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Protein

Interleukin-17F

Gene

Il17f

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover. Also involved in stimulating proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis. Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17F
Short name:
IL-17F
Gene namesi
Name:Il17f
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1311398 Il17f

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28By similarityAdd BLAST28
ChainiPRO_000037810529 – 161Interleukin-17FAdd BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi45Interchain (with C-135)By similarity
Glycosylationi83N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi100 ↔ 150By similarity
Disulfide bondi105 ↔ 152By similarity
Disulfide bondi135Interchain (with C-35)By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5BJ95
PRIDEiQ5BJ95

PTM databases

iPTMnetiQ5BJ95
PhosphoSitePlusiQ5BJ95

Expressioni

Gene expression databases

GenevisibleiQ5BJ95 RN

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Heterodimer with IL17A.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016717

Structurei

3D structure databases

SMRiQ5BJ95
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-17 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYVF Eukaryota
ENOG410YVBI LUCA
HOGENOMiHOG000064520
InParanoidiQ5BJ95
KOiK05494
OrthoDBiEOG091G0RG1
PhylomeDBiQ5BJ95
TreeFamiTF314701

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR020440 IL-17_chr
IPR010345 IL-17_fam
PfamiView protein in Pfam
PF06083 IL17, 1 hit
PRINTSiPR01932 INTRLEUKIN17
SUPFAMiSSF57501 SSF57501, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5BJ95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGSCETTMV KSLLLLMLGF AIISSGAARR NPKVGLSALQ KAGNCPPLED
60 70 80 90 100
NSVRVDIRIF NQNQGISVPR DFQNRSSSPW DYNITRDPDR FPSEIAEAQC
110 120 130 140 150
RHSGCINAQG QEDGSMNSVP IQQEILVLRR EPQGCSNSFR LEKMLIKVGC
160
TCVTPIVHHA A
Length:161
Mass (Da):17,712
Last modified:June 16, 2009 - v2
Checksum:i8F1ACDD70FA84860
GO

Sequence cautioni

The sequence AAH91568 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091568 mRNA Translation: AAH91568.1 Different initiation.
RefSeqiNP_001015011.2, NM_001015011.2
UniGeneiRn.34022

Genome annotation databases

GeneIDi301291
KEGGirno:301291
UCSCiRGD:1311398 rat

Similar proteinsi

Entry informationi

Entry nameiIL17F_RAT
AccessioniPrimary (citable) accession number: Q5BJ95
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: June 16, 2009
Last modified: May 23, 2018
This is version 80 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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