Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transmembrane protein 41B

Gene

TMEM41B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for normal motor neuron development.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 41B
Gene namesi
Name:TMEM41B
Synonyms:KIAA0033
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:28948. TMEM41B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Transmembranei109 – 129HelicalSequence analysisAdd BLAST21
Transmembranei147 – 169HelicalSequence analysisAdd BLAST23
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Transmembranei262 – 282HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000166471.
PharmGKBiPA134898265.

Polymorphism and mutation databases

BioMutaiTMEM41B.
DMDMi74741383.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002919371 – 291Transmembrane protein 41BAdd BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphothreonineCombined sources1
Modified residuei35PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5BJD5.
MaxQBiQ5BJD5.
PaxDbiQ5BJD5.
PeptideAtlasiQ5BJD5.
PRIDEiQ5BJD5.

PTM databases

iPTMnetiQ5BJD5.
PhosphoSitePlusiQ5BJD5.
SwissPalmiQ5BJD5.

Expressioni

Gene expression databases

BgeeiENSG00000166471.
CleanExiHS_TMEM41B.
ExpressionAtlasiQ5BJD5. baseline and differential.
GenevisibleiQ5BJD5. HS.

Organism-specific databases

HPAiHPA014946.

Interactioni

Protein-protein interaction databases

BioGridi136224. 6 interactors.
IntActiQ5BJD5. 3 interactors.
STRINGi9606.ENSP00000299596.

Structurei

3D structure databases

ProteinModelPortaliQ5BJD5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM41 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3140. Eukaryota.
COG0398. LUCA.
GeneTreeiENSGT00520000055582.
HOGENOMiHOG000240349.
HOVERGENiHBG108584.
InParanoidiQ5BJD5.
OMAiAYVFLQT.
OrthoDBiEOG091G0ONT.
PhylomeDBiQ5BJD5.
TreeFamiTF314301.

Family and domain databases

InterProiIPR032816. SNARE_assoc.
IPR015414. TMEM64/TMEM41.
[Graphical view]
PANTHERiPTHR12677. PTHR12677. 1 hit.
PfamiPF09335. SNARE_assoc. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5BJD5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKGRVAERS QLGAHHTTPV GDGAAGTRGL AAPGSRDHQK EKSWVEAGSA
60 70 80 90 100
RMSLLILVSI FLSAAFVMFL VYKNFPQLSE EERVNMKVPR DMDDAKALGK
110 120 130 140 150
VLSKYKDTFY VQVLVAYFAT YIFLQTFAIP GSIFLSILSG FLYPFPLALF
160 170 180 190 200
LVCLCSGLGA SFCYMLSYLV GRPVVYKYLT EKAVKWSQQV ERHREHLINY
210 220 230 240 250
IIFLRITPFL PNWFINITSP VINVPLKVFF IGTFLGVAPP SFVAIKAGTT
260 270 280 290
LYQLTTAGEA VSWNSIFILM ILAVLSILPA IFQKKLKQKF E
Length:291
Mass (Da):32,513
Last modified:April 12, 2005 - v1
Checksum:iD782FBAF1698CD85
GO
Isoform 2 (identifier: Q5BJD5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-192: LQTFAIPGSI...AVKWSQQVER → YQLANICYSR...RESSKMVTAG
     193-291: Missing.

Note: No experimental confirmation available.
Show »
Length:192
Mass (Da):21,662
Checksum:i72688F12525B1782
GO
Isoform 3 (identifier: Q5BJD5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-127: FLQTF → LYPFN
     128-291: Missing.

Note: No experimental confirmation available.
Show »
Length:127
Mass (Da):14,089
Checksum:iE9D567898DF95338
GO

Sequence cautioni

The sequence BAA05062 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_045268123 – 127FLQTF → LYPFN in isoform 3. 1 Publication5
Alternative sequenceiVSP_026316124 – 192LQTFA…QQVER → YQLANICYSRLYISQYTLRV SLSLSTSLISCLFVFWTWCL FLLYAFLFSWETSCIQIPNR ESSKMVTAG in isoform 2. 1 PublicationAdd BLAST69
Alternative sequenceiVSP_045269128 – 291Missing in isoform 3. 1 PublicationAdd BLAST164
Alternative sequenceiVSP_026317193 – 291Missing in isoform 2. 1 PublicationAdd BLAST99

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26067 mRNA. Translation: BAA05062.1. Different initiation.
DA149513 mRNA. No translation available.
AC055845 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68594.1.
CH471064 Genomic DNA. Translation: EAW68597.1.
BC035034 mRNA. Translation: AAH35034.1.
BC044597 mRNA. Translation: AAH44597.1.
BC091524 mRNA. Translation: AAH91524.1.
CCDSiCCDS31424.1. [Q5BJD5-1]
CCDS53600.1. [Q5BJD5-3]
RefSeqiNP_001158502.1. NM_001165030.2. [Q5BJD5-3]
NP_055827.1. NM_015012.3. [Q5BJD5-1]
UniGeneiHs.594563.
Hs.731960.

