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Protein

Shadow of prion protein

Gene

SPRN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Prion

Names & Taxonomyi

Protein namesi
Recommended name:
Shadow of prion protein
Short name:
Protein shadoo
Gene namesi
Name:SPRN
Synonyms:SHO
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:16871. SPRN.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Amyloid, Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670876.

Polymorphism and mutation databases

BioMutaiSPRN.
DMDMi74722519.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 126102Shadow of prion proteinPRO_5000096015Add
BLAST
Propeptidei127 – 15125Removed in mature formSequence analysisPRO_0000320166Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence analysis
Lipidationi126 – 1261GPI-anchor amidated glycineSequence analysis

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ5BIV9.
PeptideAtlasiQ5BIV9.
PRIDEiQ5BIV9.

PTM databases

iPTMnetiQ5BIV9.
PhosphoSiteiQ5BIV9.

Expressioni

Tissue specificityi

Mainly expressed in brain. In brain, it is expressed in hippocampus.1 Publication

Gene expression databases

BgeeiQ5BIV9.
CleanExiHS_SPRN.
GenevisibleiQ5BIV9. HS.

Interactioni

Protein-protein interaction databases

IntActiQ5BIV9. 1 interaction.
STRINGi9606.ENSP00000433712.

Structurei

3D structure databases

ProteinModelPortaliQ5BIV9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4 – 9390Ala-richAdd
BLAST

Sequence similaritiesi

Belongs to the SPRN family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JEZN. Eukaryota.
ENOG41114XD. LUCA.
GeneTreeiENSGT00730000111694.
HOVERGENiHBG054918.
InParanoidiQ5BIV9.
OMAiTCWALLL.
OrthoDBiEOG7BZVWQ.
PhylomeDBiQ5BIV9.
TreeFamiTF330766.

Family and domain databases

InterProiIPR029238. Shadoo.
[Graphical view]
PfamiPF14999. Shadoo. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5BIV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNWAPATCWA LLLAAAFLCD SGAAKGGRGG ARGSARGGVR GGARGASRVR
60 70 80 90 100
VRPAQRYGAP GSSLRVAAAG AAAGAAAGAA AGLAAGSGWR RAAGPGERGL
110 120 130 140 150
EDEEDGVPGG NGTGPGIYSY RAWTSGAGPT RGPRLCLVLG GALGALGLLR

P
Length:151
Mass (Da):14,522
Last modified:April 12, 2005 - v1
Checksum:iAE545DB777F9110E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71T → M.
Corresponds to variant rs2492666 [ dbSNP | Ensembl ].
VAR_039152

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC040198 mRNA. Translation: AAH40198.1.
BN000518 Genomic DNA. Translation: CAG34288.1.
CCDSiCCDS53589.1.
RefSeqiNP_001012526.2. NM_001012508.3.
XP_005252741.1. XM_005252684.3.
UniGeneiHs.64968.

Genome annotation databases

EnsembliENST00000414069; ENSP00000433712; ENSG00000203772.
GeneIDi503542.
KEGGihsa:503542.
UCSCiuc001lnf.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC040198 mRNA. Translation: AAH40198.1.
BN000518 Genomic DNA. Translation: CAG34288.1.
CCDSiCCDS53589.1.
RefSeqiNP_001012526.2. NM_001012508.3.
XP_005252741.1. XM_005252684.3.
UniGeneiHs.64968.

3D structure databases

ProteinModelPortaliQ5BIV9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5BIV9. 1 interaction.
STRINGi9606.ENSP00000433712.

PTM databases

iPTMnetiQ5BIV9.
PhosphoSiteiQ5BIV9.

Polymorphism and mutation databases

BioMutaiSPRN.
DMDMi74722519.

Proteomic databases

PaxDbiQ5BIV9.
PeptideAtlasiQ5BIV9.
PRIDEiQ5BIV9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000414069; ENSP00000433712; ENSG00000203772.
GeneIDi503542.
KEGGihsa:503542.
UCSCiuc001lnf.5. human.

Organism-specific databases

CTDi503542.
GeneCardsiSPRN.
HGNCiHGNC:16871. SPRN.
MIMi610447. gene.
neXtProtiNX_Q5BIV9.
PharmGKBiPA142670876.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JEZN. Eukaryota.
ENOG41114XD. LUCA.
GeneTreeiENSGT00730000111694.
HOVERGENiHBG054918.
InParanoidiQ5BIV9.
OMAiTCWALLL.
OrthoDBiEOG7BZVWQ.
PhylomeDBiQ5BIV9.
TreeFamiTF330766.

Miscellaneous databases

GenomeRNAii503542.
PROiQ5BIV9.
SOURCEiSearch...

Gene expression databases

BgeeiQ5BIV9.
CleanExiHS_SPRN.
GenevisibleiQ5BIV9. HS.

Family and domain databases

InterProiIPR029238. Shadoo.
[Graphical view]
PfamiPF14999. Shadoo. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Shadoo, a new protein highly conserved from fish to mammals and with similarity to prion protein."
    Premzl M., Sangiorgio L., Strumbo B., Marshall Graves J.A., Simonic T., Gready J.E.
    Gene 314:89-102(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
  3. "Evolution of vertebrate genes related to prion and Shadoo proteins-Clues from comparative genomic analysis."
    Premzl M., Gready J.E., Jermiin L.S., Simonic T., Marshall Graves J.A.
    Mol. Biol. Evol. 21:2210-2231(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHYLOGENY.
  4. "Comparative genomic analysis of prion genes."
    Premzl M., Gamulin V.
    BMC Genomics 8:1-1(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHYLOGENY.

Entry informationi

Entry nameiSPRN_HUMAN
AccessioniPrimary (citable) accession number: Q5BIV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: April 12, 2005
Last modified: July 6, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

'Shadoo' means 'shadow' in Japanese.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.