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Protein

Class E vacuolar protein-sorting machinery protein hse1

Gene

hse1

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).By similarity

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Class E vacuolar protein-sorting machinery protein hse1
Gene namesi
Name:hse1
ORF Names:AN2066
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome VII
  • UP000005890 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002924961 – 581Class E vacuolar protein-sorting machinery protein hse1Add BLAST581

Proteomic databases

PRIDEiQ5BBL4.

Interactioni

Subunit structurei

Component of the ESCRT-0 complex composed of HSE1 and VPS27.By similarity

Protein-protein interaction databases

STRINGi162425.CADANIAP00008735.

Structurei

3D structure databases

ProteinModelPortaliQ5BBL4.
SMRiQ5BBL4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 145VHSPROSITE-ProRule annotationAdd BLAST130
Domaini162 – 181UIMCuratedAdd BLAST20
Domaini215 – 274SH3PROSITE-ProRule annotationAdd BLAST60

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi372 – 576Pro-richAdd BLAST205

Sequence similaritiesi

Belongs to the STAM family.Curated

Keywords - Domaini

SH3 domain

Phylogenomic databases

HOGENOMiHOG000048362.
InParanoidiQ5BBL4.
KOiK04705.
OMAiMYAKLQS.
OrthoDBiEOG092C454D.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiView protein in InterPro
IPR008942. ENTH_VHS.
IPR004152. GAT_dom.
IPR036028. SH3-like_dom.
IPR001452. SH3_domain.
IPR002014. VHS_dom.
PfamiView protein in Pfam
PF03127. GAT. 1 hit.
PF00018. SH3_1. 1 hit.
PF00790. VHS. 1 hit.
PRINTSiPR00452. SH3DOMAIN.
SMARTiView protein in SMART
SM00326. SH3. 1 hit.
SM00288. VHS. 1 hit.
SUPFAMiSSF48464. SSF48464. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiView protein in PROSITE
PS50002. SH3. 1 hit.
PS50179. VHS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5BBL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRAQQNAFD DAVAKATDEN LTSENWEYIL DVCDKVGAEE SGAKDAVAAL
60 70 80 90 100
IKRLAHRNAN VQLYTLELAN ALAQNCGPKI HRELASRSFT DALLRLAGDR
110 120 130 140 150
NTHQQVKSKI LERMEDWTEM FASNPDFGIM EQAFMKLRTQ NPNLQPPSKP
160 170 180 190 200
GKREITDLDR QKEEEELQMA LALSIREKSG SAPQPQVESS SSVSAPENQA
210 220 230 240 250
QAAPAGPVPS GTSAATVSRV RALYDFQPSE PGELQFRKGD VIAVLESVYK
260 270 280 290 300
DWWKGSLRGQ TGIFPLNYVE KLPDPTVEEL QREAQMEAEV FGQIKNVEKL
310 320 330 340 350
LTLLSTRSSE LNVQENEEIT NLYNSTLSIR PKLVELIGKY SQKKDEFTQL
360 370 380 390 400
NEKFIKARRD YESLLEASMA QPPQQQFGRP GQPQYGYPGS GAPAGYPRGP
410 420 430 440 450
AQQHDPQRYF SPRPPDNQPN ASYYPPATQS PGPGHTSPPG PYQQQPQQPA
460 470 480 490 500
PDSYQPVHHR PESTYDQPQE LGTSVYDSPV ERLQYPPGPS GGQPHYQPPP
510 520 530 540 550
QQTPQPDFSA SSPNLVNQSQ SPYPATPVTQ PPPPTQQPPP VPGTASGSAP
560 570 580
YPSASPSAAN YQAYRPPQGG IPNHNPAAFY Q
Length:581
Mass (Da):64,069
Last modified:April 26, 2005 - v1
Checksum:iBDA595773D9754A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000032 Genomic DNA. Translation: EAA64898.1.
BN001307 Genomic DNA. Translation: CBF86109.1.
RefSeqiXP_659670.1. XM_654578.1.

Genome annotation databases

EnsemblFungiiCADANIAT00008735; CADANIAP00008735; CADANIAG00008735.
EAA64898; EAA64898; AN2066.2.
GeneIDi2875372.
KEGGiani:AN2066.2.

Similar proteinsi

Entry informationi

Entry nameiHSE1_EMENI
AccessioniPrimary (citable) accession number: Q5BBL4
Secondary accession number(s): C8VLP2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: April 26, 2005
Last modified: October 25, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families