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Protein

Transmembrane protein 128

Gene

TMEM128

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 128
Gene namesi
Name:TMEM128
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:28201. TMEM128.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei49 – 6921HelicalSequence AnalysisAdd
BLAST
Transmembranei81 – 10121HelicalSequence AnalysisAdd
BLAST
Transmembranei119 – 13921HelicalSequence AnalysisAdd
BLAST
Transmembranei144 – 16421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485648.

Polymorphism and mutation databases

DMDMi74736022.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 165165Transmembrane protein 128PRO_0000254556Add
BLAST

Proteomic databases

MaxQBiQ5BJH2.
PRIDEiQ5BJH2.

Expressioni

Gene expression databases

BgeeiQ5BJH2.
CleanExiHS_TMEM128.
ExpressionAtlasiQ5BJH2. baseline and differential.
GenevestigatoriQ5BJH2.

Organism-specific databases

HPAiHPA044809.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BCL2L13Q9BXK53EBI-10243515,EBI-747430

Protein-protein interaction databases

BioGridi124428. 3 interactions.
IntActiQ5BJH2. 1 interaction.
STRINGi9606.ENSP00000254742.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43435.
GeneTreeiENSGT00390000012901.
HOGENOMiHOG000060333.
HOVERGENiHBG059771.
InParanoidiQ5BJH2.
OrthoDBiEOG783MZ1.
PhylomeDBiQ5BJH2.
TreeFamiTF328406.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5BJH2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSSRARQQL RRRFLILPDA EAQLDREGDA GPETSTAVEK KEKPLPRLNI
60 70 80 90 100
HSGFWILASI VVTYYVDFFK TLKENFHTSS WFLCGSALLL VSLSIAFYCI
110 120 130 140 150
VYLEWYCGIG EYDVKYPALI PITTASFIAA GICFNIALWH VWSFFTPLLL
160
FTQFMGVVMF ITLLG
Length:165
Mass (Da):18,822
Last modified:April 12, 2005 - v1
Checksum:i31F1890E746A9C0C
GO
Isoform 2 (identifier: Q5BJH2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: MDSSRARQQLRRRFLILPDAEAQLDREGDAGP → MPPFGYKT

Note: No experimental confirmation available.

Show »
Length:141
Mass (Da):16,093
Checksum:iDFC33A6E528E3DC4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161I → L in CAI45928 (PubMed:17974005).Curated
Sequence conflicti43 – 431K → E in CAI45928 (PubMed:17974005).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3232MDSSR…GDAGP → MPPFGYKT in isoform 2. 1 PublicationVSP_021229Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295248 mRNA. Translation: BAG58239.1.
CR933611 mRNA. Translation: CAI45928.1.
CH471131 Genomic DNA. Translation: EAW82440.1.
CH471131 Genomic DNA. Translation: EAW82444.1.
BC007729 mRNA. Translation: AAH07729.1.
BC091482 mRNA. Translation: AAH91482.1.
CCDSiCCDS3373.1. [Q5BJH2-2]
CCDS75099.1. [Q5BJH2-1]
RefSeqiNP_001284480.1. NM_001297551.1.
NP_001284481.1. NM_001297552.1.
NP_116316.1. NM_032927.3. [Q5BJH2-2]
UniGeneiHs.12845.

Genome annotation databases

EnsembliENST00000254742; ENSP00000254742; ENSG00000132406. [Q5BJH2-2]
GeneIDi85013.
KEGGihsa:85013.
UCSCiuc003ghq.1. human. [Q5BJH2-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295248 mRNA. Translation: BAG58239.1.
CR933611 mRNA. Translation: CAI45928.1.
CH471131 Genomic DNA. Translation: EAW82440.1.
CH471131 Genomic DNA. Translation: EAW82444.1.
BC007729 mRNA. Translation: AAH07729.1.
BC091482 mRNA. Translation: AAH91482.1.
CCDSiCCDS3373.1. [Q5BJH2-2]
CCDS75099.1. [Q5BJH2-1]
RefSeqiNP_001284480.1. NM_001297551.1.
NP_001284481.1. NM_001297552.1.
NP_116316.1. NM_032927.3. [Q5BJH2-2]
UniGeneiHs.12845.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124428. 3 interactions.
IntActiQ5BJH2. 1 interaction.
STRINGi9606.ENSP00000254742.

Polymorphism and mutation databases

DMDMi74736022.

Proteomic databases

MaxQBiQ5BJH2.
PRIDEiQ5BJH2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254742; ENSP00000254742; ENSG00000132406. [Q5BJH2-2]
GeneIDi85013.
KEGGihsa:85013.
UCSCiuc003ghq.1. human. [Q5BJH2-2]

Organism-specific databases

CTDi85013.
GeneCardsiGC04M004237.
H-InvDBHIX0200624.
HGNCiHGNC:28201. TMEM128.
HPAiHPA044809.
neXtProtiNX_Q5BJH2.
PharmGKBiPA143485648.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG43435.
GeneTreeiENSGT00390000012901.
HOGENOMiHOG000060333.
HOVERGENiHBG059771.
InParanoidiQ5BJH2.
OrthoDBiEOG783MZ1.
PhylomeDBiQ5BJH2.
TreeFamiTF328406.

Miscellaneous databases

GenomeRNAii85013.
NextBioi75623.
PROiQ5BJH2.

Gene expression databases

BgeeiQ5BJH2.
CleanExiHS_TMEM128.
ExpressionAtlasiQ5BJH2. baseline and differential.
GenevestigatoriQ5BJH2.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Caudate nucleus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Amygdala.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Placenta and Uterus.

Entry informationi

Entry nameiTM128_HUMAN
AccessioniPrimary (citable) accession number: Q5BJH2
Secondary accession number(s): B4DHS7
, D3DVS3, Q5H9U6, Q96I94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: April 12, 2005
Last modified: April 29, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.