ID TM128_HUMAN Reviewed; 165 AA. AC Q5BJH2; B4DHS7; D3DVS1; D3DVS3; Q5H9U6; Q96I94; DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot. DT 28-MAR-2018, sequence version 2. DT 24-JAN-2024, entry version 119. DE RecName: Full=Transmembrane protein 128; GN Name=TMEM128; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ILE-16. RC TISSUE=Caudate nucleus; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Amygdala; RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., RA Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., RA Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 and RT 4."; RL Nature 434:724-731(2005). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT RP ILE-16. RC TISSUE=Placenta, and Uterus; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- INTERACTION: CC Q5BJH2; Q9BXK5: BCL2L13; NbExp=3; IntAct=EBI-10243515, EBI-747430; CC Q5BJH2-2; Q13520: AQP6; NbExp=3; IntAct=EBI-10694905, EBI-13059134; CC Q5BJH2-2; Q3SXY8: ARL13B; NbExp=3; IntAct=EBI-10694905, EBI-11343438; CC Q5BJH2-2; Q8NFU1: BEST2; NbExp=3; IntAct=EBI-10694905, EBI-19947314; CC Q5BJH2-2; P25942: CD40; NbExp=3; IntAct=EBI-10694905, EBI-525714; CC Q5BJH2-2; P19397: CD53; NbExp=3; IntAct=EBI-10694905, EBI-6657396; CC Q5BJH2-2; P11912: CD79A; NbExp=3; IntAct=EBI-10694905, EBI-7797864; CC Q5BJH2-2; O00501: CLDN5; NbExp=3; IntAct=EBI-10694905, EBI-18400628; CC Q5BJH2-2; O95471: CLDN7; NbExp=3; IntAct=EBI-10694905, EBI-740744; CC Q5BJH2-2; P49447: CYB561; NbExp=3; IntAct=EBI-10694905, EBI-8646596; CC Q5BJH2-2; Q9BQA9: CYBC1; NbExp=3; IntAct=EBI-10694905, EBI-2680384; CC Q5BJH2-2; Q9GZR5: ELOVL4; NbExp=3; IntAct=EBI-10694905, EBI-18535450; CC Q5BJH2-2; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-10694905, EBI-781551; CC Q5BJH2-2; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-10694905, EBI-18304435; CC Q5BJH2-2; Q05329: GAD2; NbExp=3; IntAct=EBI-10694905, EBI-9304251; CC Q5BJH2-2; P17302: GJA1; NbExp=3; IntAct=EBI-10694905, EBI-1103439; CC Q5BJH2-2; P48165: GJA8; NbExp=3; IntAct=EBI-10694905, EBI-17458373; CC Q5BJH2-2; O95377: GJB5; NbExp=3; IntAct=EBI-10694905, EBI-3909454; CC Q5BJH2-2; Q5T7V8: GORAB; NbExp=3; IntAct=EBI-10694905, EBI-3917143; CC Q5BJH2-2; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-10694905, EBI-13345167; CC Q5BJH2-2; Q8TED1: GPX8; NbExp=3; IntAct=EBI-10694905, EBI-11721746; CC Q5BJH2-2; P62993: GRB2; NbExp=3; IntAct=EBI-10694905, EBI-401755; CC Q5BJH2-2; Q8NBQ5: HSD17B11; NbExp=3; IntAct=EBI-10694905, EBI-1052304; CC Q5BJH2-2; Q9Y5U9: IER3IP1; NbExp=3; IntAct=EBI-10694905, EBI-725665; CC Q5BJH2-2; P26951: IL3RA; NbExp=3; IntAct=EBI-10694905, EBI-1757512; CC Q5BJH2-2; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-10694905, EBI-10266796; CC Q5BJH2-2; O95279: KCNK5; NbExp=3; IntAct=EBI-10694905, EBI-3934936; CC Q5BJH2-2; A8MZ59: LEUTX; NbExp=3; IntAct=EBI-10694905, EBI-17490413; CC Q5BJH2-2; Q6ZUX7: LHFPL2; NbExp=3; IntAct=EBI-10694905, EBI-17566767; CC Q5BJH2-2; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-10694905, EBI-2820517; CC Q5BJH2-2; Q9GZY8-5: MFF; NbExp=3; IntAct=EBI-10694905, EBI-11956541; CC