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Protein

Protrudin

Gene

ZFYVE27

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport. Promotes axonal elongation and contributes to the establishment of neuronal cell polarity. Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner. Contributes to both the formation and stabilization of the tubular ER network. Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections. Acts as an adapter protein that facilitates the interaction of KIF5A with VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 and the ZFYVE27-KIF5A complex contributes to the transport of these proteins in neurons. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a KIF5A/B-dependent manner.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri337 – 403FYVE-typePROSITE-ProRule annotationAdd BLAST67

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protrudin
Alternative name(s):
Zinc finger FYVE domain-containing protein 27
Gene namesi
Name:ZFYVE27
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 26

Organism-specific databases

VGNCiVGNC:37177 ZFYVE27

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 66CytoplasmicBy similarityAdd BLAST66
Transmembranei67 – 87HelicalSequence analysisAdd BLAST21
Topological domaini88LumenalBy similarity1
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Topological domaini110 – 187CytoplasmicBy similarityAdd BLAST78
Intramembranei188 – 208HelicalSequence analysisAdd BLAST21
Topological domaini209 – 404CytoplasmicBy similarityAdd BLAST196

Keywords - Cellular componenti

Cell membrane, Cell projection, Endoplasmic reticulum, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002456001 – 404ProtrudinAdd BLAST404

Post-translational modificationi

Phosphorylated. Phosphorylation is induced by NGF through the MAPK/ERK pathway and modulates interaction with RAB11A (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5BIM5
PRIDEiQ5BIM5

Expressioni

Gene expression databases

BgeeiENSBTAG00000018564

Interactioni

Subunit structurei

Can form homooligomers (monomers, dimers and tetramers). Interacts with RAB11A (GDP-bound form); regulates RAB11A. Interacts with FKBP8; may negatively regulate ZFYVE27 phosphorylation. Interacts with VAPA (via MSP domain); may regulate ZFYVE27 retention in the endoplasmic reticulum and its function in cell projections formation. Interacts with VAPB (via MSP domain). Interacts with RAB11B (GDP-bound form), REEP1, REEP5, ATL1, ATL2, ATL3, SPAST, SURF4, KIF5A, KIF5B, KIF5C and RTN3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024705

Structurei

3D structure databases

ProteinModelPortaliQ5BIM5
SMRiQ5BIM5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 205Sufficient for localization to endoplasmic reticulum tubular network and for interactions with REEP1, REEP5, ATL1, ATL2, ATL3 and SPASTBy similarityAdd BLAST205
Regioni1 – 92Sufficient for homooligomerizationBy similarityAdd BLAST92
Regioni51 – 64Necessary for interaction with RAB11A and function in neurite outgrowthBy similarityAdd BLAST14
Regioni271 – 354Necessary for interaction with KIF5ABy similarityAdd BLAST84
Regioni286 – 292Necessary for interaction with VAPABy similarity7

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri337 – 403FYVE-typePROSITE-ProRule annotationAdd BLAST67

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IJBT Eukaryota
ENOG4111KCR LUCA
GeneTreeiENSGT00390000013298
HOGENOMiHOG000155785
HOVERGENiHBG054907
InParanoidiQ5BIM5
KOiK19368
OMAiRCCSFKV
OrthoDBiEOG091G0QCA
TreeFamiTF331044

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01363 FYVE, 1 hit
SMARTiView protein in SMART
SM00064 FYVE, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50178 ZF_FYVE, 1 hit

Sequencei

Sequence statusi: Complete.

Q5BIM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTSEREGCG PEVSPSTVPE ATLESLPVPT KLPAFDLFNL VLSYKRLEVY
60 70 80 90 100
LEPLKDAGDG VRYLLRWQTP LCSLLTCLGL NVLFLTLNEG AWYSVGALMI
110 120 130 140 150
SVPALLGYLQ EGCQARLSES ELMRRKYHSV RQEDLQRVRL SRPEAVAEVK
160 170 180 190 200
SFLIQLEALL SRLCGTCEAA YRVLHWENPA VSSQFYGALL GTVCMLYLLP
210 220 230 240 250
LCWVLALLNS TLFLGNVEFF RVVSEYRASL QRRMNPKQEE SAFESPPPSD
260 270 280 290 300
AGGKGALVDC TPAPTPTEDL TPGSVEEAEE AEPDEEFKDA IEEDDEGAPC
310 320 330 340 350
PAEDELVLQD NGFLSKNEVL RSKVSRLTER LRKRYPTNNY GSCTGCSATF
360 370 380 390 400
SVLKKRRNCS NCGNIFCSRC CSFKVPRSSM GATAPEAQRE TVFVCASCNQ

TLSK
Length:404
Mass (Da):44,777
Last modified:April 12, 2005 - v1
Checksum:iE03B5E78B1033F88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021199 mRNA Translation: AAX31381.1
BC134516 mRNA Translation: AAI34517.1
RefSeqiNP_001017939.1, NM_001017939.1
UniGeneiBt.54620

Genome annotation databases

EnsembliENSBTAT00000024705; ENSBTAP00000024705; ENSBTAG00000018564
GeneIDi514383
KEGGibta:514383

Similar proteinsi

Entry informationi

Entry nameiZFY27_BOVIN
AccessioniPrimary (citable) accession number: Q5BIM5
Secondary accession number(s): A4IFC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: April 12, 2005
Last modified: April 25, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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