Reviewed, UniProtKB/Swiss-Prot Q5BCU8 (ATG1_EMENI)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein kinase atg1
    EC=2.7.11.1
Alternative name(s):
    Autophagy-related protein 1

Gene names

Name:	atg1
ORF Names:	AN1632

Organism

Emericella nidulans (Aspergillus nidulans)

Taxonomic identifier

162425 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › Emericella

Protein attributes

Sequence length	935 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Serine/threonine protein kinase probably involved in the cytoplasm to vacuole transport (Cvt) and in autophagy, where it may be required for the formation of autophagosomes By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Gene Ontology (GO)
Biological process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 935	935	Serine/threonine-protein kinase atg1		PRO_0000085646
Regions
	Domain	24 – 332	309	Protein kinase
	Nucleotide binding	30 – 38	9	ATP By similarity
Sites
	Active site	167	1	Proton acceptor By similarity
	Binding site	53	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5BCU8-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 186E003D22AADCCA	FASTA	935	102,694
	10 20 30 40 50 60 MASTPSKSSR SSKEAYSEVA IGPYTRLDHI GKGSFATVYR GVQTKSRTFV AIKSVNLGKL 70 80 90 100 110 120 NRKLKDNLAM EIDILKYLLH PHIVALLDCL ETNSHIHLIM EYCALGDLSQ FIKRRDSLKD 130 140 150 160 170 180 HSYTRHMISK YPNVSGGALN EVIVRHFLKQ LASALRFLRD KNLIHRDIKP QNLLLCPAPK 190 200 210 220 230 240 PAPTQSEAEP QIVPLKGSET SFTPAVGLET LPLLKLADFG FARSLPATSL AETLCGSPLY 250 260 270 280 290 300 MAPEILRYEK YDAKADLWSV GTVLYEMVVG KPPFRATNHV ELLRKIETAR DRIKFPEENP 310 320 330 340 350 360 ASDDIKALVR GLLKFNPVVR MTFADFFEND IITGPIPGLA AEDVPIPDRP PSPEVIPTES 370 380 390 400 410 420 AEPQSVSDTI YPRNNDAEPK EDRYPPPHRY VPHNDRPQTP TSSSPMRRTR SGDRPSSAKQ 430 440 450 460 470 480 IPPAAAPPRP EAVSHATAPG RQELIGRHSS EQQAPGTVPV YKNVDKLKEE RELAAQEVAF 490 500 510 520 530 540 ERDYVVVEKR AVEVNAFADQ LAYDPRFHGK QTGALPRRQT TPALPTTQAS SQNSPRKAVQ 550 560 570 580 590 600 VVSGRSRADS AHNRHASYER RYGQSPTSAT SAISKALNMA SGRLFGVGFS PPLNIAKGGR 610 620 630 640 650 660 SPPLAYNPFP AYPTGHAGLL TMGDGARAQA SPDEDTRTVK ELEECATRSD VVYGFAEVKY 670 680 690 700 710 720 KQLIPLAPSS QSYNSPNAPG TNFEEGELTP DAAVTLSEEA LVLYVKALSL LAKSMDIAGA 730 740 750 760 770 780 WWMRKNRAEA LGESSFSRLE PVSIRINKVV QWVRSRFNEV LEKAEFVRLK LLEAQRRLPT 790 800 810 820 830 840 DHPSHPNNLS LESAGSGTSV DVMVSPGVTA EKLMYDRALE MSRAAAINEL TSEDLPGCEI 850 860 870 880 890 900 AYVTAIRMLE AVLETDEVQP SGKGTDKVTL DGVQGEEREV LLKLVSKIRM RLATLRQKLA 910 920 930 VLAKRQTPPS SGKMIPSNLA HATPATPATG MATPR

References

[1]

"Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae." Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H. , Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L., Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W. Nature 438:1105-1115(2005) [PubMed: 16372000] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FGSC 4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACD01000026 Genomic DNA. Translation: EAA64752.1.
RefSeq	XP_659236.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2874875.
KEGG	ani:AN1632.2.
Enzyme and pathway databases
BRENDA	2.7.11.1. 3859.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATG1_EMENI

Accession

Primary (citable) accession number: Q5BCU8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	April 26, 2005
Last modified:	June 16, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)