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Protein

Serine/threonine-protein kinase tel1

Gene

tel1

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

DNA damage

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase tel1 (EC:2.7.11.1)
Alternative name(s):
ATM homolog
DNA-damage checkpoint kinase tel1
Telomere length regulation protein 1
Gene namesi
Name:tel1
ORF Names:AN0038
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome VIII
  • UP000005890 Componenti: Partially assembled WGS sequence

Subcellular locationi

  • Nucleus By similarity
  • Chromosometelomere By similarity

  • Note: Localizes to nuclear DNA repair foci with other DNA repair proteins in response to DNA double strand breaks.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 27932793Serine/threonine-protein kinase tel1PRO_0000227702Add
BLAST

Interactioni

Subunit structurei

Associates with DNA double-strand breaks.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5BHE2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1734 – 2334601FATPROSITE-ProRule annotationAdd
BLAST
Domaini2464 – 2793330PI3K/PI4KPROSITE-ProRule annotationAdd
BLAST
Domaini2761 – 279333FATCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family. ATM subfamily.Curated
Contains 1 FAT domain.PROSITE-ProRule annotation
Contains 1 FATC domain.PROSITE-ProRule annotation
Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000176680.
InParanoidiQ5BHE2.
KOiK04728.
OMAiANVLWDQ.
OrthoDBiEOG7ZWD92.

