Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine hydroxymethyltransferase

Gene

SHMT2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Interconversion of serine and glycine.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotation

Keywords - Biological processi

One-carbon metabolismUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine hydroxymethyltransferaseUniRule annotation (EC:2.1.2.1UniRule annotation)
Gene namesi
Name:SHMT2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35755.

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei256N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PaxDbiQ5BJF5.
PeptideAtlasiQ5BJF5.
PRIDEiQ5BJF5.

Expressioni

Gene expression databases

GenevisibleiQ5BJF5. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000333667.

Structurei

3D structure databases

ProteinModelPortaliQ5BJF5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SHMT family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2467. Eukaryota.
COG0112. LUCA.
HOVERGENiHBG002807.
KOiK00600.

Family and domain databases

CDDicd00378. SHMT. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR001085. Ser_HO-MeTrfase.
IPR019798. Ser_HO-MeTrfase_PLP_BS.
[Graphical view]
PANTHERiPTHR11680. PTHR11680. 1 hit.
PfamiPF00464. SHMT. 1 hit.
[Graphical view]
PIRSFiPIRSF000412. SHMT. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00096. SHMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q5BJF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ELRCCTSLCF GRLGLCRDVG SWSGWPFGLS TATQPRLRLG KQTGAGQARR
60 70 80 90 100
ACRTVILRCG SCCRGRRTGS VVAWSSLPQR YYGGAEVVDE IELLCQRRAL
110 120 130 140 150
EAFDLDPAQW GVNVQPYSGS PANLAVYTAL LQPHDRIMGL DLPDGGHLTH
160 170 180 190 200
GYMSDVKRIS ATSIFFESMP YKLNPKTGLI DYNQLALTAR LFRPRLIIAG
210 220 230 240 250
TSAYARLIDY ARMREVCDEV KAHLLADMAH ISGLVAAKVI PSPFKHADIV
260 270 280 290 300
TTTTHKTLRG ARSGLIFYRK GVKAVDPKTG REIPYTFEDR INFAVFPSLQ
310 320 330 340 350
GGPHNHAIAA VAVALKQACT PMFREYSLQV LKNARAMADA LLERGYSLVS
360 370 380 390 400
GGTDNHLVLV DLRPKGLDGA RAERVLELVS ITANKNTCPG DRSAITPGGL
410 420 430 440 450
RLGAPALTSR QFREDDFRRV VDFIDEGVNI GLEVKSKTAK LQDFKSFLLK
460 470 480
DSETSQRLAN LRQRVEQFAR AFPMPGFDEH
Length:480
Mass (Da):52,910
Last modified:April 12, 2005 - v1
Checksum:i1295CB9786042BE9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091501 mRNA. Translation: AAH91501.1.
RefSeqiNP_001159828.1. NM_001166356.1.
NP_001159829.1. NM_001166357.1.
NP_001159830.1. NM_001166358.1.
NP_001159831.1. NM_001166359.1.
NP_005403.2. NM_005412.5.
UniGeneiHs.741179.

Genome annotation databases

GeneIDi6472.
KEGGihsa:6472.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091501 mRNA. Translation: AAH91501.1.
RefSeqiNP_001159828.1. NM_001166356.1.
NP_001159829.1. NM_001166357.1.
NP_001159830.1. NM_001166358.1.
NP_001159831.1. NM_001166359.1.
NP_005403.2. NM_005412.5.
UniGeneiHs.741179.

3D structure databases

ProteinModelPortaliQ5BJF5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000333667.

Proteomic databases

PaxDbiQ5BJF5.
PeptideAtlasiQ5BJF5.
PRIDEiQ5BJF5.

Protocols and materials databases

DNASUi6472.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6472.
KEGGihsa:6472.

Organism-specific databases

CTDi6472.
PharmGKBiPA35755.

Phylogenomic databases

eggNOGiKOG2467. Eukaryota.
COG0112. LUCA.
HOVERGENiHBG002807.
KOiK00600.

Enzyme and pathway databases

UniPathwayiUPA00193.

Miscellaneous databases

ChiTaRSiSHMT2. human.
GenomeRNAii6472.

Gene expression databases

GenevisibleiQ5BJF5. HS.

Family and domain databases

CDDicd00378. SHMT. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR001085. Ser_HO-MeTrfase.
IPR019798. Ser_HO-MeTrfase_PLP_BS.
[Graphical view]
PANTHERiPTHR11680. PTHR11680. 1 hit.
PfamiPF00464. SHMT. 1 hit.
[Graphical view]
PIRSFiPIRSF000412. SHMT. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00096. SHMT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ5BJF5_HUMAN
AccessioniPrimary (citable) accession number: Q5BJF5
Entry historyi
Integrated into UniProtKB/TrEMBL: April 12, 2005
Last sequence update: April 12, 2005
Last modified: September 7, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.