Genome annotation databases

EnsembliENST00000299596; ENSP00000299596; ENSG00000166471. [Q5BJD5-1]
ENST00000524543; ENSP00000431934; ENSG00000166471. [Q5BJD5-2]
ENST00000528080; ENSP00000433126; ENSG00000166471. [Q5BJD5-1]
ENST00000533723; ENSP00000436480; ENSG00000166471. [Q5BJD5-3]
ENST00000611268; ENSP00000480141; ENSG00000166471. [Q5BJD5-1]
GeneIDi440026.
KEGGihsa:440026.
UCSCiuc001mhm.5. human. [Q5BJD5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26067 mRNA. Translation: BAA05062.1. Different initiation.
DA149513 mRNA. No translation available.
AC055845 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68594.1.
CH471064 Genomic DNA. Translation: EAW68597.1.
BC035034 mRNA. Translation: AAH35034.1.
BC044597 mRNA. Translation: AAH44597.1.
BC091524 mRNA. Translation: AAH91524.1.
CCDSiCCDS31424.1. [Q5BJD5-1]
CCDS53600.1. [Q5BJD5-3]
RefSeqiNP_001158502.1. NM_001165030.2. [Q5BJD5-3]
NP_055827.1. NM_015012.3. [Q5BJD5-1]
UniGeneiHs.594563.
Hs.731960.

3D structure databases

ProteinModelPortaliQ5BJD5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi136224. 6 interactors.
IntActiQ5BJD5. 3 interactors.
STRINGi9606.ENSP00000299596.

PTM databases

iPTMnetiQ5BJD5.
PhosphoSitePlusiQ5BJD5.
SwissPalmiQ5BJD5.

Polymorphism and mutation databases

BioMutaiTMEM41B.
DMDMi74741383.

Proteomic databases

EPDiQ5BJD5.
MaxQBiQ5BJD5.
PaxDbiQ5BJD5.
PeptideAtlasiQ5BJD5.
PRIDEiQ5BJD5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299596; ENSP00000299596; ENSG00000166471. [Q5BJD5-1]
ENST00000524543; ENSP00000431934; ENSG00000166471. [Q5BJD5-2]
ENST00000528080; ENSP00000433126; ENSG00000166471. [Q5BJD5-1]
ENST00000533723; ENSP00000436480; ENSG00000166471. [Q5BJD5-3]
ENST00000611268; ENSP00000480141; ENSG00000166471. [Q5BJD5-1]
GeneIDi440026.
KEGGihsa:440026.
UCSCiuc001mhm.5. human. [Q5BJD5-1]

Organism-specific databases

CTDi440026.
GeneCardsiTMEM41B.
HGNCiHGNC:28948. TMEM41B.
HPAiHPA014946.
neXtProtiNX_Q5BJD5.
OpenTargetsiENSG00000166471.
PharmGKBiPA134898265.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3140. Eukaryota.
COG0398. LUCA.
GeneTreeiENSGT00520000055582.
HOGENOMiHOG000240349.
HOVERGENiHBG108584.
InParanoidiQ5BJD5.
OMAiAYVFLQT.
OrthoDBiEOG091G0ONT.
PhylomeDBiQ5BJD5.
TreeFamiTF314301.

Miscellaneous databases

ChiTaRSiTMEM41B. human.
GenomeRNAii440026.
PROiQ5BJD5.

Gene expression databases

BgeeiENSG00000166471.
CleanExiHS_TMEM41B.
ExpressionAtlasiQ5BJD5. baseline and differential.
GenevisibleiQ5BJD5. HS.

Family and domain databases

InterProiIPR032816. SNARE_assoc.
IPR015414. TMEM64/TMEM41.
[Graphical view]
PANTHERiPTHR12677. PTHR12677. 1 hit.
PfamiPF09335. SNARE_assoc. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM41B_HUMAN
AccessioniPrimary (citable) accession number: Q5BJD5
Secondary accession number(s): D3DQU9
, E9PP29, Q15055, Q4G0P0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: April 12, 2005
Last modified: November 30, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.