Family and domain databases

Gene3Di1.10.1070.11. 3 hits.
InterProiIPR016024. ARM-type_fold.
IPR015519. ATM/Tel1.
IPR003152. FATC_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR014009. PIK_FAT.
IPR021668. TAN.
[Graphical view]
PANTHERiPTHR11139:SF72. PTHR11139:SF72. 5 hits.
PfamiPF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF11640. TAN. 1 hit.
[Graphical view]
SMARTiSM01343. FATC. 1 hit.
SM00146. PI3Kc. 1 hit.
SM01342. TAN. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 5 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5BHE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGEITLDGA IALLSSDKTK DRTDGLADLK HILQKNKRNS NLQSMSDKAC
60 70 80 90 100
HKIFESLFRL VSTEKTFYNR ANSKGASSSK AAATRLSACA SVVRTAVETF
110 120 130 140 150
LRNLRIKSVR AILDHITNVL VSPDSSLFEL LSVDYTKCLS TILHYPPHVE
160 170 180 190 200
HLGVEEWESV LKFCLKVVNV RNDHNSQQST WSPHSSVMDD YIGASGGRST
210 220 230 240 250
PSRMTPSLAV REKPKGPTGV VEEALSCIKI LSGVPNAPLQ DNAESILLGL
260 270 280 290 300
ASYVGSPSLS GSGHQTAFSA INAVAMGIIF DNSELVRVTL LDLVPVIRQH
310 320 330 340 350
WTTKLMGLKD ELLVTTMLIV TFLIDEIRRK PDEALIAVID GLIHTLQREY
360 370 380 390 400
FRRSEKDILQ VDELVFDTNS IGQHEKFRLW PRLESPRSEH NWTVVWIMAR
410 420 430 440 450
LLELSEELTT RLSTHCPPEA ETPSKRQRIS SKIDDVFRDS TASFGIRRVC
460 470 480 490 500
ALQLIPFLLN HYACIDSKVS LLERLIPNIN DDNATISSWT MIAIACIAAS
510 520 530 540 550
PQADKPPLKR YWQQAWDLTS RASTSQLTSR AACYLQNSIL QYSLLDYAAV
560 570 580 590 600
AETINSMLSF VRLNGPSTVS DASLELWASV IRMTAQINPG SVSNASVQIC
610 620 630 640 650
ELVDIYDIWD AETTVSIQKS SQSDPNDLGI LDLLQAKSES FLHTWQSLSE
660 670 680 690 700
DKSRHVTPDI VQILTSFCIT VALYTSCLPE QPGPRLQTLL SNSRPTAIHR
710 720 730 740 750
ALYGLLTPLS EVLESQRQSH KQRLYALNDD TMDLDDPFGP STDQVEEASN
760 770 780 790 800
ILCTNRSDLP LFQDSASFHR YMTILISIYN RMYSQQSEPQ QHVTRALEDY
810 820 830 840 850
LNDLDEVDLL AAHDLLPYVY QSCARTDRQT QLVLLENLGE KCLQTYELER
860 870 880 890 900
CENSHLLCIQ MMCSLAMSWT RGTQDSLSDS AADIYTWFTT IFLKKGRASS
910 920 930 940 950
SVLIAFAKLL GVILSLNPAY SSDQSSPSPK TTLFKIISDG EVLVKFNAGS
960 970 980 990 1000
LVPQLFGQFL LEDHDNVFND VLECLPRDPT WEEGIAVRLF LLAQLASKWH
1010 1020 1030 1040 1050
TLLRRSIYHI FETPAQVHHS LWYAEKCLRS VSDALGLQDA KEIFRLFSSQ
1060 1070 1080 1090 1100
ILYTWTETQS IKSMPFSIFG YANLNDMICD AQDEIVGQIM MRASESDAAE
1110 1120 1130 1140 1150
LSEILGRPFV GLLTDSFYKA EAYTIAHDIS TPPREGSQPK GVENRLKKIL
1160 1170 1180 1190 1200
GAEVFVTLIE AQFPQIVATF FGSLDFFQQV EKAFSKRESF QEALVTLKRI
1210 1220 1230 1240 1250
TEKGAARTVL PPNQQPSFRA RYLLDELEFL CKRSGYELET IWTPTLASYV
1260 1270 1280 1290 1300
CRTLLESIHP ALGSLHACSV LRKIKILICV AGPVMLSDYP FEMIIHGLQP
1310 1320 1330 1340 1350
FLVDISCSED AVAIFWYLLE AGKTYLCEQP GLMAGIAVST SLSLGRFLAS
1360 1370 1380 1390 1400
PPVNSRQESQ LQAVVGNLRT FCRWFDGYLR SYTSPALDDE SSRSFRRFTC
1410 1420 1430 1440 1450
SLQTIVEQES SGSGANETDL LLEVLKDRES KSGLLSKPIS DRVISLLCST
1460 1470 1480 1490 1500
SKAALGYHLT TIERDEDAIL NAVTVCQTLR DFNPGTEYRS WAARVIGRAF
1510 1520 1530 1540 1550
AATGKISDAL LREQDLTLFR SSSTQSGTDI LCRSKANILE VLGSKLLNSR
1560 1570 1580 1590 1600
QTGPIERTLQ LIISNLANFP DFEPCVSAIS PSVMKALTWS PYQCPGISLN
1610 1620 1630 1640 1650
ALEAKELENV HGWDLSLSPS YWARNVGLFL SKAAAEDPVI GSLSNILYLI
1660 1670 1680 1690 1700
PDLAVQLLPY ILHDALLAEI RGKVAEVRDS ISQIFNETLR AGAENSIPHA
1710 1720 1730 1740 1750
RLIIKCVLYL RNQPKPGEET IVDRDDWLDI NYAVASSAAS RCRLPKTALM
1760 1770 1780 1790 1800
FLETHVSRCT ASSRRSSVAK YDLPAGLLHD IFKNIDDPDF FYGVQQTSSL
1810 1820 1830 1840 1850
DSVIETLEHE SSGFKNLLFQ SAQYDSEIQM TGSGNAYGVL KALNSTNLQG
1860 1870 1880 1890 1900
IANSMIGALG NSSDTAVPLG SMLKAATNLR QWEIPISPLN TSPPATIFRA
1910 1920 1930 1940 1950
FQALNTPGPL VDMRASIGES YRSNLNLINS DRRSATSLRT AMRTLGILTE
1960 1970 1980 1990 2000
IEEVLGSGSA AEIDQKWEEI SARTSWLKNT DVQEVGEILS SHETLFSSIK
2010 2020 2030 2040 2050
QKDYLRSAFN LSDIDAQLLE VKVIRQSLHI ARNHGIAQAS LRSAVYLSKL
2060 2070 2080 2090 2100
ANHSVSLGLN IEGVAKFDLA NVLWDQGEMA PSIQILQQLK DRNDLHKQAI
2110 2120 2130 2140 2150
PISRAELLVT LSQGHHIAEA RLEKPEAIIQ NYLTPAVKEL KGRSEGEDAG
2160 2170 2180 2190 2200
RVYHGFAIFC DQQLQNPDGL EDFARIEQLR NRKEKEVVAL DAMLKTAEGK
2210 2220 2230 2240 2250
ERDNLKFHRT KTKQWFDLDD REYQRLKRSR EAFLQQCLEN YLICLRESEA
2260 2270 2280 2290 2300
YNNDVLRFCA LWLAQSHSDI ANSAVSKYIA GVPSRKFAPL MNQLTSRLLD
2310 2320 2330 2340 2350
VSDDFQALLS ELIYRICSDH PFHGMYQIFA SSKSKGGRDQ SALSRNRAAA
2360 2370 2380 2390 2400
KLADIMRNDR HIGPLWVAVH NTNINYVRFA VERLDDKAKS GAKIRLNKLA
2410 2420 2430 2440 2450
PGIRLEQDAV NQRLPPPTMK IDIRVDCDYS DVPKLAKYLP DFTVASGVSA
2460 2470 2480 2490 2500
PKIVTAIASN GVRYKQLFKG GNDDLRQDAI MEQVFEQVSS LLKDHQATRQ
2510 2520 2530 2540 2550
RNLGIRAYKV LPLTSNAGII EFVPNTIPLN DFLMPAHQRY YPRDMKPSAC
2560 2570 2580 2590 2600
RKHIADVQTR SFEQRVRTYR QVIEKFHPVM RYFFMEKFNN PDDWFGRRLS
2610 2620 2630 2640 2650
YTQSTAAISI LGHVLGLGDR HGHNILLDER TGEVVHIDLG VAFEQGRVLP
2660 2670 2680 2690 2700
VPEVVPFRLT RDLVDGMGIT KTEGVFRRCC EFTLEALRQE SYSIMTILDV
2710 2720 2730 2740 2750
LRYDPLYSWT VSPLRMKKMQ EQDTSDGPPV LPGSTTDQQR PTNEPSEADR
2760 2770 2780 2790
ALTVVAKKLS KTLSVTATVN ELIQQATDEK NLAVLYCGWA AYA
Length:2,793
Mass (Da):312,284
Last modified:April 26, 2005 - v1
Checksum:i4CE89A90D235FF36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000002 Genomic DNA. Translation: EAA65357.1.
BN001308 Genomic DNA. Translation: CBF90326.1.
RefSeqiXP_657642.1. XM_652550.1.

