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Protein

Pheromone-processing carboxypeptidase kex1

Gene

kex1

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei188 – 1881PROSITE-ProRule annotation
Active sitei387 – 3871PROSITE-ProRule annotation
Active sitei449 – 4491PROSITE-ProRule annotation

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiC98.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase kex1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:kex1
ORF Names:AN1384
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560 Componenti: Chromosome VIII

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini36 – 520485LumenalSequence AnalysisAdd
BLAST
Transmembranei521 – 54121HelicalSequence AnalysisAdd
BLAST
Topological domaini542 – 63190CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535Sequence AnalysisAdd
BLAST
Chaini36 – 631596Pheromone-processing carboxypeptidase kex1PRO_0000411920Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi438 – 4381N-linked (GlcNAc...)Sequence Analysis
Glycosylationi446 – 4461N-linked (GlcNAc...)Sequence Analysis
Glycosylationi498 – 4981N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00001223.

Structurei

3D structure databases

ProteinModelPortaliQ5BDJ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2428.
HOGENOMiHOG000208879.
InParanoidiQ5BDJ6.
KOiK01288.
OMAiCERAINI.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5BDJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLSFRQPS WRISRSQFYP IWALSQLLLN PIAVLAQSAA DYYVESLPGA
60 70 80 90 100
PEGPLLKMHA GHIEVDPEHN GHLFFWHYQN RHIANRQRTI IWLNGGPGCS
110 120 130 140 150
SMDGALMEIG PYRLKDNETL EYNEGSWDEF ANLLFVDQPV GTGFSFANTN
160 170 180 190 200
SYLHELDEMA AQFITFLEKW FAVFPEYERD DIYIAGESYA GQYIPYIAKA
210 220 230 240 250
IQDRNKDIHE KQSSSARWNL RGLLIGNGWI SPAEQYPAYL SFAYEEGLVE
260 270 280 290 300
EGSKLGKELE TLLSICKSKM ETGPKISITD CEAVLNKLLD KTVDSNNQCI
310 320 330 340 350
NMYDIRLRDG SCGTTWPPDL VDVKPYLHTY EVIQALNISP EKESGWDECD
360 370 380 390 400
GNVGAAFRPQ KSEPSVKLLP GLLESGIEIL LFSGDKDLIC NHVGTEQLIS
410 420 430 440 450
NMKWAGGTGF ETSPGVWAPR HDWTFEDEPA GYYQYARNLT YVLLYNASHM
460 470 480 490 500
APFDLPRRTR DMVDRFMHVD IASIGGAPAD SRIDGEPLPQ TSVGGQPNST
510 520 530 540 550
VHQEEEQQKI KETEWNAYAK SGEAVLVVVI IGVLVWGFLI WRSRRRHNGY
560 570 580 590 600
SGIAIKSPSR TSIMGRFHNN HSNGADVEAG DFDEAELDDL HSPGLDRENY
610 620 630
AVGEDSDDEA HRQDLPRAQE SSSKSENNLV T
Length:631
Mass (Da):70,870
Last modified:July 26, 2011 - v2
Checksum:iB457AC0F569D3442
GO

Sequence cautioni

The sequence EAA65214.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BK001295 Genomic DNA. Translation: DAA01786.1.
AACD01000019 Genomic DNA. Translation: EAA65214.1. Sequence problems.
BN001308 Genomic DNA. Translation: CBF87602.1.
RefSeqiXP_658988.1. XM_653896.1.

Genome annotation databases

EnsemblFungiiCADANIAT00001223; CADANIAP00001223; CADANIAG00001223.
GeneIDi2877162.
KEGGiani:AN1384.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BK001295 Genomic DNA. Translation: DAA01786.1.
AACD01000019 Genomic DNA. Translation: EAA65214.1. Sequence problems.
BN001308 Genomic DNA. Translation: CBF87602.1.
RefSeqiXP_658988.1. XM_653896.1.

3D structure databases

ProteinModelPortaliQ5BDJ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi162425.CADANIAP00001223.

Protein family/group databases

MEROPSiC98.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADANIAT00001223; CADANIAP00001223; CADANIAG00001223.
GeneIDi2877162.
KEGGiani:AN1384.2.

Phylogenomic databases

eggNOGiCOG2428.
HOGENOMiHOG000208879.
InParanoidiQ5BDJ6.
KOiK01288.
OMAiCERAINI.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genomics reveals sexual secrets of Aspergillus."
    Dyer P.S., Paoletti M., Archer D.B.
    Microbiology 149:2301-2303(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  3. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiKEX1_EMENI
AccessioniPrimary (citable) accession number: Q5BDJ6
Secondary accession number(s): C8VRU1, Q7SI81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 26, 2011
Last sequence update: July 26, 2011
Last modified: January 6, 2015
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.