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Q5BIP9

- DUS18_BOVIN

UniProt

Q5BIP9 - DUS18_BOVIN

Protein

Dual specificity protein phosphatase 18

Gene

DUSP18

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (12 Apr 2005)
      Previous versions | rss
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    Functioni

    Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei104 – 1041Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. MAP kinase tyrosine/serine/threonine phosphatase activity Source: InterPro
    2. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
    3. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. peptidyl-tyrosine dephosphorylation Source: RefGenome

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity protein phosphatase 18 (EC:3.1.3.16, EC:3.1.3.48)
    Gene namesi
    Name:DUSP18
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 17

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity. Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Intermembrane side By similarity
    Note: Translocates to cytoplasm in response to apoptotic stimuli such as staurosporine treatment.By similarity

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Membrane, Mitochondrion, Mitochondrion inner membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 188188Dual specificity protein phosphatase 18PRO_0000094827Add
    BLAST

    Proteomic databases

    PRIDEiQ5BIP9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5BIP9.
    SMRiQ5BIP9. Positions 18-179.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini80 – 14970Tyrosine-protein phosphataseAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni95 – 14147Sufficient for mitochondrial localizationBy similarityAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2453.
    GeneTreeiENSGT00750000117525.
    HOGENOMiHOG000233766.
    HOVERGENiHBG051422.
    InParanoidiQ5BIP9.
    KOiK14165.
    OMAiASPCAFP.
    OrthoDBiEOG7PK90H.
    TreeFamiTF316009.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR020417. Atypical_DUSP.
    IPR020420. Atypical_DUSP_famB.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    [Graphical view]
    PRINTSiPR01908. ADSPHPHTASE.
    PR01910. ADSPHPHTASEB.
    SMARTiSM00195. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5BIP9-1 [UniParc]FASTAAdd to Basket

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    MTASPCAFPV QFRQPSVSGL SQITSSLYIS SGVAANNRLM LSSNRISTVI    50
    NVSVEVVNAL YEDIHYVQVP VADTPTSRLC DFFDPIADHI HSVEMKQGRT 100
    LLHCAAGVSR SAALCLAYLM KYHAMSLLDA HTWTKSCRPI IRPNNGFWEQ 150
    LIHYEFQLFG RNTVHMVSSP VGMIPDIYEK EVRQMIPL 188
    Length:188
    Mass (Da):21,028
    Last modified:April 12, 2005 - v1
    Checksum:i3EADB96A25E1CE6B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti31 – 311S → R in AAI10014. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT021175 mRNA. Translation: AAX31357.1.
    BC110013 mRNA. Translation: AAI10014.1.
    RefSeqiNP_001029431.1. NM_001034259.1.
    UniGeneiBt.37370.

    Genome annotation databases

    EnsembliENSBTAT00000023205; ENSBTAP00000023205; ENSBTAG00000017459.
    GeneIDi505912.
    KEGGibta:505912.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT021175 mRNA. Translation: AAX31357.1 .
    BC110013 mRNA. Translation: AAI10014.1 .
    RefSeqi NP_001029431.1. NM_001034259.1.
    UniGenei Bt.37370.

    3D structure databases

    ProteinModelPortali Q5BIP9.
    SMRi Q5BIP9. Positions 18-179.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q5BIP9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000023205 ; ENSBTAP00000023205 ; ENSBTAG00000017459 .
    GeneIDi 505912.
    KEGGi bta:505912.

    Organism-specific databases

    CTDi 150290.

    Phylogenomic databases

    eggNOGi COG2453.
    GeneTreei ENSGT00750000117525.
    HOGENOMi HOG000233766.
    HOVERGENi HBG051422.
    InParanoidi Q5BIP9.
    KOi K14165.
    OMAi ASPCAFP.
    OrthoDBi EOG7PK90H.
    TreeFami TF316009.

    Miscellaneous databases

    NextBioi 20867370.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR020417. Atypical_DUSP.
    IPR020420. Atypical_DUSP_famB.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    [Graphical view ]
    PRINTSi PR01908. ADSPHPHTASE.
    PR01910. ADSPHPHTASEB.
    SMARTi SM00195. DSPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Liver.

    Entry informationi

    Entry nameiDUS18_BOVIN
    AccessioniPrimary (citable) accession number: Q5BIP9
    Secondary accession number(s): Q32KN1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2005
    Last sequence update: April 12, 2005
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3