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Protein

Pheromone-processing carboxypeptidase kex1

Gene

kex1

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei188PROSITE-ProRule annotation1
Active sitei387PROSITE-ProRule annotation1
Active sitei449PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease
Biological processApoptosis

Protein family/group databases

ESTHERiemeni-q7si81 Carboxypeptidase_S10
MEROPSiC98.001

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase kex1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:kex1
ORF Names:AN1384
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome VIII
  • UP000005890 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini36 – 520LumenalSequence analysisAdd BLAST485
Transmembranei521 – 541HelicalSequence analysisAdd BLAST21
Topological domaini542 – 631CytoplasmicSequence analysisAdd BLAST90

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000041192036 – 631Pheromone-processing carboxypeptidase kex1Add BLAST596

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi438N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi446N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi498N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ5BDJ6

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00001223

Structurei

3D structure databases

ProteinModelPortaliQ5BDJ6
SMRiQ5BDJ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000208879
InParanoidiQ5BDJ6
KOiK01288
OMAiMLDRFMG
OrthoDBiEOG092C255X

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR018202 Ser_caboxypep_ser_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00131 CARBOXYPEPT_SER_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5BDJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLSFRQPS WRISRSQFYP IWALSQLLLN PIAVLAQSAA DYYVESLPGA
60 70 80 90 100
PEGPLLKMHA GHIEVDPEHN GHLFFWHYQN RHIANRQRTI IWLNGGPGCS
110 120 130 140 150
SMDGALMEIG PYRLKDNETL EYNEGSWDEF ANLLFVDQPV GTGFSFANTN
160 170 180 190 200
SYLHELDEMA AQFITFLEKW FAVFPEYERD DIYIAGESYA GQYIPYIAKA
210 220 230 240 250
IQDRNKDIHE KQSSSARWNL RGLLIGNGWI SPAEQYPAYL SFAYEEGLVE
260 270 280 290 300
EGSKLGKELE TLLSICKSKM ETGPKISITD CEAVLNKLLD KTVDSNNQCI
310 320 330 340 350
NMYDIRLRDG SCGTTWPPDL VDVKPYLHTY EVIQALNISP EKESGWDECD
360 370 380 390 400
GNVGAAFRPQ KSEPSVKLLP GLLESGIEIL LFSGDKDLIC NHVGTEQLIS
410 420 430 440 450
NMKWAGGTGF ETSPGVWAPR HDWTFEDEPA GYYQYARNLT YVLLYNASHM
460 470 480 490 500
APFDLPRRTR DMVDRFMHVD IASIGGAPAD SRIDGEPLPQ TSVGGQPNST
510 520 530 540 550
VHQEEEQQKI KETEWNAYAK SGEAVLVVVI IGVLVWGFLI WRSRRRHNGY
560 570 580 590 600
SGIAIKSPSR TSIMGRFHNN HSNGADVEAG DFDEAELDDL HSPGLDRENY
610 620 630
AVGEDSDDEA HRQDLPRAQE SSSKSENNLV T
Length:631
Mass (Da):70,870
Last modified:July 27, 2011 - v2
Checksum:iB457AC0F569D3442
GO

Sequence cautioni

The sequence EAA65214 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BK001295 Genomic DNA Translation: DAA01786.1
AACD01000019 Genomic DNA Translation: EAA65214.1 Sequence problems.
BN001308 Genomic DNA Translation: CBF87602.1
RefSeqiXP_658988.1, XM_653896.1

Genome annotation databases

EnsemblFungiiCADANIAT00001223; CADANIAP00001223; CADANIAG00001223
EAA65214; EAA65214; AN1384.2
GeneIDi2877162
KEGGiani:AN1384.2

Similar proteinsi

Entry informationi

Entry nameiKEX1_EMENI
AccessioniPrimary (citable) accession number: Q5BDJ6
Secondary accession number(s): C8VRU1, Q7SI81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 73 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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