Genome annotation databases

EnsemblFungiiCADANIAT00002718; CADANIAP00002718; CADANIAG00002718.
EAA65357; EAA65357; AN0038.2.
GeneIDi2875815.
KEGGiani:AN0038.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000002 Genomic DNA. Translation: EAA65357.1.
BN001308 Genomic DNA. Translation: CBF90326.1.
RefSeqiXP_657642.1. XM_652550.1.

3D structure databases

ProteinModelPortaliQ5BHE2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADANIAT00002718; CADANIAP00002718; CADANIAG00002718.
EAA65357; EAA65357; AN0038.2.
GeneIDi2875815.
KEGGiani:AN0038.2.

Phylogenomic databases

HOGENOMiHOG000176680.
InParanoidiQ5BHE2.
KOiK04728.
OMAiANVLWDQ.
OrthoDBiEOG7ZWD92.

Family and domain databases

Gene3Di1.10.1070.11. 3 hits.
InterProiIPR016024. ARM-type_fold.
IPR015519. ATM/Tel1.
IPR003152. FATC_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR014009. PIK_FAT.
IPR021668. TAN.
[Graphical view]
PANTHERiPTHR11139:SF72. PTHR11139:SF72. 5 hits.
PfamiPF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF11640. TAN. 1 hit.
[Graphical view]
SMARTiSM01343. FATC. 1 hit.
SM00146. PI3Kc. 1 hit.
SM01342. TAN. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 5 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiATM_EMENI
AccessioniPrimary (citable) accession number: Q5BHE2
Secondary accession number(s): C8VRE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: April 26, 2005
Last modified: May 11, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.