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Q5BD77

- HOGA1_EMENI

UniProt

Q5BD77 - HOGA1_EMENI

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Protein

Probable 4-hydroxy-2-oxoglutarate aldolase, mitochondrial

Gene

AN1503

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the final step in the metabolic pathway of hydroxyproline (By similarity). Involved in osmoadaptation.By similarity

Catalytic activityi

4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.

Enzyme regulationi

Inhibited by divalent cations.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei144 – 1441Involved in proton transfer during cleavageBy similarity
Active sitei173 – 1731Schiff-base intermediate with substrateBy similarity

GO - Molecular functioni

  1. 4-hydroxy-2-oxoglutarate aldolase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular response to osmotic stress Source: ASPGD
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Stress response

Keywords - Ligandi

Schiff base

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 4-hydroxy-2-oxoglutarate aldolase, mitochondrial (EC:4.1.3.16)
Alternative name(s):
Dihydrodipicolinate synthase-like
Short name:
DHDPS-like protein
Probable 2-keto-4-hydroxyglutarate aldolase
Short name:
Probable KHG-aldolase
Gene namesi
ORF Names:AN1503
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome VII

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Probable 4-hydroxy-2-oxoglutarate aldolase, mitochondrialPRO_0000348285Add
BLAST

Expressioni

Inductioni

Down-regulated when grown with elevated levels of potassium chloride.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00008128.

Structurei

3D structure databases

ProteinModelPortaliQ5BD77.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni49 – 502Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the DapA family.Curated

Phylogenomic databases

eggNOGiCOG0329.
HOGENOMiHOG000173607.
InParanoidiQ5BD77.
OMAiWLAIKGG.
OrthoDBiEOG7XWQ0F.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR002220. DapA-like.
[Graphical view]
PANTHERiPTHR12128. PTHR12128. 1 hit.
PfamiPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFiPIRSF001365. DHDPS. 1 hit.
PRINTSiPR00146. DHPICSNTHASE.

Sequencei

Sequence statusi: Complete.

Q5BD77-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANRPLVPGV YVPTVAFFAE NEDVDVATVE KHAAYLAKSG VAGIVVQGSN
60 70 80 90 100
GEAVHLDREE RNLITSATRH ALDSVGATSM PVIVGTGAPS TRETINLCKD
110 120 130 140 150
AAAAGGDYVL VLPPSYYKSL VSSAALLDHF RAVADASPIP VLIYNFPGAS
160 170 180 190 200
AGLDLSSDDI LALSSHPNII GTKLTCGNTG KLTRIVAQAG PSFLTFGGSC
210 220 230 240 250
DFTLQTLIGG GAGVIAGTAN IIPRACVRIM ELYRAGRVEE AQKVQAIVAR
260 270 280 290 300
ADWLAIKGGF VAVKSALQSY RGYGQQPRRP CVAPSSEEAA ALKEAFSESI

ELERQLESQ
Length:309
Mass (Da):32,314
Last modified:April 26, 2005 - v1
Checksum:i42D3E59113B43F66
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000023 Genomic DNA. Translation: EAA63816.1.
BN001307 Genomic DNA. Translation: CBF84998.1.
RefSeqiXP_659107.1. XM_654015.1.

Genome annotation databases

EnsemblFungiiCADANIAT00008128; CADANIAP00008128; CADANIAG00008128.
GeneIDi2874981.
KEGGiani:AN1503.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000023 Genomic DNA. Translation: EAA63816.1 .
BN001307 Genomic DNA. Translation: CBF84998.1 .
RefSeqi XP_659107.1. XM_654015.1.

3D structure databases

ProteinModelPortali Q5BD77.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 162425.CADANIAP00008128.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00008128 ; CADANIAP00008128 ; CADANIAG00008128 .
GeneIDi 2874981.
KEGGi ani:AN1503.2.

Phylogenomic databases

eggNOGi COG0329.
HOGENOMi HOG000173607.
InParanoidi Q5BD77.
OMAi WLAIKGG.
OrthoDBi EOG7XWQ0F.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR002220. DapA-like.
[Graphical view ]
PANTHERi PTHR12128. PTHR12128. 1 hit.
Pfami PF00701. DHDPS. 1 hit.
[Graphical view ]
PIRSFi PIRSF001365. DHDPS. 1 hit.
PRINTSi PR00146. DHPICSNTHASE.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  3. "Proteome map of Aspergillus nidulans during osmoadaptation."
    Kim Y., Nandakumar M.P., Marten M.R.
    Fungal Genet. Biol. 44:886-895(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiHOGA1_EMENI
AccessioniPrimary (citable) accession number: Q5BD77
Secondary accession number(s): C8VMN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: April 26, 2005
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3