Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Kynureninase 2

Gene

bna5-2

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Catalytic activityi

L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation
L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-kynurenine degradation

This protein is involved in step 1 of the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Kynureninase 1 (bna5-1), Kynureninase 2 (bna5-2)
This subpathway is part of the pathway L-kynurenine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine, the pathway L-kynurenine degradation and in Amino-acid degradation.

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Kynurenine 3-monooxygenase (bna4)
  2. Kynureninase 1 (bna5-1), Kynureninase 2 (bna5-2)
  3. 3-hydroxyanthranilate 3,4-dioxygenase (BNA1)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei144Pyridoxal phosphate; via amide nitrogenUniRule annotation1
Binding sitei145Pyridoxal phosphateUniRule annotation1
Binding sitei258Pyridoxal phosphateUniRule annotation1
Binding sitei261Pyridoxal phosphateUniRule annotation1
Binding sitei283Pyridoxal phosphateUniRule annotation1
Binding sitei323Pyridoxal phosphateUniRule annotation1
Binding sitei351Pyridoxal phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processPyridine nucleotide biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329
UPA00334; UER00455

Names & Taxonomyi

Protein namesi
Recommended name:
Kynureninase 2UniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
Biosynthesis of nicotinic acid protein 5-2UniRule annotation
L-kynurenine hydrolase 2UniRule annotation
Gene namesi
Name:bna5-2
ORF Names:AN1857
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome VII
  • UP000005890 Componenti: Unassembled WGS sequence

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003569781 – 474Kynureninase 2Add BLAST474

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei284N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ5BC73

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi162425.CADANIAP00008511

Structurei

3D structure databases

ProteinModelPortaliQ5BC73
SMRiQ5BC73
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni172 – 175Pyridoxal phosphate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000242438
InParanoidiQ5BC73
KOiK01556
OMAiGWYGGDK
OrthoDBiEOG092C20ON

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01970 Kynureninase, 1 hit
InterProiView protein in InterPro
IPR000192 Aminotrans_V_dom
IPR010111 Kynureninase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR14084 PTHR14084, 1 hit
PfamiView protein in Pfam
PF00266 Aminotran_5, 1 hit
PIRSFiPIRSF038800 KYNU, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01814 kynureninase, 1 hit

Sequencei

Sequence statusi: Complete.

Q5BC73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNHVNGVNG VNGVNGVKPV FPENAASKEY AKALDAADPL ASFRDKFIIP
60 70 80 90 100
SKANIQSKRL AKPNISADPC IYFCGNSLGL QPKATAKYME AHLDTWASIG
110 120 130 140 150
VNGHFTKIED SPLDPWWVMA EQAAGSMSKL VGAAPEEVIA MGTLTSNLHL
160 170 180 190 200
LLASFYKPTA TKHKILLDWK AFPSDHYAIE SHIAWHDGLD PKKSMVLIGP
210 220 230 240 250
DEGEYEIPTQ KILSIIDEHA DEAALILLPG IQYYTGQYFD INTITEYAHS
260 270 280 290 300
KGLMVGWDLA HAFANVELKL HEWDVDFAVW CTYKYANAGP GSMGGLFVHE
310 320 330 340 350
KHGKVDYSQG EDSPQFRHRL AGWYGGDRSV RFKMDNKFRP IPGAGGFQLS
360 370 380 390 400
TSSATDLTCL NASLSIFDQT SISELRRKSV QLTAYLEYLL LKDTTDETRP
410 420 430 440 450
FRIITPSNPE ERGAQLSLLL KPGLLQRVAD KLQSASIVCD KREPGVVRVA
460 470
PAPLYNTYSE VWQFVEQLKA AFQE
Length:474
Mass (Da):52,467
Last modified:November 16, 2011 - v2
Checksum:i12D43A644E6F499F
GO

Sequence cautioni

The sequence EAA65022 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000029 Genomic DNA Translation: EAA65022.1 Sequence problems.
BN001307 Genomic DNA Translation: CBF85703.1
RefSeqiXP_659461.1, XM_654369.1

Genome annotation databases

EnsemblFungiiCADANIAT00008511; CADANIAP00008511; CADANIAG00008511
EAA65022; EAA65022; AN1857.2
GeneIDi2875742
KEGGiani:AN1857.2

Similar proteinsi

Entry informationi

Entry nameiKYNU2_EMENI
AccessioniPrimary (citable) accession number: Q5BC73
Secondary accession number(s): C8VKF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: November 16, 2011
Last modified: May 23, 2018
This is version 74 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health