Reviewed,
UniProtKB/Swiss-Prot Q5BIP9 (DUS18_BOVIN)
Last modified
January 19, 2010.
Version 35.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Dual specificity protein phosphatase 18 EC=3.1.3.48 EC=3.1.3.16 | ||
| Gene names |
| ||
| Organism | Bos taurus (Bovine) | ||
| Taxonomic identifier | 9913 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Protein attributes
| Sequence length | 188 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine By similarity. |
| Catalytic activity | Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphoprotein + H2O = a protein + phosphate. |
| Subcellular location | |
| Sequence similarities | Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 tyrosine-protein phosphatase domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm Nucleus |
| Molecular function | Hydrolase Protein phosphatase |
| Gene Ontology (GO) | |
| Biological process | protein amino acid dephosphorylation Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleusInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | MAP kinase tyrosine/serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro protein tyrosine phosphatase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 188 | 188 | Dual specificity protein phosphatase 18 | PRO_0000094827 | |||||
Regions | |||||||||
| Domain | 80 – 149 | 70 | Tyrosine-protein phosphatase | ||||||
Sites | |||||||||
| Active site | 104 | 1 | Phosphocysteine intermediate By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 31 | 1 | S → R in AAI10014. Ref.2 | ||||||
Sequences
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References
| [1] | "Characterization of 954 bovine full-CDS cDNA sequences." Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L. BMC Genomics 6:166-166(2005) [PubMed: 16305752] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [2] | NIH - Mammalian Gene Collection (MGC) project Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Liver. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BT021175 mRNA. Translation: AAX31357.1. BC110013 mRNA. Translation: AAI10014.1. |
| IPI | IPI00716808. |
| RefSeq | NP_001029431.1. |
| UniGene | Bt.37370 |
3D structure databases | |
| SMR | Q5BIP9. Positions 18-179. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSBTAT00000023205; ENSBTAP00000023205; ENSBTAG00000017459; Bos taurus. [Genome view] |
| GeneID | 505912. |
| KEGG | bta:505912. |
Organism-specific databases | |
| CTD | 505912. |
Phylogenomic databases | |
| eggNOG | maNOG07361. |
| HOVERGEN | Q5BIP9. |
| InParanoid | Q5BIP9. |
| OMA | MGVIPDI. |
| OrthoDB | EOG90043R. |
| PhylomeDB | Q5BIP9. |
Enzyme and pathway databases | |
| BRENDA | 3.1.3.16. 251. 3.1.3.48. 251. |
Family and domain databases | |
| InterPro | IPR000387. Dual-sp/Tyr_phosphatase. IPR020417. Dual-sp_phosphatase. IPR000340. Dual-sp_phosphatase_cat-dom. IPR020420. Dual-sp_phosphatase_famB. IPR020422. Dual-sp_phosphatase_subgr_cat. IPR016130. Tyr_Pase_AS. [Graphical view] |
| Pfam | PF00782. DSPc. 1 hit. [Graphical view] |
| PRINTS | PR01908. ADSPHPHTASE. PR01910. ADSPHPHTASEB. |
| SMART | SM00195. DSPc. 1 hit. [Graphical view] |
| PROSITE | PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DUS18_BOVIN | ||||||||
| Accession | Primary (citable) accession number: Q5BIP9 Secondary accession number(s): Q32KN1 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

Clusters with


