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Q5BH83

- DNLI4_EMENI

UniProt

Q5BH83 - DNLI4_EMENI

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Protein

DNA ligase 4

Gene

lig4

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Involved in ds DNA break repair. Has a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologus end-joining By similarity.By similarity

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).PROSITE-ProRule annotation

Cofactori

Magnesium.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei315 – 3151ATPBy similarity
Active sitei317 – 3171N6-AMP-lysine intermediatePROSITE-ProRule annotation
Binding sitei322 – 3221ATPBy similarity
Binding sitei344 – 3441ATPBy similarity
Metal bindingi384 – 3841Magnesium 1Sequence Analysis
Metal bindingi484 – 4841Magnesium 2Sequence Analysis
Binding sitei489 – 4891ATPBy similarity
Binding sitei500 – 5001ATPBy similarity
Binding sitei506 – 5061ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: RefGenome
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation Source: RefGenome
  3. DNA ligation involved in DNA repair Source: InterPro
  4. DNA recombination Source: UniProtKB-KW
  5. double-strand break repair via nonhomologous end joining Source: RefGenome
  6. lagging strand elongation Source: RefGenome
  7. nucleotide-excision repair Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligase 4 (EC:6.5.1.1)
Alternative name(s):
DNA ligase IV
Polydeoxyribonucleotide synthase [ATP] 4
Gene namesi
Name:lig4
ORF Names:AN0097
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome VIII

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. chromosome Source: RefGenome
  2. DNA ligase IV complex Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10091009DNA ligase 4PRO_0000278382Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00002653.

Structurei

3D structure databases

ProteinModelPortaliQ5BH83.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini715 – 80894BRCT 1PROSITE-ProRule annotationAdd
BLAST
Domaini887 – 995109BRCT 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.Curated
Contains 2 BRCT domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000176213.
InParanoidiQ5BH83.
KOiK10777.
OMAiHMCPSTK.
OrthoDBiEOG7QC84G.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
3.40.50.10190. 2 hits.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR029710. LIG4.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PANTHERiPTHR10459:SF7. PTHR10459:SF7. 1 hit.
PfamiPF00533. BRCT. 1 hit.
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 2 hits.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 2 hits.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 2 hits.
PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5BH83-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
METDQDMHDQ AMAGEETDLD EKYPNRPQNK APTLPFHDLY ETLFRPLREI
60 70 80 90 100
KKKPVGPAGN RRKAGPHGLS AANLNPIERR RDIIERFISR WRKEVGDDIY
110 120 130 140 150
PAFRLILPDK DRDRAMYGMK EKIIGKMLVN IMKIDKNSED GFNLLNWKLP
160 170 180 190 200
GQSATSSMAG DFAGRCYDVV SKRPMRTEFG NMLIEEVNEK LDQLSSASKE
210 220 230 240 250
EEQLPILAEF YRRMNPEELA WLIRIILRQM KLGATERTFF DVWHPDAENL
260 270 280 290 300
YSISSSLRRV CWELHDPNIR LDAEDRGVSL MQCFQPQLAQ FQMQSLDRMI
310 320 330 340 350
ARMRPTEDDP VFWIEEKLDG ERMQLHMVSD ASAPGGRRFR FWSRKAKDYT
360 370 380 390 400
YLYGNGIYDE AGSLTRHLKD AFADGVDNLI LDGEMITWNT EQDAPEPFGT
410 420 430 440 450
LKTAALSEQR NPFRQGIHPL FRVFDILYLN GRDLTRYTLR DRRNALQKVI
460 470 480 490 500
KPVHRRFEVH SYEEATTKAE VEASLRKAVA EASEGLVLKN PRSPYRLNER
510 520 530 540 550
HDDWMKVKPE YMTEFGESLD LVVIGGYYGS GHRGGKLSSF LCGLRVDEGQ
560 570 580 590 600
SSQGSNPTKC YSFCKVGGGF TAADYANIRH HTDGKWVEWN PKKPPTTYIE
610 620 630 640 650
LAGGDSQYER PDMWIKPEDS VVICVKAASV SVSDQFRIGL TLRFPRFKRL
660 670 680 690 700
RMDKDWKSAL SVQEFLDLKS HAEQEHREKE FNVENFRKKR VKKTTKKPLA
710 720 730 740 750
IAGYDENAEV QYAGPSGHIF DGLNFFILTD SNAPVKKSKA ELENLVKANG
760 770 780 790 800
GRIFQTNDAV PDTICIADRR TVKAASLQKK GDIDIIRPSW ILDCIKQSEI
810 820 830 840 850
DAGLPDLLLP LEPGHMFFMT KDKEEIVAGS LDQFNDSYAR DITVEELRNL
860 870 880 890 900
LDQMAKDGKT DSFCSPEAIQ KVTEHIQEKV DSGWTMPCGW LFKGLVLCFP
910 920 930 940 950
ENENDSASEG PEPKQSQRIH LAQNTAKFAG ASVTTSLKDT SITHVVVDPD
960 970 980 990 1000
FTSSELPKLR RTLSTRRKLP HIVKVNWIED SWKENTLLDE EQHMPVYMRR

YPNIQLMKV
Length:1,009
Mass (Da):115,689
Last modified:April 26, 2005 - v1
Checksum:i60055FF8D2E80557
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACD01000003 Genomic DNA. Translation: EAA65275.1.
BN001308 Genomic DNA. Translation: CBF90206.1.
RefSeqiXP_657701.1. XM_652609.1.

Genome annotation databases

EnsemblFungiiCADANIAT00002653; CADANIAP00002653; CADANIAG00002653.
GeneIDi2875873.
KEGGiani:AN0097.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACD01000003 Genomic DNA. Translation: EAA65275.1 .
BN001308 Genomic DNA. Translation: CBF90206.1 .
RefSeqi XP_657701.1. XM_652609.1.

3D structure databases

ProteinModelPortali Q5BH83.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 162425.CADANIAP00002653.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00002653 ; CADANIAP00002653 ; CADANIAG00002653 .
GeneIDi 2875873.
KEGGi ani:AN0097.2.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000176213.
InParanoidi Q5BH83.
KOi K10777.
OMAi HMCPSTK.
OrthoDBi EOG7QC84G.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
3.40.50.10190. 2 hits.
InterProi IPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR029710. LIG4.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
PANTHERi PTHR10459:SF7. PTHR10459:SF7. 1 hit.
Pfami PF00533. BRCT. 1 hit.
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SMARTi SM00292. BRCT. 2 hits.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 2 hits.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS50172. BRCT. 2 hits.
PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiDNLI4_EMENI
AccessioniPrimary (citable) accession number: Q5BH83
Secondary accession number(s): C8VQN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: April 26, 2005
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3