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Protein

F-box/LRR-repeat protein 7

Gene

Fbxl7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • cell proliferation Source: UniProtKB
  • G2/M transition of mitotic cell cycle Source: UniProtKB
  • mitotic nuclear division Source: UniProtKB
  • protein ubiquitination Source: UniProtKB
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 7
Alternative name(s):
F-box and leucine-rich repeat protein 7
Gene namesi
Name:Fbxl7
Synonyms:Kiaa0840
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:3052506. Fbxl7.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • cytoplasm Source: UniProtKB-KW
  • SCF ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491F-box/LRR-repeat protein 7PRO_0000307720Add
BLAST

Proteomic databases

PaxDbiQ5BJ29.
PRIDEiQ5BJ29.

PTM databases

iPTMnetiQ5BJ29.
PhosphoSiteiQ5BJ29.

Expressioni

Gene expression databases

BgeeiQ5BJ29.
CleanExiMM_FBXL7.
GenevisibleiQ5BJ29. MM.

Interactioni

Subunit structurei

Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL7) composed of CUL1, SKP1, RBX1 and FBXL7. Interacts with AURKA; interaction takes place during mitosis but not in interphase.1 Publication

Protein-protein interaction databases

BioGridi243078. 1 interaction.
IntActiQ5BJ29. 1 interaction.
STRINGi10090.ENSMUSP00000061305.

Structurei

3D structure databases

ProteinModelPortaliQ5BJ29.
SMRiQ5BJ29. Positions 113-470.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini111 – 15747F-boxPROSITE-ProRule annotationAdd
BLAST
Repeati185 – 21026LRR 1Add
BLAST
Repeati211 – 23626LRR 2Add
BLAST
Repeati237 – 26226LRR 3Add
BLAST
Repeati271 – 29626LRR 4Add
BLAST
Repeati297 – 32226LRR 5Add
BLAST
Repeati323 – 34826LRR 6Add
BLAST
Repeati349 – 37426LRR 7Add
BLAST
Repeati375 – 40026LRR 8Add
BLAST
Repeati401 – 42626LRR 9Add
BLAST
Repeati427 – 45226LRR 10Add
BLAST

Sequence similaritiesi

Belongs to the FBXL7 family.Curated
Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 10 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IT22. Eukaryota.
ENOG410YA1Y. LUCA.
GeneTreeiENSGT00760000119059.
HOGENOMiHOG000116328.
HOVERGENiHBG051591.
InParanoidiQ5BJ29.
KOiK10273.
OMAiLMLETVI.
OrthoDBiEOG75MVWQ.
PhylomeDBiQ5BJ29.
TreeFamiTF313434.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF13516. LRR_6. 5 hits.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00367. LRR_CC. 10 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5BJ29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGANNGKQYG SEGKGSSSVS SDVSSSTDHT PTKAQRNVAT SEDSDLSMRT
60 70 80 90 100
LSTPSPALIC PPTLPGFQNG RGSSTSSSSI TGETVAMVHS PPPTRLTHPL
110 120 130 140 150
IRLASRPQKE QASIDRLPDH SMVQIFSFLP TNQLCRCARV CRRWYNLAWD
160 170 180 190 200
PRLWRTIRLT GETINVDRAL KVLTRRLCQD TPNVCLMLET VIVSGCRRLT
210 220 230 240 250
DRGLYTIAQC CPELRRLEVS GCYNISNEAV FDVVSLCPNL EHLDVSGCSK
260 270 280 290 300
VTCISLTREA SIKLSPLHGK QISIRYLDMT DCFVLEDEGL HTIAAHCTQL
310 320 330 340 350
THLYLRRCVR LTDEGLRYLV IYCTSIKELS VSDCRFVSDF GLREIAKLES
360 370 380 390 400
RLRYLSIAHC GRITDVGIRY VAKYCSKLRY LNARGCEGIT DHGVEYLAKN
410 420 430 440 450
CTKLKSLDIG KCPLVSDTGL ESLALNCFNL KRLSLKSCES ITGQGLQIVA
460 470 480 490
ANCFDLQMLN VQDCEVSVEA LRFVKRHCKR CVIEHTNPAF F
Length:491
Mass (Da):54,646
Last modified:April 12, 2005 - v1
Checksum:i52EC5B2A00EDC1E6
GO

Sequence cautioni

The sequence BAC98037.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129227 mRNA. Translation: BAC98037.1. Different initiation.
BC091646 mRNA. Translation: AAH91646.1.
CCDSiCCDS37052.1.
RefSeqiNP_795933.2. NM_176959.3.
UniGeneiMm.253378.

Genome annotation databases

EnsembliENSMUST00000059204; ENSMUSP00000061305; ENSMUSG00000043556.
GeneIDi448987.
KEGGimmu:448987.
UCSCiuc007vjn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129227 mRNA. Translation: BAC98037.1. Different initiation.
BC091646 mRNA. Translation: AAH91646.1.
CCDSiCCDS37052.1.
RefSeqiNP_795933.2. NM_176959.3.
UniGeneiMm.253378.

3D structure databases

ProteinModelPortaliQ5BJ29.
SMRiQ5BJ29. Positions 113-470.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi243078. 1 interaction.
IntActiQ5BJ29. 1 interaction.
STRINGi10090.ENSMUSP00000061305.

PTM databases

iPTMnetiQ5BJ29.
PhosphoSiteiQ5BJ29.

Proteomic databases

PaxDbiQ5BJ29.
PRIDEiQ5BJ29.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059204; ENSMUSP00000061305; ENSMUSG00000043556.
GeneIDi448987.
KEGGimmu:448987.
UCSCiuc007vjn.1. mouse.

Organism-specific databases

CTDi23194.
MGIiMGI:3052506. Fbxl7.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IT22. Eukaryota.
ENOG410YA1Y. LUCA.
GeneTreeiENSGT00760000119059.
HOGENOMiHOG000116328.
HOVERGENiHBG051591.
InParanoidiQ5BJ29.
KOiK10273.
OMAiLMLETVI.
OrthoDBiEOG75MVWQ.
PhylomeDBiQ5BJ29.
TreeFamiTF313434.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ5BJ29.
SOURCEiSearch...

Gene expression databases

BgeeiQ5BJ29.
CleanExiMM_FBXL7.
GenevisibleiQ5BJ29. MM.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF13516. LRR_6. 5 hits.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00367. LRR_CC. 10 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryonic tail.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  3. "Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest."
    Coon T.A., Glasser J.R., Mallampalli R.K., Chen B.B.
    Cell Cycle 11:721-729(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION IN A SCF PROTEIN LIGASE COMPLEX, INTERACTION WITH AURKA.

Entry informationi

Entry nameiFBXL7_MOUSE
AccessioniPrimary (citable) accession number: Q5BJ29
Secondary accession number(s): Q6ZQ36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: April 12, 2005
Last modified: June 8, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.