Q5BJH7 (YIF1B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein YIF1B

Alternative name(s):
YIP1-interacting factor homolog B

Gene names

Name:	YIF1B
ORF Names:	PP4519, UNQ3073/PRO9905

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the YIF1 family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5BJH7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5BJH7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.

Isoform 3 (identifier: Q5BJH7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     17-19: Missing.

Isoform 4 (identifier: Q5BJH7-4)

The sequence of this isoform differs from the canonical sequence as follows:
     17-19: Missing.
     264-294: IRTLRLKILADAAAEGVPVRGARNQLRMYLT → FPLLPGAVAHACNPSTLGGRGGRITRSGRCG
     295-314: Missing.

Isoform 5 (identifier: Q5BJH7-5)

The sequence of this isoform differs from the canonical sequence as follows:
     17-19: Missing.
     264-297: IRTLRLKILADAAAEGVPVRGARNQLRMYLTMAV → FPLLPGAVAHACNPSTLGGRGGRITRSGDQDHPG
     298-314: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 314	314	Protein YIF1B		PRO_0000307258
Regions
	Topological domain	1 – 156	156	Cytoplasmic Potential
	Transmembrane	157 – 177	21	Helical; Potential
	Topological domain	178 – 192	15	Extracellular Potential
	Transmembrane	193 – 213	21	Helical; Potential
	Topological domain	214 – 219	6	Cytoplasmic Potential
	Transmembrane	220 – 240	21	Helical; Potential
	Topological domain	241	1	Extracellular Potential
	Transmembrane	242 – 262	21	Helical; Potential
	Topological domain	263 – 292	30	Cytoplasmic Potential
	Transmembrane	293 – 313	21	Helical; Potential
	Topological domain	314	1	Extracellular Potential
Amino acid modifications
	Modified residue	65	1	Phosphoserine Ref.6 Ref.7
Natural variations
	Alternative sequence	1 – 31	31	Missing in isoform 2.		VSP_028650
	Alternative sequence	17 – 19	3	Missing in isoform 3, isoform 4 and isoform 5.		VSP_028651
	Alternative sequence	264 – 297	34	IRTLR…LTMAV → FPLLPGAVAHACNPSTLGGR GGRITRSGDQDHPG in isoform 5.		VSP_028652
	Alternative sequence	264 – 294	31	IRTLR…RMYLT → FPLLPGAVAHACNPSTLGGR GGRITRSGRCG in isoform 4.		VSP_028653
	Alternative sequence	295 – 314	20	Missing in isoform 4.		VSP_028654
	Alternative sequence	298 – 314	17	Missing in isoform 5.		VSP_028655
	Natural variant	56	1	P → S. Corresponds to variant rs11556992 [ dbSNP | Ensembl ].		VAR_035385

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 27, 2005. Version 1. Checksum: 93A2521A3332D3AD	FASTA	314	34,435
	10 20 30 40 50 60 MHPAGLAAAA AGTPRLRKWP SKRRIPVSQP GMADPHQLFD DTSSAQSRGY GAQRAPGGLS 70 80 90 100 110 120 YPAASPTPHA AFLADPVSNM AMAYGSSLAA QGKELVDKNI DRFIPITKLK YYFAVDTMYV 130 140 150 160 170 180 GRKLGLLFFP YLHQDWEVQY QQDTPVAPRF DVNAPDLYIP AMAFITYVLV AGLALGTQDR 190 200 210 220 230 240 FSPDLLGLQA SSALAWLTLE VLAILLSLYL VTVNTDLTTI DLVAFLGYKY VGMIGGVLMG 250 260 270 280 290 300 LLFGKIGYYL VLGWCCVAIF VFMIRTLRLK ILADAAAEGV PVRGARNQLR MYLTMAVAAA 310 QPMLMYWLTF HLVR
	Isoform 2 [UniParc]. Checksum: F68245FE42608C59	FASTA	283	31,175
	10 20 30 40 50 60 MADPHQLFDD TSSAQSRGYG AQRAPGGLSY PAASPTPHAA FLADPVSNMA MAYGSSLAAQ 70 80 90 100 110 120 GKELVDKNID RFIPITKLKY YFAVDTMYVG RKLGLLFFPY LHQDWEVQYQ QDTPVAPRFD 130 140 150 160 170 180 VNAPDLYIPA MAFITYVLVA GLALGTQDRF SPDLLGLQAS SALAWLTLEV LAILLSLYLV 190 200 210 220 230 240 TVNTDLTTID LVAFLGYKYV GMIGGVLMGL LFGKIGYYLV LGWCCVAIFV FMIRTLRLKI 250 260 270 280 LADAAAEGVP VRGARNQLRM YLTMAVAAAQ PMLMYWLTFH LVR
	Isoform 3 [UniParc]. Checksum: 006B7C3F190E281E	FASTA	311	33,965
	10 20 30 40 50 60 MHPAGLAAAA AGTPRLPSKR RIPVSQPGMA DPHQLFDDTS SAQSRGYGAQ RAPGGLSYPA 70 80 90 100 110 120 ASPTPHAAFL ADPVSNMAMA YGSSLAAQGK ELVDKNIDRF IPITKLKYYF AVDTMYVGRK 130 140 150 160 170 180 LGLLFFPYLH QDWEVQYQQD TPVAPRFDVN APDLYIPAMA FITYVLVAGL ALGTQDRFSP 190 200 210 220 230 240 DLLGLQASSA LAWLTLEVLA ILLSLYLVTV NTDLTTIDLV AFLGYKYVGM IGGVLMGLLF 250 260 270 280 290 300 GKIGYYLVLG WCCVAIFVFM IRTLRLKILA DAAAEGVPVR GARNQLRMYL TMAVAAAQPM 310 LMYWLTFHLV R
	Isoform 4 [UniParc]. Checksum: 76319390816EF13F	FASTA	291	31,245
	10 20 30 40 50 60 MHPAGLAAAA AGTPRLPSKR RIPVSQPGMA DPHQLFDDTS SAQSRGYGAQ RAPGGLSYPA 70 80 90 100 110 120 ASPTPHAAFL ADPVSNMAMA YGSSLAAQGK ELVDKNIDRF IPITKLKYYF AVDTMYVGRK 130 140 150 160 170 180 LGLLFFPYLH QDWEVQYQQD TPVAPRFDVN APDLYIPAMA FITYVLVAGL ALGTQDRFSP 190 200 210 220 230 240 DLLGLQASSA LAWLTLEVLA ILLSLYLVTV NTDLTTIDLV AFLGYKYVGM IGGVLMGLLF 250 260 270 280 290 GKIGYYLVLG WCCVAIFVFM FPLLPGAVAH ACNPSTLGGR GGRITRSGRC G
	Isoform 5 [UniParc]. Checksum: 3ADFF564F9ED3081	FASTA	294	31,579
	10 20 30 40 50 60 MHPAGLAAAA AGTPRLPSKR RIPVSQPGMA DPHQLFDDTS SAQSRGYGAQ RAPGGLSYPA 70 80 90 100 110 120 ASPTPHAAFL ADPVSNMAMA YGSSLAAQGK ELVDKNIDRF IPITKLKYYF AVDTMYVGRK 130 140 150 160 170 180 LGLLFFPYLH QDWEVQYQQD TPVAPRFDVN APDLYIPAMA FITYVLVAGL ALGTQDRFSP 190 200 210 220 230 240 DLLGLQASSA LAWLTLEVLA ILLSLYLVTV NTDLTTIDLV AFLGYKYVGM IGGVLMGLLF 250 260 270 280 290 GKIGYYLVLG WCCVAIFVFM FPLLPGAVAH ACNPSTLGGR GGRITRSGDQ DHPG

