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Protein

Interleukin-17F

Gene

Il17f

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover. Also involved in stimulating proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis. Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17F
Short name:
IL-17F
Gene namesi
Name:Il17f
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1311398. Il17f.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828By similarityAdd
BLAST
Chaini29 – 161133Interleukin-17FPRO_0000378105Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi45 – 45Interchain (with C-135)By similarity
Glycosylationi83 – 831N-linked (GlcNAc...)By similarity
Disulfide bondi100 ↔ 150By similarity
Disulfide bondi105 ↔ 152By similarity
Disulfide bondi135 – 135Interchain (with C-35)By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5BJ95.
PRIDEiQ5BJ95.

Expressioni

Gene expression databases

GenevisibleiQ5BJ95. RN.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Heterodimer with IL17A.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016717.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-17 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYVF. Eukaryota.
ENOG410YVBI. LUCA.
HOGENOMiHOG000064520.
InParanoidiQ5BJ95.
KOiK05494.
OMAiCPPLEDN.
OrthoDBiEOG70089V.
PhylomeDBiQ5BJ95.
TreeFamiTF314701.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020440. IL-17_chr.
IPR010345. IL-17_fam.
[Graphical view]
PANTHERiPTHR21295. PTHR21295. 1 hit.
PfamiPF06083. IL17. 1 hit.
[Graphical view]
PRINTSiPR01932. INTRLEUKIN17.
SUPFAMiSSF57501. SSF57501. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5BJ95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGSCETTMV KSLLLLMLGF AIISSGAARR NPKVGLSALQ KAGNCPPLED
60 70 80 90 100
NSVRVDIRIF NQNQGISVPR DFQNRSSSPW DYNITRDPDR FPSEIAEAQC
110 120 130 140 150
RHSGCINAQG QEDGSMNSVP IQQEILVLRR EPQGCSNSFR LEKMLIKVGC
160
TCVTPIVHHA A
Length:161
Mass (Da):17,712
Last modified:June 16, 2009 - v2
Checksum:i8F1ACDD70FA84860
GO

Sequence cautioni

The sequence AAH91568.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091568 mRNA. Translation: AAH91568.1. Different initiation.
RefSeqiNP_001015011.2. NM_001015011.2.
UniGeneiRn.34022.

Genome annotation databases

GeneIDi301291.
KEGGirno:301291.
UCSCiRGD:1311398. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091568 mRNA. Translation: AAH91568.1. Different initiation.
RefSeqiNP_001015011.2. NM_001015011.2.
UniGeneiRn.34022.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016717.

Proteomic databases

PaxDbiQ5BJ95.
PRIDEiQ5BJ95.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi301291.
KEGGirno:301291.
UCSCiRGD:1311398. rat.

Organism-specific databases

CTDi112744.
RGDi1311398. Il17f.

Phylogenomic databases

eggNOGiENOG410IYVF. Eukaryota.
ENOG410YVBI. LUCA.
HOGENOMiHOG000064520.
InParanoidiQ5BJ95.
KOiK05494.
OMAiCPPLEDN.
OrthoDBiEOG70089V.
PhylomeDBiQ5BJ95.
TreeFamiTF314701.

Miscellaneous databases

NextBioi648502.
PROiQ5BJ95.

Gene expression databases

GenevisibleiQ5BJ95. RN.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020440. IL-17_chr.
IPR010345. IL-17_fam.
[Graphical view]
PANTHERiPTHR21295. PTHR21295. 1 hit.
PfamiPF06083. IL17. 1 hit.
[Graphical view]
PRINTSiPR01932. INTRLEUKIN17.
SUPFAMiSSF57501. SSF57501. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiIL17F_RAT
AccessioniPrimary (citable) accession number: Q5BJ95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: June 16, 2009
Last modified: May 11, 2016
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.