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Q5BJH2

- TM128_HUMAN

UniProt

Q5BJH2 - TM128_HUMAN

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Protein
Transmembrane protein 128
Gene
TMEM128
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 128
Gene namesi
Name:TMEM128
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:28201. TMEM128.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei49 – 6921Helical; Reviewed prediction
Add
BLAST
Transmembranei81 – 10121Helical; Reviewed prediction
Add
BLAST
Transmembranei119 – 13921Helical; Reviewed prediction
Add
BLAST
Transmembranei144 – 16421Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485648.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 165165Transmembrane protein 128
PRO_0000254556Add
BLAST

Proteomic databases

MaxQBiQ5BJH2.
PRIDEiQ5BJH2.

Expressioni

Gene expression databases

ArrayExpressiQ5BJH2.
BgeeiQ5BJH2.
CleanExiHS_TMEM128.
GenevestigatoriQ5BJH2.

Organism-specific databases

HPAiHPA044809.

Interactioni

Protein-protein interaction databases

BioGridi124428. 1 interaction.
STRINGi9606.ENSP00000254742.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43435.
HOGENOMiHOG000060333.
HOVERGENiHBG059771.
InParanoidiQ5BJH2.
OrthoDBiEOG783MZ1.
PhylomeDBiQ5BJH2.
TreeFamiTF328406.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5BJH2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDSSRARQQL RRRFLILPDA EAQLDREGDA GPETSTAVEK KEKPLPRLNI    50
HSGFWILASI VVTYYVDFFK TLKENFHTSS WFLCGSALLL VSLSIAFYCI 100
VYLEWYCGIG EYDVKYPALI PITTASFIAA GICFNIALWH VWSFFTPLLL 150
FTQFMGVVMF ITLLG 165
Length:165
Mass (Da):18,822
Last modified:April 12, 2005 - v1
Checksum:i31F1890E746A9C0C
GO
Isoform 2 (identifier: Q5BJH2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: MDSSRARQQLRRRFLILPDAEAQLDREGDAGP → MPPFGYKT

Note: No experimental confirmation available.

Show »
Length:141
Mass (Da):16,093
Checksum:iDFC33A6E528E3DC4
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3232MDSSR…GDAGP → MPPFGYKT in isoform 2.
VSP_021229Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161I → L in CAI45928. 1 Publication
Sequence conflicti43 – 431K → E in CAI45928. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK295248 mRNA. Translation: BAG58239.1.
CR933611 mRNA. Translation: CAI45928.1.
CH471131 Genomic DNA. Translation: EAW82440.1.
CH471131 Genomic DNA. Translation: EAW82444.1.
BC007729 mRNA. Translation: AAH07729.1.
BC091482 mRNA. Translation: AAH91482.1.
CCDSiCCDS3373.1. [Q5BJH2-2]
RefSeqiNP_116316.1. NM_032927.2. [Q5BJH2-2]
UniGeneiHs.12845.

Genome annotation databases

EnsembliENST00000254742; ENSP00000254742; ENSG00000132406. [Q5BJH2-2]
GeneIDi85013.
KEGGihsa:85013.
UCSCiuc003ghq.1. human. [Q5BJH2-2]

Polymorphism databases

DMDMi74736022.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK295248 mRNA. Translation: BAG58239.1 .
CR933611 mRNA. Translation: CAI45928.1 .
CH471131 Genomic DNA. Translation: EAW82440.1 .
CH471131 Genomic DNA. Translation: EAW82444.1 .
BC007729 mRNA. Translation: AAH07729.1 .
BC091482 mRNA. Translation: AAH91482.1 .
CCDSi CCDS3373.1. [Q5BJH2-2 ]
RefSeqi NP_116316.1. NM_032927.2. [Q5BJH2-2 ]
UniGenei Hs.12845.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124428. 1 interaction.
STRINGi 9606.ENSP00000254742.

Polymorphism databases

DMDMi 74736022.

Proteomic databases

MaxQBi Q5BJH2.
PRIDEi Q5BJH2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000254742 ; ENSP00000254742 ; ENSG00000132406 . [Q5BJH2-2 ]
GeneIDi 85013.
KEGGi hsa:85013.
UCSCi uc003ghq.1. human. [Q5BJH2-2 ]

Organism-specific databases

CTDi 85013.
GeneCardsi GC04M004237.
H-InvDB HIX0200624.
HGNCi HGNC:28201. TMEM128.
HPAi HPA044809.
neXtProti NX_Q5BJH2.
PharmGKBi PA143485648.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43435.
HOGENOMi HOG000060333.
HOVERGENi HBG059771.
InParanoidi Q5BJH2.
OrthoDBi EOG783MZ1.
PhylomeDBi Q5BJH2.
TreeFami TF328406.

Miscellaneous databases

GenomeRNAii 85013.
NextBioi 75623.
PROi Q5BJH2.

Gene expression databases

ArrayExpressi Q5BJH2.
Bgeei Q5BJH2.
CleanExi HS_TMEM128.
Genevestigatori Q5BJH2.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Caudate nucleus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Amygdala.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Placenta and Uterus.

Entry informationi

Entry nameiTM128_HUMAN
AccessioniPrimary (citable) accession number: Q5BJH2
Secondary accession number(s): B4DHS7
, D3DVS3, Q5H9U6, Q96I94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: April 12, 2005
Last modified: July 9, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM

External Data

Dasty 3

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