References

[1]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[2]	"Large-scale cDNA transfection screening for genes related to cancer development and progression." Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J. Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Lymph node.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-314 (ISOFORM 3). Tissue: Colon, Lung and Placenta.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-65, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-65, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[8]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY358965 mRNA. Translation: AAQ89324.1. AF258578 mRNA. Translation: AAG23781.1. AL833382 mRNA. Translation: CAI46138.1. CH471126 Genomic DNA. Translation: EAW56772.1. BC007644 mRNA. Translation: AAH07644.1. BC014974 mRNA. Translation: AAH14974.1. BC091477 mRNA. Translation: AAH91477.2.
IPI	IPI00060144. IPI00063544. IPI00395508. IPI00736813. IPI00869035.
RefSeq	NP_001034760.1. NM_001039671.2. NP_001034761.1. NM_001039672.2. NP_001034762.1. NM_001039673.2. NP_001138933.1. NM_001145461.1. NP_001138934.1. NM_001145462.1. NP_001138935.1. NM_001145463.1. NP_291035.1. NM_033557.3.
UniGene	Hs.280741.
3D structure databases
ProteinModelPortal	Q5BJH7.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000343435.
PTM databases
PhosphoSite	Q5BJH7.
Polymorphism databases
DMDM	121944384.
Proteomic databases
PaxDb	Q5BJH7.
PRIDE	Q5BJH7.
Protocols and materials databases
DNASU	90522.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000337679; ENSP00000337411; ENSG00000167645. ENST00000339413; ENSP00000343435; ENSG00000167645. ENST00000392124; ENSP00000375971; ENSG00000167645. ENST00000591755; ENSP00000465446; ENSG00000167645. ENST00000591784; ENSP00000465230; ENSG00000167645. ENST00000592694; ENSP00000466428; ENSG00000167645.
GeneID	90522.
KEGG	hsa:90522.
UCSC	uc002ohw.2. human. uc002ohy.2. human. uc002oia.2. human. uc002oib.3. human.
Organism-specific databases
CTD	90522.
GeneCards	GC19M038794.
HGNC	HGNC:30511. YIF1B.
HPA	HPA055257.
neXtProt	NX_Q5BJH7.
PharmGKB	PA142670561.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5197.
HOGENOM	HOG000234333.
HOVERGEN	HBG053252.
InParanoid	Q5BJH7.
OMA	PMSNLAM.
OrthoDB	EOG40S0G5.
Gene expression databases
ArrayExpress	Q5BJH7.
Bgee	Q5BJH7.
CleanEx	HS_YIF1B.
Genevestigator	Q5BJH7.
Family and domain databases
InterPro	IPR005578. Hrf1. [Graphical view]
PANTHER	PTHR14083. PTHR14083. 1 hit.
Pfam	PF03878. YIF1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	90522.
NextBio	76803.

Entry information

Entry name

YIF1B_HUMAN

Accession

Primary (citable) accession number: Q5BJH7
Secondary accession number(s): Q5JPC2 , Q8WY70, Q96C02, Q96IC4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	September 27, 2005
Last modified:	May 1, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.