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Protein

Autophagy-related protein 18

Gene

atg18

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Autophagy, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 18
Gene namesi
Name:atg18
ORF Names:AN0127
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome VIII
  • UP000005890 Componenti: Partially assembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000508661 – 429Autophagy-related protein 18Add BLAST429

Interactioni

Subunit structurei

Component of the PI(3,5)P2 regulatory complex.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5BH53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1 – 36WD 1Add BLAST36
Repeati69 – 114WD 2Add BLAST46
Repeati139 – 182WD 3Add BLAST44
Repeati185 – 225WD 4Add BLAST41
Repeati230 – 269WD 5Add BLAST40
Repeati309 – 355WD 6Add BLAST47
Repeati367 – 407WD 7Add BLAST41

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi226 – 230FRRGT-motifBy similarity5

Domaini

The N-terminus might form a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane.By similarity
The FRRGT-motif is essential for the cytoplasm to vacuole transport (Cvt) pathway, for the recruitment of atg8 and atg16 to the PAS in nutrient-rich medium, and for its recruitment to and dissociation from the PAS under starvation conditions.By similarity

Sequence similaritiesi

Belongs to the WD repeat SVP1 family.Curated
Contains 7 WD repeats.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOGENOMiHOG000217543.
InParanoidiQ5BH53.
KOiK17908.
OMAiIRRTSQN.
OrthoDBiEOG092C3UKJ.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
SMARTiSM00320. WD40. 2 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.

Sequencei

Sequence statusi: Complete.

Q5BH53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMNFVTFNQ DYSYLAVATS KGFRIFTTDP FAKSYETKDG NIAIIEMLFS
60 70 80 90 100
TSLVALILSP RRLQITNTKR QSTICELTFP TTVLAVKLNR KRLVIVLEDQ
110 120 130 140 150
IYLYDIQTMK LLYTIETSPN PNALCALSPS SENCYLAYPL PQKAAPSSFN
160 170 180 190 200
PPAHAPPGNT HVSPTSGEVL IFDTLKLEAI NVIEAHRSPL ACITLNSDGT
210 220 230 240 250
LIATASDKGT IIRVFSVPDG HKLYQFRRGS IPSRIFSMSF NTTSTLLCVS
260 270 280 290 300
SSTETIHLFK LSQPSQLQET SSANTSSTGR RRSLSSLSQS PEREATEEDN
310 320 330 340 350
GSSDLASRKH NGTLMGMLRR TSQNVGGAFA AKVGGYLPKG VSEMWEPARD
360 370 380 390 400
FAWIKIPKPN QGQGPNANTG PLRSVVAMSS NTPQVMVVTS DGNFYVFSID
410 420
LSKGGEGTLT KQYSVLESND RLGYSVADY
Length:429
Mass (Da):46,877
Last modified:November 16, 2011 - v2
Checksum:i9ACB092403ABBF5C
GO

Sequence cautioni

The sequence EAA65305 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000004 Genomic DNA. Translation: EAA65305.1. Sequence problems.
BN001308 Genomic DNA. Translation: CBF90145.1.
RefSeqiXP_657731.1. XM_652639.1.

Genome annotation databases

EnsemblFungiiCADANIAT00002619; CADANIAP00002619; CADANIAG00002619.
EAA65305; EAA65305; AN0127.2.
GeneIDi2875905.
KEGGiani:AN0127.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000004 Genomic DNA. Translation: EAA65305.1. Sequence problems.
BN001308 Genomic DNA. Translation: CBF90145.1.
RefSeqiXP_657731.1. XM_652639.1.

3D structure databases

ProteinModelPortaliQ5BH53.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADANIAT00002619; CADANIAP00002619; CADANIAG00002619.
EAA65305; EAA65305; AN0127.2.
GeneIDi2875905.
KEGGiani:AN0127.2.

Phylogenomic databases

HOGENOMiHOG000217543.
InParanoidiQ5BH53.
KOiK17908.
OMAiIRRTSQN.
OrthoDBiEOG092C3UKJ.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
SMARTiSM00320. WD40. 2 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiATG18_EMENI
AccessioniPrimary (citable) accession number: Q5BH53
Secondary accession number(s): C8VQJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: November 16, 2011
Last modified: November 30, 2016
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.