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Q5BFG8 (BGLB_EMENI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-glucosidase B

EC=3.2.1.21
Alternative name(s):
Beta-D-glucoside glucohydrolase B
Cellobiase B
Gentiobiase B
Gene names
Name:bglB
ORF Names:AN0712
OrganismEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) [Reference proteome]
Taxonomic identifier227321 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length845 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose. Ref.1

Catalytic activity

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathway

Glycan metabolism; cellulose degradation.

Sequence similarities

Belongs to the glycosyl hydrolase 3 family.

Biophysicochemical properties

pH dependence:

Optimum pH is 5.5. Ref.1

Temperature dependence:

Optimum temperature is 52 degrees Celsius.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 845845Beta-glucosidase B
PRO_0000394102

Sites

Active site2301 By similarity

Amino acid modifications

Glycosylation2021N-linked (GlcNAc...) Potential
Glycosylation2351N-linked (GlcNAc...) Potential
Glycosylation5911N-linked (GlcNAc...) Potential
Glycosylation6121N-linked (GlcNAc...) Potential
Glycosylation7941N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q5BFG8 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: AEB0E7A749BC0C25

FASTA84591,790
        10         20         30         40         50         60 
MSFQKVDPAQ IESVLSKLTL EEKISLLAGK NFWETQDYPE KGVPPVKTSD GPNGARGATF 

        70         80         90        100        110        120 
KGGVTAACFP ASSLLAATWD LDAAKHIGEA LADETRSKGA RVLLAPTVCI HRHPLGGRNF 

       130        140        150        160        170        180 
ESFSEDPFLA GKLAAQYIKG LQGNGVAATI KHYAANEQET CRFTVNEHIT ERALREIYLK 

       190        200        210        220        230        240 
PFEIAIKESN PLAVMTAYNI VNGTHADSNN FLLRDVLRGE WGWKGLVMSD WGGTNSTADA 

       250        260        270        280        290        300 
LNAGLDLEMP GPTRWRKVDE VLAVVKSGAV LEETIDERAR NVLELLAKLN CFENPTIPEE 

       310        320        330        340        350        360 
KAINRPEHQK LIRSVGSQGL VLLKNEGDVL PLRKEILTNK KVALLGFARE ALIHGGGSAS 

       370        380        390        400        410        420 
VNAHYRVTPE EGLRAALGDT VEFEYAKGAH TFRQLPLMSD NVVNLEGQPG WTLDFFADEE 

       430        440        450        460        470        480 
PNGEPGSSIS SEQPSYIPLF VKESWGSVRA SAHFTPTQSG KHYFGMSGLG RSKLLIDGEV 

       490        500        510        520        530        540 
IYEQKLNCPD SMGFLLGGVE EPEIQYSFEA GKTYAVEVVS VKPTSKGGLA LLDGFIGFRL 

       550        560        570        580        590        600 
GFMTEEEHNR DLLSEAVDVA KRSDIAIVFT GHTPDWETEG QDQISFHLPS NGSQDRLVAA 

       610        620        630        640        650        660 
VGAANPNTVV VNCTGVAVAM PWLDKVKAVV QAWFPGQEAG NAIADVLTGA VNPSGRLPVS 

       670        680        690        700        710        720 
FPRAIEDAPA HGNFPGDYTD GKDNRRHLEV TYKEGVFVGY RHYDLSEANR AKVLFPFGYG 

       730        740        750        760        770        780 
LSYTTFTHAN HKASATSRNT VEVAVDVTNV GTCAGADVVQ VYAGAKLAVP ENPVKELVGF 

       790        800        810        820        830        840 
AKVHLKPGET KTANITFEVR QLTHFTERSG KWELESGDYE ISIGQSVRDI TGKVEIGLEA 


QNYKP 

« Hide

References

« Hide 'large scale' references
[1]"Development and application of a suite of polysaccharide-degrading enzymes for analyzing plant cell walls."
Bauer S., Vasu P., Persson S., Mort A.J., Somerville C.R.
Proc. Natl. Acad. Sci. U.S.A. 103:11417-11422(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
[2]"Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae."
Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H. expand/collapse author list , Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L., Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.
Nature 438:1105-1115(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
[3]"The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G. expand/collapse author list , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ490467 mRNA. Translation: ABF50843.1.
AACD01000011 Genomic DNA. Translation: EAA65189.1.
BN001308 Genomic DNA. Translation: CBF88936.1.
RefSeqXP_658316.1. XM_653224.1.

3D structure databases

ProteinModelPortalQ5BFG8.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADANIAT00001957; CADANIAP00001957; CADANIAG00001957.
GeneID2876490.
KEGGani:AN0712.2.

Phylogenomic databases

eggNOGCOG1472.
HOGENOMHOG000031215.
KOK05349.
OMAANEQETE.
OrthoDBEOG7H799Q.

Enzyme and pathway databases

UniPathwayUPA00696.

Family and domain databases

Gene3D3.20.20.300. 1 hit.
3.40.50.1700. 3 hits.
InterProIPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR019800. Glyco_hydro_3_AS.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERPTHR30620. PTHR30620. 1 hit.
PfamPF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
[Graphical view]
PRINTSPR00133. GLHYDRLASE3.
SUPFAMSSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 3 hits.
PROSITEPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBGLB_EMENI
AccessionPrimary (citable) accession number: Q5BFG8
Secondary accession number(s): C8VRC8, Q1HFV7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: April 26, 2005
Last modified: January 22, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries