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Protein

Protein OS-9 homolog

Gene

yos9

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei173CarbohydrateBy similarity1
Binding sitei246CarbohydrateBy similarity1
Binding sitei252CarbohydrateBy similarity1
Binding sitei273CarbohydrateBy similarity1
Binding sitei279CarbohydrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
Protein OS-9 homolog
Gene namesi
Name:yos9
ORF Names:AN1461
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome VII
  • UP000005890 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000004327024 – 509Protein OS-9 homologAdd BLAST486

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi120N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi153 ↔ 166By similarity
Disulfide bondi245 ↔ 277By similarity
Disulfide bondi260 ↔ 289By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Interacts with missfolded ER lumenal proteins.By similarity

Protein-protein interaction databases

STRINGi162425.CADANIAP00008077

Structurei

3D structure databases

SMRiQ5BDB9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini151 – 230PRKCSHAdd BLAST80

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi506 – 509Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the OS-9 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000157538
InParanoidiQ5BDB9
KOiK10088
OMAiVQFHALP
OrthoDBiEOG092C4FPG

Family and domain databases

Gene3Di2.70.130.10, 1 hit
InterProiView protein in InterPro
IPR009011 Man6P_isomerase_rcpt-bd_dom_sf
IPR012913 OS9-like
PfamiView protein in Pfam
PF07915 PRKCSH, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5BDB9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRQSRIVAS LLVLACASSG AFAHRKFNVH DDLLAYPQFR IKFPDGFILE
60 70 80 90 100
SQARAFLEQA PYSSPDLNDI SEQTPLKDES EESIRDGSSG EKAKFSYEEL
110 120 130 140 150
SLEGQRYLCQ IPVVEDGDSN RTKVEVNEEE ERKELARATD RGLELLREME
160 170 180 190 200
GKCLYYISGW WSYSFCYMNQ IKQFHALPSG GGVPNYPPME DHTTHSFILG
210 220 230 240 250
RFPQEEGQDE GKGAKSGKSS TELAELQTKG GSRYLVQRLE SGDQCDLTGK
260 270 280 290 300
NRKIEVQFHC NPQSTDRIAW IKELYTCSYL MLIYTPRLCN DVAFLPPQQE
310 320 330 340 350
EVHTIECREI LTPEEVTGWQ AMHEYQLSQQ LVESAEAPKH QVIGGIEVGA
360 370 380 390 400
QRLVGTEGKR IEKGRVASIG EEKVDVVAKR VNGEVQLLSA EELKKFDLDE
410 420 430 440 450
AKIEELRKKL EEWAKGKDWT LEIVTGNGAY LRGVVDTDED EEDGYENEEG
460 470 480 490 500
ETDKREQREN TQETTGQPGQ PGHQEETESG QAGHPMDDRS EDGEDPDVDG

SEEIFKDEL
Length:509
Mass (Da):57,548
Last modified:April 26, 2005 - v1
Checksum:iAE1741546DB1DAA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000022 Genomic DNA Translation: EAA64591.1
BN001307 Genomic DNA Translation: CBF84906.1
RefSeqiXP_659065.1, XM_653973.1

Genome annotation databases

EnsemblFungiiCADANIAT00008077; CADANIAP00008077; CADANIAG00008077
EAA64591; EAA64591; AN1461.2
GeneIDi2875379
KEGGiani:AN1461.2

Similar proteinsi

Entry informationi

Entry nameiOS9_EMENI
AccessioniPrimary (citable) accession number: Q5BDB9
Secondary accession number(s): C8VMD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: April 26, 2005
Last modified: March 28, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health