SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5BCI8

- MANBA_EMENI

UniProt

Q5BCI8 - MANBA_EMENI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Beta-mannosidase A
Gene
mndA, AN1742
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of beta-mannosidic oligosaccharides of various complexity and length. Involved in the degradation of polymeric mannan and galactomannan By similarity.

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei476 – 4761Proton donor By similarity

GO - Molecular functioni

  1. beta-mannosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00280.

Protein family/group databases

CAZyiGH2. Glycoside Hydrolase Family 2.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-mannosidase A (EC:3.2.1.25)
Alternative name(s):
Mannanase A
Short name:
Mannase A
Gene namesi
Name:mndA
ORF Names:AN1742
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome VII

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 940919Beta-mannosidase A
PRO_0000394649Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi15 – 151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi39 – 391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi79 – 791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi245 – 2451N-linked (GlcNAc...) Reviewed prediction
Glycosylationi314 – 3141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi321 – 3211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi344 – 3441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi534 – 5341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi605 – 6051N-linked (GlcNAc...) Reviewed prediction
Glycosylationi626 – 6261N-linked (GlcNAc...) Reviewed prediction
Glycosylationi653 – 6531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi733 – 7331N-linked (GlcNAc...) Reviewed prediction
Glycosylationi761 – 7611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi785 – 7851N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi162425.CADANIAP00008389.

Structurei

3D structure databases

ProteinModelPortaliQ5BCI8.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3250.
HOGENOMiHOG000216059.
KOiK01192.
OMAiCHATQLF.
OrthoDBiEOG78D7TH.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.320. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR008979. Galactose-bd-like.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR006102. Glyco_hydro_2_Ig-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00703. Glyco_hydro_2. 1 hit.
[Graphical view]
SUPFAMiSSF49303. SSF49303. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5BCI8-1 [UniParc]FASTAAdd to Basket

« Hide

MHFHGIATQA VLASNITTGS GRHVSLSDVK WTLSSSALNS TVPASLPSQA    50
HLDLLNAGVI DDPYYGLNEI DLQWIAQANW TYTSDPIPDL LEEYESTWLV 100
FEGLDTFATV TFCGHNIAST NNQFRQYAFD VSSALKECTG GPVVRIDFAS 150
APNTVDAIAA DPKTPVWPVQ LTAQLPNRWL MRKQQSDFGW DWGPAFAPCG 200
PWKPAYVVQL EKTAPIHVLN TDLDIYRQGN INHLPPDQKQ PWVVNASIDF 250
IGRLPAEPRL LIEIKELETG DVLASQISDS VTLIGTSITG VTTLKDASPK 300
LWWPSSLGAQ NLYNVTITVF NKTEEVARIT KRTGFRTIFL NQRNITATQL 350
SQGIAPGANW HFEVNGKEFY AKGSNFIPPD TFWPRVTKQK MTRLLDAVVA 400
GNQNMLRIWS SGAYLPDFIY DLADERGILL WSEFQFSDSM YPVDEDFLDN 450
VAQEVVYNVR RVNHHPSLAL WAGGNEIESL MLPLTREADP DNYPKYLAEY 500
EKLYISLILP LVYENTRSIS YSPSSTTEGY LSVNLSAPVP MTERYENDEP 550
GAYYGDTDYY NYDTTVSFDY SIYPVGRFAN EFGFHSMPSL QTWQQVADPE 600
DLYFNSTTVV IHNRHYTSEG YGRIENSSRG MAEMTLGVER YYPIPDNPDS 650
VANFSAWCLA TQLFQADFYK SQIQFYRRGS GMPERQLGSL YWQLEDIWQG 700
PTWAGIEYDG RWKVLHYVAR DVYQPIIVSP FWNYTTGDLE IYVTADLWES 750
AAGTVNLKWL NLSGEQIIDN AGTPTEIPFT VGAINTTKVY STNIHDLNLP 800
DTRASILTLS LSSQANLPNA AVKTSLTHEN HFTPSFPKDL ELVNPGLELS 850
YDAHSGIFTV EAKSGVSLYT WLDYPAGLVG YFTENAFLLV PGQKKKVQFV 900
VQDGPKDQDW EWQSEVTVRS LWDQKSSTFL YALRVATGRP 940
Length:940
Mass (Da):105,765
Last modified:April 26, 2005 - v1
Checksum:i45E1CBB33D2AFAF0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACD01000027 Genomic DNA. Translation: EAA64028.1.
BN001307 Genomic DNA. Translation: CBF85479.1.
RefSeqiXP_659346.1. XM_654254.1.

Genome annotation databases

EnsemblFungiiCADANIAT00008389; CADANIAP00008389; CADANIAG00008389.
GeneIDi2874889.
KEGGiani:AN1742.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACD01000027 Genomic DNA. Translation: EAA64028.1 .
BN001307 Genomic DNA. Translation: CBF85479.1 .
RefSeqi XP_659346.1. XM_654254.1.

3D structure databases

ProteinModelPortali Q5BCI8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 162425.CADANIAP00008389.

Protein family/group databases

CAZyi GH2. Glycoside Hydrolase Family 2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00008389 ; CADANIAP00008389 ; CADANIAG00008389 .
GeneIDi 2874889.
KEGGi ani:AN1742.2.

Phylogenomic databases

eggNOGi COG3250.
HOGENOMi HOG000216059.
KOi K01192.
OMAi CHATQLF.
OrthoDBi EOG78D7TH.

Enzyme and pathway databases

UniPathwayi UPA00280 .

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
2.60.40.320. 1 hit.
3.20.20.80. 2 hits.
InterProi IPR008979. Galactose-bd-like.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR006102. Glyco_hydro_2_Ig-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00703. Glyco_hydro_2. 1 hit.
[Graphical view ]
SUPFAMi SSF49303. SSF49303. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiMANBA_EMENI
AccessioniPrimary (citable) accession number: Q5BCI8
Secondary accession number(s): C8VP45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: April 26, 2005
Last modified: June 11, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi