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Q5BD77 (HOGA1_EMENI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable 4-hydroxy-2-oxoglutarate aldolase, mitochondrial

EC=4.1.3.16
Alternative name(s):
Dihydrodipicolinate synthase-like
Short name=DHDPS-like protein
Probable 2-keto-4-hydroxyglutarate aldolase
Short name=Probable KHG-aldolase
Gene names
ORF Names:AN1503
OrganismEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) [Reference proteome]
Taxonomic identifier227321 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the final step in the metabolic pathway of hydroxyproline By similarity. Involved in osmoadaptation.

Catalytic activity

4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.

Enzyme regulation

Inhibited by divalent cations By similarity.

Induction

Down-regulated when grown with elevated levels of potassium chloride. Ref.3

Sequence similarities

Belongs to the DapA family.

Ontologies

Keywords
   Biological processStress response
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular response to osmotic stress

Inferred from expression pattern Ref.3. Source: ASPGD

   Molecular_function4-hydroxy-2-oxoglutarate aldolase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309Probable 4-hydroxy-2-oxoglutarate aldolase, mitochondrial
PRO_0000348285

Regions

Region49 – 502Substrate binding By similarity

Sites

Active site1731Schiff-base intermediate with substrate By similarity
Site1441Involved in proton transfer during cleavage By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5BD77 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: 42D3E59113B43F66

FASTA30932,314
        10         20         30         40         50         60 
MANRPLVPGV YVPTVAFFAE NEDVDVATVE KHAAYLAKSG VAGIVVQGSN GEAVHLDREE 

        70         80         90        100        110        120 
RNLITSATRH ALDSVGATSM PVIVGTGAPS TRETINLCKD AAAAGGDYVL VLPPSYYKSL 

       130        140        150        160        170        180 
VSSAALLDHF RAVADASPIP VLIYNFPGAS AGLDLSSDDI LALSSHPNII GTKLTCGNTG 

       190        200        210        220        230        240 
KLTRIVAQAG PSFLTFGGSC DFTLQTLIGG GAGVIAGTAN IIPRACVRIM ELYRAGRVEE 

       250        260        270        280        290        300 
AQKVQAIVAR ADWLAIKGGF VAVKSALQSY RGYGQQPRRP CVAPSSEEAA ALKEAFSESI 


ELERQLESQ 

« Hide

References

« Hide 'large scale' references
[1]"Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae."
Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H. expand/collapse author list , Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L., Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.
Nature 438:1105-1115(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
[2]"The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G. expand/collapse author list , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
[3]"Proteome map of Aspergillus nidulans during osmoadaptation."
Kim Y., Nandakumar M.P., Marten M.R.
Fungal Genet. Biol. 44:886-895(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION, IDENTIFICATION BY MASS SPECTROMETRY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACD01000023 Genomic DNA. Translation: EAA63816.1.
BN001307 Genomic DNA. Translation: CBF84998.1.
RefSeqXP_659107.1. XM_654015.1.

3D structure databases

ProteinModelPortalQ5BD77.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING162425.CADANIAP00008128.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADANIAT00008128; CADANIAP00008128; CADANIAG00008128.
GeneID2874981.
KEGGani:AN1503.2.

Phylogenomic databases

eggNOGCOG0329.
HOGENOMHOG000173607.
OMAWLAIKGG.
OrthoDBEOG7XWQ0F.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR002220. DapA-like.
[Graphical view]
PANTHERPTHR12128. PTHR12128. 1 hit.
PfamPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFPIRSF001365. DHDPS. 1 hit.
PRINTSPR00146. DHPICSNTHASE.
ProtoNetSearch...

Entry information

Entry nameHOGA1_EMENI
AccessionPrimary (citable) accession number: Q5BD77
Secondary accession number(s): C8VMN4
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: April 26, 2005
Last modified: January 22, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families