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Q5BDJ6

- KEX1_EMENI

UniProt

Q5BDJ6 - KEX1_EMENI

Protein

Pheromone-processing carboxypeptidase kex1

Gene

kex1

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei188 – 1881PROSITE-ProRule annotation
    Active sitei387 – 3871PROSITE-ProRule annotation
    Active sitei449 – 4491PROSITE-ProRule annotation

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Apoptosis

    Protein family/group databases

    MEROPSiC98.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pheromone-processing carboxypeptidase kex1 (EC:3.4.16.6)
    Alternative name(s):
    Carboxypeptidase D
    Gene namesi
    Name:kex1
    ORF Names:AN1384
    OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
    Taxonomic identifieri227321 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000000560: Chromosome VIII

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3535Sequence AnalysisAdd
    BLAST
    Chaini36 – 631596Pheromone-processing carboxypeptidase kex1PRO_0000411920Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi438 – 4381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi446 – 4461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi498 – 4981N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi162425.CADANIAP00001223.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5BDJ6.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini36 – 520485LumenalSequence AnalysisAdd
    BLAST
    Topological domaini542 – 63190CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei521 – 54121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2428.
    HOGENOMiHOG000208879.
    KOiK01288.
    OMAiCERAINI.
    OrthoDBiEOG7TJ3SJ.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5BDJ6-1 [UniParc]FASTAAdd to Basket

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    MGLLSFRQPS WRISRSQFYP IWALSQLLLN PIAVLAQSAA DYYVESLPGA    50
    PEGPLLKMHA GHIEVDPEHN GHLFFWHYQN RHIANRQRTI IWLNGGPGCS 100
    SMDGALMEIG PYRLKDNETL EYNEGSWDEF ANLLFVDQPV GTGFSFANTN 150
    SYLHELDEMA AQFITFLEKW FAVFPEYERD DIYIAGESYA GQYIPYIAKA 200
    IQDRNKDIHE KQSSSARWNL RGLLIGNGWI SPAEQYPAYL SFAYEEGLVE 250
    EGSKLGKELE TLLSICKSKM ETGPKISITD CEAVLNKLLD KTVDSNNQCI 300
    NMYDIRLRDG SCGTTWPPDL VDVKPYLHTY EVIQALNISP EKESGWDECD 350
    GNVGAAFRPQ KSEPSVKLLP GLLESGIEIL LFSGDKDLIC NHVGTEQLIS 400
    NMKWAGGTGF ETSPGVWAPR HDWTFEDEPA GYYQYARNLT YVLLYNASHM 450
    APFDLPRRTR DMVDRFMHVD IASIGGAPAD SRIDGEPLPQ TSVGGQPNST 500
    VHQEEEQQKI KETEWNAYAK SGEAVLVVVI IGVLVWGFLI WRSRRRHNGY 550
    SGIAIKSPSR TSIMGRFHNN HSNGADVEAG DFDEAELDDL HSPGLDRENY 600
    AVGEDSDDEA HRQDLPRAQE SSSKSENNLV T 631
    Length:631
    Mass (Da):70,870
    Last modified:July 27, 2011 - v2
    Checksum:iB457AC0F569D3442
    GO

    Sequence cautioni

    The sequence EAA65214.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BK001295 Genomic DNA. Translation: DAA01786.1.
    AACD01000019 Genomic DNA. Translation: EAA65214.1. Sequence problems.
    BN001308 Genomic DNA. Translation: CBF87602.1.
    RefSeqiXP_658988.1. XM_653896.1.

    Genome annotation databases

    EnsemblFungiiCADANIAT00001223; CADANIAP00001223; CADANIAG00001223.
    GeneIDi2877162.
    KEGGiani:AN1384.2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BK001295 Genomic DNA. Translation: DAA01786.1 .
    AACD01000019 Genomic DNA. Translation: EAA65214.1 . Sequence problems.
    BN001308 Genomic DNA. Translation: CBF87602.1 .
    RefSeqi XP_658988.1. XM_653896.1.

    3D structure databases

    ProteinModelPortali Q5BDJ6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 162425.CADANIAP00001223.

    Protein family/group databases

    MEROPSi C98.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADANIAT00001223 ; CADANIAP00001223 ; CADANIAG00001223 .
    GeneIDi 2877162.
    KEGGi ani:AN1384.2.

    Phylogenomic databases

    eggNOGi COG2428.
    HOGENOMi HOG000208879.
    KOi K01288.
    OMAi CERAINI.
    OrthoDBi EOG7TJ3SJ.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomics reveals sexual secrets of Aspergillus."
      Dyer P.S., Paoletti M., Archer D.B.
      Microbiology 149:2301-2303(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
    3. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
      Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
      , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
      Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

    Entry informationi

    Entry nameiKEX1_EMENI
    AccessioniPrimary (citable) accession number: Q5BDJ6
    Secondary accession number(s): C8VRU1, Q7SI81
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 53 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3