Q5BJH2-2; Q6N075: MFSD5; NbExp=3; IntAct=EBI-10694905, EBI-3920969; CC Q5BJH2-2; Q9Y676: MRPS18B; NbExp=3; IntAct=EBI-10694905, EBI-750085; CC Q5BJH2-2; Q99551: MTERF1; NbExp=3; IntAct=EBI-10694905, EBI-2690033; CC Q5BJH2-2; Q9H2K0: MTIF3; NbExp=3; IntAct=EBI-10694905, EBI-3923617; CC Q5BJH2-2; P15941-11: MUC1; NbExp=3; IntAct=EBI-10694905, EBI-17263240; CC Q5BJH2-2; Q9H6H4: REEP4; NbExp=3; IntAct=EBI-10694905, EBI-7545592; CC Q5BJH2-2; Q86VR2: RETREG3; NbExp=3; IntAct=EBI-10694905, EBI-10192441; CC Q5BJH2-2; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-10694905, EBI-17247926; CC Q5BJH2-2; Q9BY50: SEC11C; NbExp=3; IntAct=EBI-10694905, EBI-2855401; CC Q5BJH2-2; Q3SXP7: SHISAL1; NbExp=3; IntAct=EBI-10694905, EBI-18037857; CC Q5BJH2-2; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-10694905, EBI-18159983; CC Q5BJH2-2; P54219-3: SLC18A1; NbExp=3; IntAct=EBI-10694905, EBI-17595455; CC Q5BJH2-2; P43003: SLC1A3; NbExp=3; IntAct=EBI-10694905, EBI-359038; CC Q5BJH2-2; Q9BXS9-3: SLC26A6; NbExp=3; IntAct=EBI-10694905, EBI-12814225; CC Q5BJH2-2; O95436-2: SLC34A2; NbExp=3; IntAct=EBI-10694905, EBI-12811757; CC Q5BJH2-2; Q8TBB6: SLC7A14; NbExp=3; IntAct=EBI-10694905, EBI-5235586; CC Q5BJH2-2; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-10694905, EBI-17280858; CC Q5BJH2-2; Q16623: STX1A; NbExp=3; IntAct=EBI-10694905, EBI-712466; CC Q5BJH2-2; Q96A25: TMEM106A; NbExp=3; IntAct=EBI-10694905, EBI-3915978; CC Q5BJH2-2; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-10694905, EBI-10982110; CC Q5BJH2-2; Q96B21: TMEM45B; NbExp=3; IntAct=EBI-10694905, EBI-3923061; CC Q5BJH2-2; Q4KMG9: TMEM52B; NbExp=3; IntAct=EBI-10694905, EBI-18178701; CC Q5BJH2-2; Q96HE8: TMEM80; NbExp=3; IntAct=EBI-10694905, EBI-11742770; CC Q5BJH2-2; O15393-2: TMPRSS2; NbExp=3; IntAct=EBI-10694905, EBI-12345267; CC Q5BJH2-2; Q9Y320: TMX2; NbExp=3; IntAct=EBI-10694905, EBI-6447886; CC Q5BJH2-2; Q96MV8: ZDHHC15; NbExp=3; IntAct=EBI-10694905, EBI-12837904; CC Q5BJH2-2; Q5T4F4: ZFYVE27; NbExp=3; IntAct=EBI-10694905, EBI-3892947; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane CC protein {ECO:0000305}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q5BJH2-1; Sequence=Displayed; CC Name=2; CC IsoId=Q5BJH2-2; Sequence=VSP_021229; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK295248; BAG58239.1; -; mRNA. DR EMBL; CR933611; CAI45928.1; -; mRNA. DR EMBL; AC011744; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471131; EAW82440.1; -; Genomic_DNA. DR EMBL; CH471131; EAW82441.1; -; Genomic_DNA. DR EMBL; CH471131; EAW82442.1; -; Genomic_DNA. DR EMBL; CH471131; EAW82443.1; -; Genomic_DNA. DR EMBL; CH471131; EAW82444.1; -; Genomic_DNA. DR EMBL; BC007729; AAH07729.1; -; mRNA. DR EMBL; BC091482; AAH91482.1; -; mRNA. DR CCDS; CCDS3373.1; -. [Q5BJH2-2] DR CCDS; CCDS75099.1; -. [Q5BJH2-1] DR RefSeq; NP_001284480.1; NM_001297551.1. [Q5BJH2-1] DR RefSeq; NP_001284481.1; NM_001297552.1. [Q5BJH2-1] DR RefSeq; NP_116316.1; NM_032927.3. [Q5BJH2-2] DR RefSeq; XP_005248091.1; XM_005248034.2. [Q5BJH2-1] DR AlphaFoldDB; Q5BJH2; -. DR BioGRID; 124428; 