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Q5BEQ0

- BGALB_EMENI

UniProt

Q5BEQ0 - BGALB_EMENI

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Protein
Probable beta-galactosidase B
Gene
lacB, AN0980
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans By similarity.

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei90 – 901Substrate By similarity
Binding sitei135 – 1351Substrate By similarity
Binding sitei136 – 1361Substrate; via amide nitrogen By similarity
Binding sitei137 – 1371Substrate By similarity
Binding sitei195 – 1951Substrate By similarity
Active sitei196 – 1961Proton donor Reviewed prediction
Binding sitei265 – 2651Substrate By similarity
Active sitei308 – 3081Nucleophile Reviewed prediction
Binding sitei373 – 3731Substrate By similarity

GO - Molecular functioni

  1. beta-galactosidase activity Source: ASPGD

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation

Protein family/group databases

CAZyiGH35. Glycoside Hydrolase Family 35.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-galactosidase B (EC:3.2.1.23)
Alternative name(s):
Lactase B
Gene namesi
Name:lacB
ORF Names:AN0980
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome VIII

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 10251004Probable beta-galactosidase B
PRO_0000395229Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi23 – 231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi100 – 1001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi211 – 2111N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi271 ↔ 324 By similarity
Glycosylationi411 – 4111N-linked (GlcNAc...) Reviewed prediction
Glycosylationi456 – 4561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi736 – 7361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi776 – 7761N-linked (GlcNAc...) Reviewed prediction
Glycosylationi884 – 8841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi925 – 9251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi926 – 9261N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00001672.

Structurei

3D structure databases

ProteinModelPortaliQ5BEQ0.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1874.
HOGENOMiHOG000181922.
OrthoDBiEOG7ZGXBD.

Family and domain databases

Gene3Di2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSiPR00742. GLHYDRLASE35.
SMARTiSM01029. BetaGal_dom2. 1 hit.
[Graphical view]
SUPFAMiSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5BEQ0-1 [UniParc]FASTAAdd to Basket

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MATAFWLLLF LLGSLHVLTA AQNSSQSEWP IHDNGLSKVV QWDHYSFYIN     50
GQRIFLFSGE FHYWRIPVPA LWRDILEKIK AIGFTGFAFY SSWAYHAPNN 100
QTVDFSTGAR DITPIYDLAK ELGMYIIVRP GPYVNAEASA GGFPLWLTTG 150
AYGSTRNDDP RYTAAWEPYF AEVSEITSKY QVTDGHYTLC YQIENEYGQQ 200
WIGDPRDRNP NQTAIAYMEL LQASARENGI TVPLTGNDPN MNTKSWGSDW 250
SDAGGNLDTV GLDSYPSCWS CDVSVCTGTN GEYVPYKVLD YYDYFQEVQP 300
TMPFFMPEFQ GGSYNPWDGP EGGCTEDTGA DFANLFYRWN IGQRVSAMSL 350
YMMFGGTNWG GIAAPVTASS YDYSAPISED RSIGSKYYET KLLALFTRCA 400
KDLTMTDRLG NGTQYTDNEA VIASELRNPD TNAAFYVTTH LDTTVGTDES 450
FKLHVNTSKG ALTIPRHGGT IRLNGHHSKI IVTDFNFGSE TLLYSTAEVL 500
TYAVFDRKPT LVLWVPTGES GEFAIKGAKS GSVAKCSGCS NIKFHRDSGS 550
LTVAFTQGEG ISVLQLDNGV RVVLLDRQKA YTFWAPALTD NPLVPEGESV 600
LVSGPYLVRT ARLARSTLTL RGDSKGETLE IFAPRKIKKV TWNGKAVEAT 650
RTSYGSLKAI LAKPPSVELP TLNGWKYSDS LPERFPTYDD SGAAWVEIDA 700
NHMTTPNPNK PATLPVLYAD EYGFHNGVRL WRGYFNSSAS GVYLNIQGGA 750
AFGWSAWLNG HFLGSHLGSA SIQQANGTLD FPANTLNTEG TPNVLLVVHD 800
DTGHDQTTGV LNPRGILEAR LLSEASDNND DDSPGFTHWR VAGTAGGESD 850
LDPVRGVYNE DGLYAERVGW HLPGFDDSKW ATVNGTSLSF TGATVRFFRT 900
VIPPLSIPEN TDVSISFVFS TPNVNNTSAG NTSAFRAQLF VNGYQYGRYN 950
PYVGNQVVYP VPPGILDYNG ENTIGVAVWA QTEAGARLNL DWRVNYVLGS 1000
SLDAGRLDLS FVAIAYVYIF ECLQL 1025
Length:1,025
Mass (Da):112,791
Last modified:July 13, 2010 - v2
Checksum:i042F7E48B07F2BD4
GO

Sequence cautioni

The sequence CBF88404.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence EAA66009.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACD01000014 Genomic DNA. Translation: EAA66009.1. Sequence problems.
BN001308 Genomic DNA. Translation: CBF88404.1. Sequence problems.
RefSeqiXP_658584.1. XM_653492.1.

Genome annotation databases

EnsemblFungiiCADANIAT00001672; CADANIAP00001672; CADANIAG00001672.
GeneIDi2876757.
KEGGiani:AN0980.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACD01000014 Genomic DNA. Translation: EAA66009.1 . Sequence problems.
BN001308 Genomic DNA. Translation: CBF88404.1 . Sequence problems.
RefSeqi XP_658584.1. XM_653492.1.

3D structure databases

ProteinModelPortali Q5BEQ0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 162425.CADANIAP00001672.

Protein family/group databases

CAZyi GH35. Glycoside Hydrolase Family 35.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00001672 ; CADANIAP00001672 ; CADANIAG00001672 .
GeneIDi 2876757.
KEGGi ani:AN0980.2.

Phylogenomic databases

eggNOGi COG1874.
HOGENOMi HOG000181922.
OrthoDBi EOG7ZGXBD.

Family and domain databases

Gene3Di 2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR23421. PTHR23421. 1 hit.
Pfami PF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view ]
PRINTSi PR00742. GLHYDRLASE35.
SMARTi SM01029. BetaGal_dom2. 1 hit.
[Graphical view ]
SUPFAMi SSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiBGALB_EMENI
AccessioniPrimary (citable) accession number: Q5BEQ0
Secondary accession number(s): C8VU89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: April 16, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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