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Protein

RuvB-like helicase 1

Gene

rvb1

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi71 – 78ATPBy similarity8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Chromatin regulator, Helicase, Hydrolase
Biological processDNA damage, DNA repair, Transcription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RuvB-like helicase 1 (EC:3.6.4.12)
Gene namesi
Name:rvb1
ORF Names:AN1971
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome VII
  • UP000005890 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001656541 – 458RuvB-like helicase 1Add BLAST458

Interactioni

Subunit structurei

May form heterododecamers with RVB2. Component of the SWR1 chromatin remodeling complex, the INO80 chromatin remodeling complex, and of the R2TP complex (By similarity).By similarity

Protein-protein interaction databases

STRINGi162425.CADANIAP00008631

Structurei

3D structure databases

SMRiQ5BBV9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvB family.Curated

Phylogenomic databases

HOGENOMiHOG000190885
InParanoidiQ5BBV9
KOiK04499
OMAiDVHKRKE
OrthoDBiEOG092C2Z17

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR027417 P-loop_NTPase
IPR027238 RuvB-like
IPR037938 RUVBL1
IPR010339 TIP49_C
PANTHERiPTHR11093 PTHR11093, 1 hit
PTHR11093:SF6 PTHR11093:SF6, 1 hit
PfamiView protein in Pfam
PF06068 TIP49, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits

Sequencei

Sequence statusi: Complete.

Q5BBV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQISEVKGN SRDNRTAAHT HIKGLGLRPD GTAEVSGDGW VGQAAAREAC
60 70 80 90 100
GVVVDLIKAK KMAGRAVLLA GGPGTGKTAL ALAVSQELGT KVPFCPIVGS
110 120 130 140 150
EIYSAEVKKT EALMENFRRA IGLRVRETKE VYEGEVTELT PQEAENPLGG
160 170 180 190 200
YGRTISHLII GLKSAKGTKK LRLDPSIYEA IQKERVTVGD VIYIEANTGA
210 220 230 240 250
CKRVGRSDAY ATEFDLEAEE YVPVPKGEVH KKKEIVQDVT LHDLDIANAR
260 270 280 290 300
PQGGQDVMSM MGQLMKPKKT EITDKLRQEI NKVVNRYIDQ GVAELVPGVL
310 320 330 340 350
FIDEVHMLDI ECFTYLNRAL ESSISPIVIL ASNRGHTVIR GTDDISAAHG
360 370 380 390 400
IPPDLLARLL IIPTHPYSPD EIKTIIRLRA KTEGLNITDP ALDKVAEHGS
410 420 430 440 450
KVSLRYALQL LTPASILARV NGRPGGIEEA DVTECEDLFL DSKRSAAIVN

QDSEKFLY
Length:458
Mass (Da):49,830
Last modified:November 16, 2011 - v3
Checksum:iD0CF2416CB3FE397
GO

Sequence cautioni

The sequence EAA65136 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000029 Genomic DNA Translation: EAA65136.1 Sequence problems.
BN001307 Genomic DNA Translation: CBF85920.1
RefSeqiXP_659575.1, XM_654483.1

Genome annotation databases

EnsemblFungiiCADANIAT00008631; CADANIAP00008631; CADANIAG00008631
EAA65136; EAA65136; AN1971.2
GeneIDi2875269
KEGGiani:AN1971.2

Similar proteinsi

Entry informationi

Entry nameiRUVB1_EMENI
AccessioniPrimary (citable) accession number: Q5BBV9
Secondary accession number(s): C8VL43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: November 16, 2011
Last modified: March 28, 2018
This is version 89 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health