88. DR IntAct; Q5BJH2; 59. DR STRING; 9606.ENSP00000372201; -. DR TCDB; 9.B.202.1.1; the 4 tms tmem128 (tmem128) family. DR SwissPalm; Q5BJH2; -. DR BioMuta; TMEM128; -. DR DMDM; 74736022; -. DR EPD; Q5BJH2; -. DR jPOST; Q5BJH2; -. DR MassIVE; Q5BJH2; -. DR MaxQB; Q5BJH2; -. DR PaxDb; 9606-ENSP00000372201; -. DR PeptideAtlas; Q5BJH2; -. DR ProteomicsDB; 12769; -. DR ProteomicsDB; 62691; -. [Q5BJH2-1] DR Pumba; Q5BJH2; -. DR Antibodypedia; 51629; 10 antibodies from 7 providers. DR DNASU; 85013; -. DR Ensembl; ENST00000254742.6; ENSP00000254742.2; ENSG00000132406.12. [Q5BJH2-2] DR Ensembl; ENST00000382753.5; ENSP00000372201.4; ENSG00000132406.12. [Q5BJH2-1] DR GeneID; 85013; -. DR KEGG; hsa:85013; -. DR MANE-Select; ENST00000382753.5; ENSP00000372201.4; NM_001297551.2; NP_001284480.1. DR UCSC; uc003ghq.2; human. [Q5BJH2-1] DR UCSC; uc003ghr.2; human. DR AGR; HGNC:28201; -. DR CTD; 85013; -. DR DisGeNET; 85013; -. DR GeneCards; TMEM128; -. DR HGNC; HGNC:28201; TMEM128. DR HPA; ENSG00000132406; Low tissue specificity. DR neXtProt; NX_Q5BJH2; -. DR OpenTargets; ENSG00000132406; -. DR PharmGKB; PA143485648; -. DR VEuPathDB; HostDB:ENSG00000132406; -. DR eggNOG; ENOG502RZ1U; Eukaryota. DR GeneTree; ENSGT00390000012901; -. DR HOGENOM; CLU_117906_1_0_1; -. DR InParanoid; Q5BJH2; -. DR OMA; YLEWYHG; -. DR OrthoDB; 2940270at2759; -. DR PhylomeDB; Q5BJH2; -. DR TreeFam; TF328406; -. DR PathwayCommons; Q5BJH2; -. DR SignaLink; Q5BJH2; -. DR BioGRID-ORCS; 85013; 7 hits in 1127 CRISPR screens. DR ChiTaRS; TMEM128; human. DR GenomeRNAi; 85013; -. DR Pharos; Q5BJH2; Tdark. DR PRO; PR:Q5BJH2; -. DR Proteomes; UP000005640; Chromosome 4. DR RNAct; Q5BJH2; Protein. DR Bgee; ENSG00000132406; Expressed in oocyte and 190 other cell types or tissues. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR InterPro; IPR033579; TMEM128. DR PANTHER; PTHR31134; TRANSMEMBRANE PROTEIN 128; 1. DR PANTHER; PTHR31134:SF1; TRANSMEMBRANE PROTEIN 128; 1. DR Pfam; PF20479; TMEM128; 1. DR Genevisible; Q5BJH2; HS. PE 1: Evidence at protein level; KW Alternative splicing; Membrane; Reference proteome; Transmembrane; KW Transmembrane helix. FT CHAIN 1..165 FT /note="Transmembrane protein 128" FT /id="PRO_0000254556" FT TRANSMEM 49..69 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 81..101 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 119..139 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 144..164 FT /note="Helical" FT /evidence="ECO:0000255" FT VAR_SEQ 1..32 FT /note="MDSSRARQQLRRRFLLLPDAEAQLDREGDAGP -> MPPFGYKT (in FT isoform 2)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_021229" FT VARIANT 16 FT /note="L -> I (in dbSNP:rs6854167)" FT /evidence="ECO:0000269|PubMed:14702039, FT ECO:0000269|PubMed:15489334" FT /id="VAR_080190" FT CONFLICT 43 FT /note="K -> E (in Ref. 2; CAI45928)" FT /evidence="ECO:0000305" SQ SEQUENCE 165 AA; 18822 MW; C1A4890B243C7AEF CRC64; MDSSRARQQL RRRFLLLPDA EAQLDREGDA GPETSTAVEK KEKPLPRLNI HSGFWILASI VVTYYVDFFK TLKENFHTSS WFLCGSALLL VSLSIAFYCI VYLEWYCGIG EYDVKYPALI PITTASFIAA GICFNIALWH VWSFFTPLLL FTQFMGVVMF ITLLG //