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Protein

Alsin

Gene

ALS2

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Alsin
Alternative name(s):
Amyotrophic lateral sclerosis 2 protein homolog
Gene namesi
Name:ALS2
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16571657AlsinPRO_0000080905Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei465 – 4651PhosphoserineBy similarity
Modified residuei466 – 4661PhosphoserineBy similarity
Modified residuei483 – 4831PhosphoserineBy similarity
Modified residuei492 – 4921PhosphoserineBy similarity
Modified residuei510 – 5101PhosphothreonineBy similarity
Modified residuei533 – 5331N6-acetyllysineBy similarity
Modified residuei1335 – 13351PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5BIW4.
PRIDEiQ5BIW4.

Interactioni

Subunit structurei

Forms a heteromeric complex with ALS2CL. Interacts with ALS2CL (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000021899.

Structurei

3D structure databases

ProteinModelPortaliQ5BIW4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati60 – 10950RCC1 1Add
BLAST
Repeati110 – 16859RCC1 2Add
BLAST
Repeati169 – 21951RCC1 3Add
BLAST
Repeati526 – 57752RCC1 4Add
BLAST
Repeati578 – 62851RCC1 5Add
BLAST
Domaini690 – 885196DHPROSITE-ProRule annotationAdd
BLAST
Domaini901 – 1007107PHAdd
BLAST
Repeati1049 – 107123MORN 1Add
BLAST
Repeati1072 – 109423MORN 2Add
BLAST
Repeati1100 – 112223MORN 3Add
BLAST
Repeati1123 – 114523MORN 4Add
BLAST
Repeati1151 – 117323MORN 5Add
BLAST
Repeati1175 – 119723MORN 6Add
BLAST
Repeati1198 – 122023MORN 7Add
BLAST
Repeati1221 – 124424MORN 8Add
BLAST
Domaini1513 – 1657145VPS9PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 8 MORN repeats.Curated
Contains 1 PH domain.Curated
Contains 5 RCC1 repeats.PROSITE-ProRule annotation
Contains 1 VPS9 domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0231. Eukaryota.
KOG1426. Eukaryota.
COG4642. LUCA.
HOGENOMiHOG000033908.
HOVERGENiHBG037320.
InParanoidiQ5BIW4.
KOiK04575.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.130.10.30. 2 hits.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR003409. MORN.
IPR011993. PH_dom-like.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
IPR003123. VPS9.
[Graphical view]
PfamiPF02493. MORN. 8 hits.
PF00415. RCC1. 4 hits.
PF00621. RhoGEF. 1 hit.
PF02204. VPS9. 1 hit.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SMARTiSM00698. MORN. 8 hits.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF50985. SSF50985. 2 hits.
PROSITEiPS50010. DH_2. 1 hit.
PS00626. RCC1_2. 2 hits.
PS50012. RCC1_3. 5 hits.
PS51205. VPS9. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5BIW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSKKRSSTE AEGSKERGLV HIWQAGSFPI TPERLPGWGG KTVLQAALGV
60 70 80 90 100
KHGVLLTEDG EVYSFGTLPW RSGPVEICPS SPILENALVG QYVVTVATGS
110 120 130 140 150
FHSGAVTDNG VAYMWGENSA GQCAVANQQY VPEPNPVSIA DSEASPLLAV
160 170 180 190 200
RILQLACGEE HTLALSISRE IWAWGTGCQL GLITTAFPVT KPQKVEHLAG
210 220 230 240 250
RVVLQVACGA FHSLALVQCL PSQDLKPVPE RCNQCSQLLI TMTDKEDHVI
260 270 280 290 300
ISDSHCCPLG VTLTESQAEN HASTALSPST ETLDRQEEVF ENTLVANDQS
310 320 330 340 350
VATELNAVSA QITSSDAMSS QQNVMGTTEI SSARNIPSYP DTQAVNEYLR
360 370 380 390 400
KLSDHSVRED SEHGEKPMPS QPLLEEAIPN LHSPPTTSTS ALNSLVVSCA
410 420 430 440 450
SAVGVRVAAT YEAGALSLKK VMNFYSTTPC ETGAQAGSSA IGPEGLKDSR
460 470 480 490 500
EEQVKQESMQ GKKSSSLVDI REEETEGGSR RLSLPGLLSQ VSPRLLRKAA
510 520 530 540 550
RVKTRTVVLT PTYSGEADAL LPSLRTEVWT WGKGKEGQLG HGDVLPRLQP
560 570 580 590 600
LCVKCLDGKE VIHLEAGGYH SLALTAKSQV YSWGSNTFGQ LGHSDFPTTV
610 620 630 640 650
PRLAKISSEN GVWSVAAGRD YSLFLVDTED FQPGLYYSGR QDPTEGDNLP
660 670 680 690 700
ENHSGSKTPV LLSCSKLGYI SRVTAGKDSY LALVDKNIMG YIASLHELAT
710 720 730 740 750
TERRFYSKLS DIKSQILRPL LSLENLGTTT TVQLLQEVAS RFSKLCYLIG
760 770 780 790 800
QHGASLSSFL HGVKEARSLV ILKHSSLFLD SYTEYCTSIT NFLVMGGFQL
810 820 830 840 850
LAKPAIDFLN KNQELLQDLS EVNDENTQLM EILNTLFFLP IRRLHNYAKV
860 870 880 890 900
LLKLATCFEV ASPEYQKLQD SSSCYECLAL HLGRKRKEAE YTLGFWKTFP
910 920 930 940 950
GKMTDSLRKP ERRLLCESSN RALSLQHAGR FSVNWFILFN DALVHAQFST
960 970 980 990 1000
HHVFPLATLW AEPLSEEAGG VNGLKITTPE EQFTLISSTP QEKTKWLRAI
1010 1020 1030 1040 1050
SQAVDQALRG MSDLPPYGSG SSVQRQEPPI SRSAKYTFYK DPRLKDATYD
1060 1070 1080 1090 1100
GRWLSGKPHG RGVLKWPDGK MYSGMFRNGL EDGYGEYRIP NKAMNKEDHY
1110 1120 1130 1140 1150
VGHWKEGKMC GQGVYSYASG EVFEGCFQDN MRHGHGLLRS GKLTSSSPSM
1160 1170 1180 1190 1200
FIGQWVMDKK AGYGVFDDIT RGEKYMGMWQ DDVCQGNGVV VTQFGLYYEG
1210 1220 1230 1240 1250
NFHLNKMMGN GVLLSEDDTI YEGEFSDDWT LSGKGTLTMP NGDYIEGYFS
1260 1270 1280 1290 1300
GEWGSGIKIT GTYFKPSLYE SDKDRPKVFR KLRNLAVPAD EKWKAVFDEC
1310 1320 1330 1340 1350
WRQLGCEGPG QGEVWKAWDN IAVALTTSRR QHRDSPEILS RSQTQTLESL
1360 1370 1380 1390 1400
EFIPQHVGAF SVEKYDDIRK YLIKACDTPL HPLGRLVETL VAVYRMTYVG
1410 1420 1430 1440 1450
VGANRRLLQE AVKEIKSYLK RIFQLVRFLF PELPEEGSTI PLSAPLPTER
1460 1470 1480 1490 1500
KSFCTGKSDS RSESPEPGYV VTSSGLLLPV LLPRLYPPLF MLYALDNDRE
1510 1520 1530 1540 1550
EDIYWECVLR LNKQPDIALL GFLGVQRKFW PATLSILGES KKVLPTTKDA
1560 1570 1580 1590 1600
CFASAVECLQ QISTTFTPSD KLKVIQQTFE EISQSVLASL HEDFLWSMDD
1610 1620 1630 1640 1650
LFPVFLYVVL RARIRNLGSE VHLIEDLMDP YLQHGEQGIM FTTLKACYYQ

