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Protein

Serpin B8

Gene

SERPINB8

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Has an important role in epithelial desmosome-mediated cell-cell adhesion.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei339 – 340Reactive bondBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.013.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin B8
Gene namesi
Name:SERPINB8
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 24

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000941101 – 374Serpin B8Add BLAST374

Proteomic databases

PaxDbiQ5BIR5.
PeptideAtlasiQ5BIR5.
PRIDEiQ5BIR5.

Expressioni

Gene expression databases

BgeeiENSBTAG00000001207.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001597.

Structurei

3D structure databases

ProteinModelPortaliQ5BIR5.
SMRiQ5BIR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00760000118789.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiQ5BIR5.
KOiK13965.
OMAiVVRNSRC.
OrthoDBiEOG091G0ION.
TreeFamiTF352619.

Family and domain databases

InterProiView protein in InterPro
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiView protein in Pfam
PF00079. Serpin. 1 hit.
SMARTiView protein in SMART
SM00093. SERPIN. 1 hit.
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiView protein in PROSITE
PS00284. SERPIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5BIR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDALCEANGT FAINLLKMLG EEDHLRNVFF SPLSLSSVLT MVLMGAKGNT
60 70 80 90 100
AAQMSQALCL NESGDVHRGF QSLLREVSTS GPKCLLRTAN RLFGEKTCDF
110 120 130 140 150
LPAFKESCQK FYQADLEELS FAEDTEECRK HINDWVMEKT DGKISEILGA
160 170 180 190 200
GTVSPLTKLV LVNAIYFKGK WNEQFDRKHT RGMPFKTNQE KKTVQMMFKQ
210 220 230 240 250
AKFKMGHVEE VPAQVLELPY VGAELSMLIL LPDENTDLAV VEKALTYEKF
260 270 280 290 300
RTWTSPEKLT EEKVQVFLPR LKLEASYDLE AFLRSLGMTD AFEEAKADFS
310 320 330 340 350
GMSAKKNVPM SKVAHKCFVE VNEEGTEAAG ATAVVRNSRC CRMEPKFCAD
360 370
HPFLFFIRHR ETNSILFCGR FSSP
Length:374
Mass (Da):42,173
Last modified:April 12, 2005 - v1
Checksum:i156506FF9023092E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021159 mRNA. Translation: AAX31341.1.
RefSeqiNP_001030364.1. NM_001035287.1.
XP_015315533.1. XM_015460047.1.
UniGeneiBt.20432.

Genome annotation databases

EnsembliENSBTAT00000001597; ENSBTAP00000001597; ENSBTAG00000001207.
GeneIDi513825.
KEGGibta:513825.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSPB8_BOVIN
AccessioniPrimary (citable) accession number: Q5BIR5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: April 12, 2005
Last modified: June 7, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families