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Q5BH83

- DNLI4_EMENI

UniProt

Q5BH83 - DNLI4_EMENI

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Protein
DNA ligase 4
Gene
lig4, AN0097
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Involved in ds DNA break repair. Has a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologus end-joining By similarity.

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

Cofactori

Magnesium By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei315 – 3151ATP By similarity
Active sitei317 – 3171N6-AMP-lysine intermediate By similarity
Binding sitei322 – 3221ATP By similarity
Binding sitei344 – 3441ATP By similarity
Metal bindingi384 – 3841Magnesium 1 Reviewed prediction
Metal bindingi484 – 4841Magnesium 2 Reviewed prediction
Binding sitei489 – 4891ATP By similarity
Binding sitei500 – 5001ATP By similarity
Binding sitei506 – 5061ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: RefGenome
  4. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. DNA ligation Source: RefGenome
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. double-strand break repair via nonhomologous end joining Source: RefGenome
  5. lagging strand elongation Source: RefGenome
  6. nucleotide-excision repair Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligase 4 (EC:6.5.1.1)
Alternative name(s):
DNA ligase IV
Polydeoxyribonucleotide synthase [ATP] 4
Gene namesi
Name:lig4
ORF Names:AN0097
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome VIII

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. DNA ligase IV complex Source: RefGenome
  2. chromosome Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10091009DNA ligase 4
PRO_0000278382Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00002653.

Structurei

3D structure databases

ProteinModelPortaliQ5BH83.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini715 – 80894BRCT 1
Add
BLAST
Domaini887 – 995109BRCT 2
Add
BLAST

Sequence similaritiesi

Contains 2 BRCT domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000176213.
KOiK10777.
OMAiHMCPSTK.
OrthoDBiEOG7QC84G.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
3.40.50.10190. 2 hits.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF00533. BRCT. 1 hit.
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 2 hits.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 2 hits.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 2 hits.
PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5BH83-1 [UniParc]FASTAAdd to Basket

« Hide

METDQDMHDQ AMAGEETDLD EKYPNRPQNK APTLPFHDLY ETLFRPLREI     50
KKKPVGPAGN RRKAGPHGLS AANLNPIERR RDIIERFISR WRKEVGDDIY 100
PAFRLILPDK DRDRAMYGMK EKIIGKMLVN IMKIDKNSED GFNLLNWKLP 150
GQSATSSMAG DFAGRCYDVV SKRPMRTEFG NMLIEEVNEK LDQLSSASKE 200
EEQLPILAEF YRRMNPEELA WLIRIILRQM KLGATERTFF DVWHPDAENL 250
YSISSSLRRV CWELHDPNIR LDAEDRGVSL MQCFQPQLAQ FQMQSLDRMI 300
ARMRPTEDDP VFWIEEKLDG ERMQLHMVSD ASAPGGRRFR FWSRKAKDYT 350
YLYGNGIYDE AGSLTRHLKD AFADGVDNLI LDGEMITWNT EQDAPEPFGT 400
LKTAALSEQR NPFRQGIHPL FRVFDILYLN GRDLTRYTLR DRRNALQKVI 450
KPVHRRFEVH SYEEATTKAE VEASLRKAVA EASEGLVLKN PRSPYRLNER 500
HDDWMKVKPE YMTEFGESLD LVVIGGYYGS GHRGGKLSSF LCGLRVDEGQ 550
SSQGSNPTKC YSFCKVGGGF TAADYANIRH HTDGKWVEWN PKKPPTTYIE 600
LAGGDSQYER PDMWIKPEDS VVICVKAASV SVSDQFRIGL TLRFPRFKRL 650
RMDKDWKSAL SVQEFLDLKS HAEQEHREKE FNVENFRKKR VKKTTKKPLA 700
IAGYDENAEV QYAGPSGHIF DGLNFFILTD SNAPVKKSKA ELENLVKANG 750
GRIFQTNDAV PDTICIADRR TVKAASLQKK GDIDIIRPSW ILDCIKQSEI 800
DAGLPDLLLP LEPGHMFFMT KDKEEIVAGS LDQFNDSYAR DITVEELRNL 850
LDQMAKDGKT DSFCSPEAIQ KVTEHIQEKV DSGWTMPCGW LFKGLVLCFP 900
ENENDSASEG PEPKQSQRIH LAQNTAKFAG ASVTTSLKDT SITHVVVDPD 950
FTSSELPKLR RTLSTRRKLP HIVKVNWIED SWKENTLLDE EQHMPVYMRR 1000
YPNIQLMKV 1009
Length:1,009
Mass (Da):115,689
Last modified:April 26, 2005 - v1
Checksum:i60055FF8D2E80557
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACD01000003 Genomic DNA. Translation: EAA65275.1.
BN001308 Genomic DNA. Translation: CBF90206.1.
RefSeqiXP_657701.1. XM_652609.1.

Genome annotation databases

EnsemblFungiiCADANIAT00002653; CADANIAP00002653; CADANIAG00002653.
GeneIDi2875873.
KEGGiani:AN0097.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACD01000003 Genomic DNA. Translation: EAA65275.1 .
BN001308 Genomic DNA. Translation: CBF90206.1 .
RefSeqi XP_657701.1. XM_652609.1.

3D structure databases

ProteinModelPortali Q5BH83.
ModBasei Search...

Protein-protein interaction databases

STRINGi 162425.CADANIAP00002653.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00002653 ; CADANIAP00002653 ; CADANIAG00002653 .
GeneIDi 2875873.
KEGGi ani:AN0097.2.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000176213.
KOi K10777.
OMAi HMCPSTK.
OrthoDBi EOG7QC84G.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
3.40.50.10190. 2 hits.
InterProi IPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF00533. BRCT. 1 hit.
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SMARTi SM00292. BRCT. 2 hits.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 2 hits.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS50172. BRCT. 2 hits.
PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiDNLI4_EMENI
AccessioniPrimary (citable) accession number: Q5BH83
Secondary accession number(s): C8VQN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: April 26, 2005
Last modified: April 16, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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