IQREKLN
Length:1,657
Mass (Da):183,737
Last modified:April 12, 2005 - v1
Checksum:i2D585F9C57ADF8DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BK005194 mRNA. Translation: DAA05675.1.
RefSeqiNP_001073389.1. NM_001079920.1.
UniGeneiPtr.813.

Genome annotation databases

GeneIDi470613.
KEGGiptr:470613.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BK005194 mRNA. Translation: DAA05675.1.
RefSeqiNP_001073389.1. NM_001079920.1.
UniGeneiPtr.813.

3D structure databases

ProteinModelPortaliQ5BIW4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000021899.

Proteomic databases

PaxDbiQ5BIW4.
PRIDEiQ5BIW4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi470613.
KEGGiptr:470613.

Organism-specific databases

CTDi57679.

Phylogenomic databases

eggNOGiKOG0231. Eukaryota.
KOG1426. Eukaryota.
COG4642. LUCA.
HOGENOMiHOG000033908.
HOVERGENiHBG037320.
InParanoidiQ5BIW4.
KOiK04575.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.130.10.30. 2 hits.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR003409. MORN.
IPR011993. PH_dom-like.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
IPR003123. VPS9.
[Graphical view]
PfamiPF02493. MORN. 8 hits.
PF00415. RCC1. 4 hits.
PF00621. RhoGEF. 1 hit.
PF02204. VPS9. 1 hit.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SMARTiSM00698. MORN. 8 hits.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF50985. SSF50985. 2 hits.
PROSITEiPS50010. DH_2. 1 hit.
PS00626. RCC1_2. 2 hits.
PS50012. RCC1_3. 5 hits.
PS51205. VPS9. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALS2_PANTR
AccessioniPrimary (citable) accession number: Q5BIW4
Secondary accession number(s): Q29R55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: April 12, 2005
Last modified: July 6, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.