 – 16121HelicalSequence analysisAdd
BLAST
Topological domaini162 – 23877CytoplasmicSequence analysisAdd
BLAST
Transmembranei239 – 25921HelicalSequence analysisAdd
BLAST
Topological domaini260 – 2645ExtracellularSequence analysis
Transmembranei265 – 28521HelicalSequence analysisAdd
BLAST
Topological domaini286 – 37893CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasmic, membrane-bounded vesicle Source: Ensembl
  • extracellular exosome Source: Ensembl
  • Golgi apparatus Source: BHF-UCL
  • integral component of membrane Source: UniProtKB-KW
  • perinuclear region of cytoplasm Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 378378Zinc transporter 7PRO_0000314301Add
BLAST

Proteomic databases

PaxDbiQ5BJM8.
PRIDEiQ5BJM8.

Expressioni

Gene expression databases

GenevisibleiQ5BJM8. RN.

Interactioni

Subunit structurei

Homooligomer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019172.

Structurei

3D structure databases

ProteinModelPortaliQ5BJM8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni161 – 22060His-rich loopAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1484. Eukaryota.
COG1230. LUCA.
GeneTreeiENSGT00630000089781.
HOGENOMiHOG000018690.
HOVERGENiHBG056637.
InParanoidiQ5BJM8.
KOiK14692.
OMAiHDDHSLE.
OrthoDBiEOG7C2R1S.
PhylomeDBiQ5BJM8.
TreeFamiTF315217.

Family and domain databases

Gene3Di1.20.1510.10. 2 hits.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 2 hits.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5BJM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPLSIKDDE YKPPKFNLFG KISGWFRSIL SDKTSRNLFF FLCLNLSFAF
60 70 80 90 100
VELLYGIWSN CLGLISDSFH MFFDSTAILA GLAASVISKW RDNDAFSYGY
110 120 130 140 150
VRAEVLAGFV NGLFLIFTAF FIFSEGVERA LAPPDVHHER LLLVSILGFV
160 170 180 190 200
VNLVGIFVFN HGGHGHSHGS GHGHSHSLFN GALDHSHGHE DHCHSHGAKH
210 220 230 240 250
GGAHSHDHDH AHGHGHLHSH DGPSFKETAG PSRQILQGVF LHILADTLGS
260 270 280 290 300
IGVIASAIMM QNFGLMIADP ICSILIAILI VVSVIPLLRE SIGILMQRTP
310 320 330 340 350
PSLENVLPQC YQRVQQLQGV YNLQEQHFWT LCSDVYVGTL KLVVAPDADA
360 370
RWILSQTHNI FTQAGVRQLY VQIDFAAM
Length:378
Mass (Da):41,774
Last modified:January 15, 2008 - v2
Checksum:iA82E9F3D02E2AF1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BP503381 mRNA. No translation available.
BC091417 mRNA. Translation: AAH91417.1.
BC107441 mRNA. Translation: AAI07442.1.
RefSeqiNP_001178644.1. NM_001191715.1.
UniGeneiRn.105204.

Genome annotation databases

EnsembliENSRNOT00000019172; ENSRNOP00000019172; ENSRNOG00000013912.
GeneIDi310801.
KEGGirno:310801.
UCSCiRGD:1307873. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BP503381 mRNA. No translation available.
BC091417 mRNA. Translation: AAH91417.1.
BC107441 mRNA. Translation: AAI07442.1.
RefSeqiNP_001178644.1. NM_001191715.1.
UniGeneiRn.105204.

3D structure databases

ProteinModelPortaliQ5BJM8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019172.

Proteomic databases

PaxDbiQ5BJM8.
PRIDEiQ5BJM8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019172; ENSRNOP00000019172; ENSRNOG00000013912.
GeneIDi310801.
KEGGirno:310801.
UCSCiRGD:1307873. rat.

Organism-specific databases

CTDi148867.
RGDi1307873. Slc30a7.

Phylogenomic databases

eggNOGiKOG1484. Eukaryota.
COG1230. LUCA.
GeneTreeiENSGT00630000089781.
HOGENOMiHOG000018690.
HOVERGENiHBG056637.
InParanoidiQ5BJM8.
KOiK14692.
OMAiHDDHSLE.
OrthoDBiEOG7C2R1S.
PhylomeDBiQ5BJM8.
TreeFamiTF315217.

Miscellaneous databases

NextBioi662653.
PROiQ5BJM8.

Gene expression databases

GenevisibleiQ5BJM8. RN.

Family and domain databases

Gene3Di1.20.1510.10. 2 hits.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 2 hits.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Expression profile of mRNAs from rat insulinoma cell line (RIN)."
    Takeda J., Wang H., Horikawa Y.
    Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-190.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 165-378.
    Tissue: Ovary and Spleen.

Entry informationi

Entry nameiZNT7_RAT
AccessioniPrimary (citable) accession number: Q5BJM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: May 11, 2016
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.