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Q5BFG8

- BGLB_EMENI

UniProt

Q5BFG8 - BGLB_EMENI

Protein

Beta-glucosidase B

Gene

bglB

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.1 Publication

    Catalytic activityi

    Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

    pH dependencei

    Optimum pH is 5.5.1 Publication

    Temperature dependencei

    Optimum temperature is 52 degrees Celsius.1 Publication

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei230 – 2301By similarity

    GO - Molecular functioni

    1. beta-glucosidase activity Source: UniProtKB

    GO - Biological processi

    1. cellulose catabolic process Source: UniProtKB-UniPathway
    2. glucan catabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

    Enzyme and pathway databases

    UniPathwayiUPA00696.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-glucosidase B (EC:3.2.1.21)
    Alternative name(s):
    Beta-D-glucoside glucohydrolase B
    Cellobiase B
    Gentiobiase B
    Gene namesi
    Name:bglB
    ORF Names:AN0712
    OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
    Taxonomic identifieri227321 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000000560: Chromosome VIII

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 845845Beta-glucosidase BPRO_0000394102Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi235 – 2351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi591 – 5911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi612 – 6121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi794 – 7941N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ5BFG8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 3 family.Curated

    Phylogenomic databases

    eggNOGiCOG1472.
    HOGENOMiHOG000031215.
    KOiK05349.
    OMAiANEQETE.
    OrthoDBiEOG7H799Q.

    Family and domain databases

    Gene3Di3.20.20.300. 1 hit.
    3.40.50.1700. 3 hits.
    InterProiIPR026891. Fn3-like.
    IPR026892. Glyco_hydro_3.
    IPR019800. Glyco_hydro_3_AS.
    IPR002772. Glyco_hydro_3_C.
    IPR001764. Glyco_hydro_3_N.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR30620. PTHR30620. 1 hit.
    PfamiPF14310. Fn3-like. 1 hit.
    PF00933. Glyco_hydro_3. 1 hit.
    PF01915. Glyco_hydro_3_C. 1 hit.
    [Graphical view]
    PRINTSiPR00133. GLHYDRLASE3.
    SUPFAMiSSF51445. SSF51445. 1 hit.
    SSF52279. SSF52279. 3 hits.
    PROSITEiPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5BFG8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFQKVDPAQ IESVLSKLTL EEKISLLAGK NFWETQDYPE KGVPPVKTSD    50
    GPNGARGATF KGGVTAACFP ASSLLAATWD LDAAKHIGEA LADETRSKGA 100
    RVLLAPTVCI HRHPLGGRNF ESFSEDPFLA GKLAAQYIKG LQGNGVAATI 150
    KHYAANEQET CRFTVNEHIT ERALREIYLK PFEIAIKESN PLAVMTAYNI 200
    VNGTHADSNN FLLRDVLRGE WGWKGLVMSD WGGTNSTADA LNAGLDLEMP 250
    GPTRWRKVDE VLAVVKSGAV LEETIDERAR NVLELLAKLN CFENPTIPEE 300
    KAINRPEHQK LIRSVGSQGL VLLKNEGDVL PLRKEILTNK KVALLGFARE 350
    ALIHGGGSAS VNAHYRVTPE EGLRAALGDT VEFEYAKGAH TFRQLPLMSD 400
    NVVNLEGQPG WTLDFFADEE PNGEPGSSIS SEQPSYIPLF VKESWGSVRA 450
    SAHFTPTQSG KHYFGMSGLG RSKLLIDGEV IYEQKLNCPD SMGFLLGGVE 500
    EPEIQYSFEA GKTYAVEVVS VKPTSKGGLA LLDGFIGFRL GFMTEEEHNR 550
    DLLSEAVDVA KRSDIAIVFT GHTPDWETEG QDQISFHLPS NGSQDRLVAA 600
    VGAANPNTVV VNCTGVAVAM PWLDKVKAVV QAWFPGQEAG NAIADVLTGA 650
    VNPSGRLPVS FPRAIEDAPA HGNFPGDYTD GKDNRRHLEV TYKEGVFVGY 700
    RHYDLSEANR AKVLFPFGYG LSYTTFTHAN HKASATSRNT VEVAVDVTNV 750
    GTCAGADVVQ VYAGAKLAVP ENPVKELVGF AKVHLKPGET KTANITFEVR 800
    QLTHFTERSG KWELESGDYE ISIGQSVRDI TGKVEIGLEA QNYKP 845
    Length:845
    Mass (Da):91,790
    Last modified:April 26, 2005 - v1
    Checksum:iAEB0E7A749BC0C25
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ490467 mRNA. Translation: ABF50843.1.
    AACD01000011 Genomic DNA. Translation: EAA65189.1.
    BN001308 Genomic DNA. Translation: CBF88936.1.
    RefSeqiXP_658316.1. XM_653224.1.

    Genome annotation databases

    EnsemblFungiiCADANIAT00001957; CADANIAP00001957; CADANIAG00001957.
    GeneIDi2876490.
    KEGGiani:AN0712.2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ490467 mRNA. Translation: ABF50843.1 .
    AACD01000011 Genomic DNA. Translation: EAA65189.1 .
    BN001308 Genomic DNA. Translation: CBF88936.1 .
    RefSeqi XP_658316.1. XM_653224.1.

    3D structure databases

    ProteinModelPortali Q5BFG8.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADANIAT00001957 ; CADANIAP00001957 ; CADANIAG00001957 .
    GeneIDi 2876490.
    KEGGi ani:AN0712.2.

    Phylogenomic databases

    eggNOGi COG1472.
    HOGENOMi HOG000031215.
    KOi K05349.
    OMAi ANEQETE.
    OrthoDBi EOG7H799Q.

    Enzyme and pathway databases

    UniPathwayi UPA00696 .

    Family and domain databases

    Gene3Di 3.20.20.300. 1 hit.
    3.40.50.1700. 3 hits.
    InterProi IPR026891. Fn3-like.
    IPR026892. Glyco_hydro_3.
    IPR019800. Glyco_hydro_3_AS.
    IPR002772. Glyco_hydro_3_C.
    IPR001764. Glyco_hydro_3_N.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR30620. PTHR30620. 1 hit.
    Pfami PF14310. Fn3-like. 1 hit.
    PF00933. Glyco_hydro_3. 1 hit.
    PF01915. Glyco_hydro_3_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00133. GLHYDRLASE3.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    SSF52279. SSF52279. 3 hits.
    PROSITEi PS00775. GLYCOSYL_HYDROL_F3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Development and application of a suite of polysaccharide-degrading enzymes for analyzing plant cell walls."
      Bauer S., Vasu P., Persson S., Mort A.J., Somerville C.R.
      Proc. Natl. Acad. Sci. U.S.A. 103:11417-11422(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
    3. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
      Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
      , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
      Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

    Entry informationi

    Entry nameiBGLB_EMENI
    AccessioniPrimary (citable) accession number: Q5BFG8
    Secondary accession number(s): C8VRC8, Q1HFV7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 18, 2010
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3