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Protein

Transmembrane protein 41B

Gene

TMEM41B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for normal motor neuron development.By similarity

GO - Biological processi

Keywordsi

Biological processNeurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 41B
Gene namesi
Name:TMEM41B
Synonyms:KIAA0033
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000166471.10
HGNCiHGNC:28948 TMEM41B
neXtProtiNX_Q5BJD5

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Transmembranei109 – 129HelicalSequence analysisAdd BLAST21
Transmembranei147 – 169HelicalSequence analysisAdd BLAST23
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Transmembranei262 – 282HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000166471
PharmGKBiPA134898265

Polymorphism and mutation databases

BioMutaiTMEM41B
DMDMi74741383

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002919371 – 291Transmembrane protein 41BAdd BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphothreonineCombined sources1
Modified residuei35PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5BJD5
MaxQBiQ5BJD5
PaxDbiQ5BJD5
PeptideAtlasiQ5BJD5
PRIDEiQ5BJD5

PTM databases

iPTMnetiQ5BJD5
PhosphoSitePlusiQ5BJD5
SwissPalmiQ5BJD5

Expressioni

Gene expression databases

BgeeiENSG00000166471
CleanExiHS_TMEM41B
ExpressionAtlasiQ5BJD5 baseline and differential
GenevisibleiQ5BJD5 HS

Organism-specific databases

HPAiHPA014946

Interactioni

Protein-protein interaction databases

BioGridi136224, 7 interactors
IntActiQ5BJD5, 3 interactors
STRINGi9606.ENSP00000299596

Structurei

3D structure databases

ProteinModelPortaliQ5BJD5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM41 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3140 Eukaryota
COG0398 LUCA
GeneTreeiENSGT00520000055582
HOGENOMiHOG000240349
HOVERGENiHBG108584
InParanoidiQ5BJD5
OMAiKWSQQVD
OrthoDBiEOG091G0ONT
PhylomeDBiQ5BJD5
TreeFamiTF314301

Family and domain databases

InterProiView protein in InterPro
IPR032816 SNARE_assoc
PfamiView protein in Pfam
PF09335 SNARE_assoc, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5BJD5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKGRVAERS QLGAHHTTPV GDGAAGTRGL AAPGSRDHQK EKSWVEAGSA
60 70 80 90 100
RMSLLILVSI FLSAAFVMFL VYKNFPQLSE EERVNMKVPR DMDDAKALGK
110 120 130 140 150
VLSKYKDTFY VQVLVAYFAT YIFLQTFAIP GSIFLSILSG FLYPFPLALF
160 170 180 190 200
LVCLCSGLGA SFCYMLSYLV GRPVVYKYLT EKAVKWSQQV ERHREHLINY
210 220 230 240 250
IIFLRITPFL PNWFINITSP VINVPLKVFF IGTFLGVAPP SFVAIKAGTT
260 270 280 290
LYQLTTAGEA VSWNSIFILM ILAVLSILPA IFQKKLKQKF E
Length:291
Mass (Da):32,513
Last modified:April 12, 2005 - v1
Checksum:iD782FBAF1698CD85
GO
Isoform 2 (identifier: Q5BJD5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-192: LQTFAIPGSI...AVKWSQQVER → YQLANICYSR...RESSKMVTAG
     193-291: Missing.

Note: No experimental confirmation available.
Show »
Length:192
Mass (Da):21,662
Checksum:i72688F12525B1782
GO
Isoform 3 (identifier: Q5BJD5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-127: FLQTF → LYPFN
     128-291: Missing.

Note: No experimental confirmation available.
Show »
Length:127
Mass (Da):14,089
Checksum:iE9D567898DF95338
GO

Sequence cautioni

The sequence BAA05062 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_045268123 – 127FLQTF → LYPFN in isoform 3. 1 Publication5
Alternative sequenceiVSP_026316124 – 192LQTFA…QQVER → YQLANICYSRLYISQYTLRV SLSLSTSLISCLFVFWTWCL FLLYAFLFSWETSCIQIPNR ESSKMVTAG in isoform 2. 1 PublicationAdd BLAST69
Alternative sequenceiVSP_045269128 – 291Missing in isoform 3. 1 PublicationAdd BLAST164
Alternative sequenceiVSP_026317193 – 291Missing in isoform 2. 1 PublicationAdd BLAST99

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26067 mRNA Translation: BAA05062.1 Different initiation.
DA149513 mRNA No translation available.
AC055845 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68594.1
CH471064 Genomic DNA Translation: EAW68597.1
BC035034 mRNA Translation: AAH35034.1
BC044597 mRNA Translation: AAH44597.1
BC091524 mRNA Translation: AAH91524.1
CCDSiCCDS31424.1 [Q5BJD5-1]
CCDS53600.1 [Q5BJD5-3]
RefSeqiNP_001158502.1, NM_001165030.2 [Q5BJD5-3]
NP_055827.1, NM_015012.3 [Q5BJD5-1]
UniGeneiHs.594563
Hs.731960

Genome annotation databases

EnsembliENST00000299596; ENSP00000299596; ENSG00000166471 [Q5BJD5-1]
ENST00000524543; ENSP00000431934; ENSG00000166471 [Q5BJD5-2]
ENST00000528080; ENSP00000433126; ENSG00000166471 [Q5BJD5-1]
ENST00000533723; ENSP00000436480; ENSG00000166471 [Q5BJD5-3]
ENST00000611268; ENSP00000480141; ENSG00000166471 [Q5BJD5-1]
GeneIDi440026
KEGGihsa:440026
UCSCiuc001mhm.5 human [Q5BJD5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTM41B_HUMAN
AccessioniPrimary (citable) accession number: Q5BJD5
Secondary accession number(s): D3DQU9
, E9PP29, Q15055, Q4G0P0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: April 12, 2005
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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