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Q5BD77

- HOGA1_EMENI

UniProt

Q5BD77 - HOGA1_EMENI

Protein

Probable 4-hydroxy-2-oxoglutarate aldolase, mitochondrial

Gene

AN1503

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the final step in the metabolic pathway of hydroxyproline By similarity. Involved in osmoadaptation.By similarity

    Catalytic activityi

    4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.

    Enzyme regulationi

    Inhibited by divalent cations.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei144 – 1441Involved in proton transfer during cleavageBy similarity
    Active sitei173 – 1731Schiff-base intermediate with substrateBy similarity

    GO - Molecular functioni

    1. 4-hydroxy-2-oxoglutarate aldolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular response to osmotic stress Source: ASPGD

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Stress response

    Keywords - Ligandi

    Schiff base

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable 4-hydroxy-2-oxoglutarate aldolase, mitochondrial (EC:4.1.3.16)
    Alternative name(s):
    Dihydrodipicolinate synthase-like
    Short name:
    DHDPS-like protein
    Probable 2-keto-4-hydroxyglutarate aldolase
    Short name:
    Probable KHG-aldolase
    Gene namesi
    ORF Names:AN1503
    OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
    Taxonomic identifieri227321 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000000560: Chromosome VII

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 309309Probable 4-hydroxy-2-oxoglutarate aldolase, mitochondrialPRO_0000348285Add
    BLAST

    Expressioni

    Inductioni

    Down-regulated when grown with elevated levels of potassium chloride.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi162425.CADANIAP00008128.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5BD77.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni49 – 502Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the DapA family.Curated

    Phylogenomic databases

    eggNOGiCOG0329.
    HOGENOMiHOG000173607.
    OMAiWLAIKGG.
    OrthoDBiEOG7XWQ0F.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR002220. DapA-like.
    [Graphical view]
    PANTHERiPTHR12128. PTHR12128. 1 hit.
    PfamiPF00701. DHDPS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001365. DHDPS. 1 hit.
    PRINTSiPR00146. DHPICSNTHASE.

    Sequencei

    Sequence statusi: Complete.

    Q5BD77-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANRPLVPGV YVPTVAFFAE NEDVDVATVE KHAAYLAKSG VAGIVVQGSN    50
    GEAVHLDREE RNLITSATRH ALDSVGATSM PVIVGTGAPS TRETINLCKD 100
    AAAAGGDYVL VLPPSYYKSL VSSAALLDHF RAVADASPIP VLIYNFPGAS 150
    AGLDLSSDDI LALSSHPNII GTKLTCGNTG KLTRIVAQAG PSFLTFGGSC 200
    DFTLQTLIGG GAGVIAGTAN IIPRACVRIM ELYRAGRVEE AQKVQAIVAR 250
    ADWLAIKGGF VAVKSALQSY RGYGQQPRRP CVAPSSEEAA ALKEAFSESI 300
    ELERQLESQ 309
    Length:309
    Mass (Da):32,314
    Last modified:April 26, 2005 - v1
    Checksum:i42D3E59113B43F66
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACD01000023 Genomic DNA. Translation: EAA63816.1.
    BN001307 Genomic DNA. Translation: CBF84998.1.
    RefSeqiXP_659107.1. XM_654015.1.

    Genome annotation databases

    EnsemblFungiiCADANIAT00008128; CADANIAP00008128; CADANIAG00008128.
    GeneIDi2874981.
    KEGGiani:AN1503.2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACD01000023 Genomic DNA. Translation: EAA63816.1 .
    BN001307 Genomic DNA. Translation: CBF84998.1 .
    RefSeqi XP_659107.1. XM_654015.1.

    3D structure databases

    ProteinModelPortali Q5BD77.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 162425.CADANIAP00008128.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADANIAT00008128 ; CADANIAP00008128 ; CADANIAG00008128 .
    GeneIDi 2874981.
    KEGGi ani:AN1503.2.

    Phylogenomic databases

    eggNOGi COG0329.
    HOGENOMi HOG000173607.
    OMAi WLAIKGG.
    OrthoDBi EOG7XWQ0F.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR002220. DapA-like.
    [Graphical view ]
    PANTHERi PTHR12128. PTHR12128. 1 hit.
    Pfami PF00701. DHDPS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001365. DHDPS. 1 hit.
    PRINTSi PR00146. DHPICSNTHASE.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
    2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
      Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
      , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
      Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
    3. "Proteome map of Aspergillus nidulans during osmoadaptation."
      Kim Y., Nandakumar M.P., Marten M.R.
      Fungal Genet. Biol. 44:886-895(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiHOGA1_EMENI
    AccessioniPrimary (citable) accession number: Q5BD77
    Secondary accession number(s): C8VMN4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3