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Q5BJH2 (TM128_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protein 128
Gene names
Name:TMEM128
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length165 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5BJH2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5BJH2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: MDSSRARQQLRRRFLILPDAEAQLDREGDAGP → MPPFGYKT
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 165165Transmembrane protein 128
PRO_0000254556

Regions

Transmembrane49 – 6921Helical; Potential
Transmembrane81 – 10121Helical; Potential
Transmembrane119 – 13921Helical; Potential
Transmembrane144 – 16421Helical; Potential

Natural variations

Alternative sequence1 – 3232MDSSR…GDAGP → MPPFGYKT in isoform 2.
VSP_021229

Experimental info

Sequence conflict161I → L in CAI45928. Ref.2
Sequence conflict431K → E in CAI45928. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 12, 2005. Version 1.
Checksum: 31F1890E746A9C0C

FASTA16518,822
        10         20         30         40         50         60 
MDSSRARQQL RRRFLILPDA EAQLDREGDA GPETSTAVEK KEKPLPRLNI HSGFWILASI 

        70         80         90        100        110        120 
VVTYYVDFFK TLKENFHTSS WFLCGSALLL VSLSIAFYCI VYLEWYCGIG EYDVKYPALI 

       130        140        150        160 
PITTASFIAA GICFNIALWH VWSFFTPLLL FTQFMGVVMF ITLLG 

« Hide

Isoform 2 [UniParc].

Checksum: DFC33A6E528E3DC4
Show »

FASTA14116,093

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Caudate nucleus.
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Amygdala.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Placenta and Uterus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK295248 mRNA. Translation: BAG58239.1.
CR933611 mRNA. Translation: CAI45928.1.
CH471131 Genomic DNA. Translation: EAW82440.1.
CH471131 Genomic DNA. Translation: EAW82444.1.
BC007729 mRNA. Translation: AAH07729.1.
BC091482 mRNA. Translation: AAH91482.1.
CCDSCCDS3373.1. [Q5BJH2-2]
RefSeqNP_116316.1. NM_032927.2. [Q5BJH2-2]
UniGeneHs.12845.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124428. 1 interaction.
STRING9606.ENSP00000254742.

Polymorphism databases

DMDM74736022.

Proteomic databases

MaxQBQ5BJH2.
PRIDEQ5BJH2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000254742; ENSP00000254742; ENSG00000132406. [Q5BJH2-2]
GeneID85013.
KEGGhsa:85013.
UCSCuc003ghq.1. human. [Q5BJH2-2]

Organism-specific databases

CTD85013.
GeneCardsGC04M004237.
H-InvDBHIX0200624.
HGNCHGNC:28201. TMEM128.
HPAHPA044809.
neXtProtNX_Q5BJH2.
PharmGKBPA143485648.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG43435.
HOGENOMHOG000060333.
HOVERGENHBG059771.
InParanoidQ5BJH2.
OrthoDBEOG783MZ1.
PhylomeDBQ5BJH2.
TreeFamTF328406.

Gene expression databases

ArrayExpressQ5BJH2.
BgeeQ5BJH2.
CleanExHS_TMEM128.
GenevestigatorQ5BJH2.

Family and domain databases

ProtoNetSearch...

Other

GenomeRNAi85013.
NextBio75623.
PROQ5BJH2.

Entry information

Entry nameTM128_HUMAN
AccessionPrimary (citable) accession number: Q5BJH2
Secondary accession number(s): B4DHS7 expand/collapse secondary AC list , D3DVS3, Q5H9U6, Q96I94
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: April 12, 2005
Last modified: July 9, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM