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Q5BDJ6 (KEX1_EMENI) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pheromone-processing carboxypeptidase kex1

EC=3.4.16.6
Alternative name(s):
Carboxypeptidase D
Gene names
Name:kex1
ORF Names:AN1384
OrganismEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) [Reference proteome]
Taxonomic identifier227321 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length631 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Sequence caution

The sequence EAA65214.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentGolgi apparatus
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3535 Potential
Chain36 – 631596Pheromone-processing carboxypeptidase kex1
PRO_0000411920

Regions

Topological domain36 – 520485Lumenal Potential
Transmembrane521 – 54121Helical; Potential
Topological domain542 – 63190Cytoplasmic Potential

Sites

Active site1881 By similarity
Active site3871 By similarity
Active site4491 By similarity

Amino acid modifications

Glycosylation1171N-linked (GlcNAc...) Potential
Glycosylation4381N-linked (GlcNAc...) Potential
Glycosylation4461N-linked (GlcNAc...) Potential
Glycosylation4981N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q5BDJ6 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: B457AC0F569D3442

FASTA63170,870
        10         20         30         40         50         60 
MGLLSFRQPS WRISRSQFYP IWALSQLLLN PIAVLAQSAA DYYVESLPGA PEGPLLKMHA 

        70         80         90        100        110        120 
GHIEVDPEHN GHLFFWHYQN RHIANRQRTI IWLNGGPGCS SMDGALMEIG PYRLKDNETL 

       130        140        150        160        170        180 
EYNEGSWDEF ANLLFVDQPV GTGFSFANTN SYLHELDEMA AQFITFLEKW FAVFPEYERD 

       190        200        210        220        230        240 
DIYIAGESYA GQYIPYIAKA IQDRNKDIHE KQSSSARWNL RGLLIGNGWI SPAEQYPAYL 

       250        260        270        280        290        300 
SFAYEEGLVE EGSKLGKELE TLLSICKSKM ETGPKISITD CEAVLNKLLD KTVDSNNQCI 

       310        320        330        340        350        360 
NMYDIRLRDG SCGTTWPPDL VDVKPYLHTY EVIQALNISP EKESGWDECD GNVGAAFRPQ 

       370        380        390        400        410        420 
KSEPSVKLLP GLLESGIEIL LFSGDKDLIC NHVGTEQLIS NMKWAGGTGF ETSPGVWAPR 

       430        440        450        460        470        480 
HDWTFEDEPA GYYQYARNLT YVLLYNASHM APFDLPRRTR DMVDRFMHVD IASIGGAPAD 

       490        500        510        520        530        540 
SRIDGEPLPQ TSVGGQPNST VHQEEEQQKI KETEWNAYAK SGEAVLVVVI IGVLVWGFLI 

       550        560        570        580        590        600 
WRSRRRHNGY SGIAIKSPSR TSIMGRFHNN HSNGADVEAG DFDEAELDDL HSPGLDRENY 

       610        620        630 
AVGEDSDDEA HRQDLPRAQE SSSKSENNLV T 

« Hide

References

« Hide 'large scale' references
[1]"Genomics reveals sexual secrets of Aspergillus."
Dyer P.S., Paoletti M., Archer D.B.
Microbiology 149:2301-2303(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
[2]"Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae."
Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H. expand/collapse author list , Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L., Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.
Nature 438:1105-1115(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
[3]"The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G. expand/collapse author list , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BK001295 Genomic DNA. Translation: DAA01786.1.
AACD01000019 Genomic DNA. Translation: EAA65214.1. Sequence problems.
BN001308 Genomic DNA. Translation: CBF87602.1.
RefSeqXP_658988.1. XM_653896.1.

3D structure databases

ProteinModelPortalQ5BDJ6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING162425.CADANIAP00001223.

Protein family/group databases

MEROPSC98.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADANIAT00001223; CADANIAP00001223; CADANIAG00001223.
GeneID2877162.
KEGGani:AN1384.2.

Phylogenomic databases

eggNOGCOG2428.
HOGENOMHOG000208879.
KOK01288.
OMACERAINI.
OrthoDBEOG7TJ3SJ.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKEX1_EMENI
AccessionPrimary (citable) accession number: Q5BDJ6
Secondary accession number(s): C8VRU1, Q7SI81
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 27, 2011
Last modified: June 11, 2014
This is version 52 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries