Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Class E vacuolar protein-sorting machinery protein hse1

Gene

hse1

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Class E vacuolar protein-sorting machinery protein hse1
Gene namesi
Name:hse1
ORF Names:AN2066
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome VII
  • UP000005890 Componenti: Partially assembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:AN2066.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 581581Class E vacuolar protein-sorting machinery protein hse1PRO_0000292496Add
BLAST

Proteomic databases

PRIDEiQ5BBL4.

Interactioni

Subunit structurei

Component of the ESCRT-0 complex composed of HSE1 and VPS27.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5BBL4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 145130VHSPROSITE-ProRule annotationAdd
BLAST
Domaini162 – 18120UIMCuratedAdd
BLAST
Domaini215 – 27460SH3PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi372 – 576205Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the STAM family.Curated
Contains 1 SH3 domain.PROSITE-ProRule annotation
Contains 1 VHS domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

HOGENOMiHOG000048362.
InParanoidiQ5BBL4.
KOiK04705.
OMAiVMRRMGH.
OrthoDBiEOG75MW70.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiIPR008942. ENTH_VHS.
IPR004152. GAT_dom.
IPR001452. SH3_domain.
IPR013315. Spectrin_alpha_SH3.
IPR002014. VHS_dom.
[Graphical view]
PfamiPF03127. GAT. 1 hit.
PF00018. SH3_1. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
PR01887. SPECTRNALPHA.
SMARTiSM00326. SH3. 1 hit.
SM00288. VHS. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
PS50179. VHS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5BBL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRAQQNAFD DAVAKATDEN LTSENWEYIL DVCDKVGAEE SGAKDAVAAL
60 70 80 90 100
IKRLAHRNAN VQLYTLELAN ALAQNCGPKI HRELASRSFT DALLRLAGDR
110 120 130 140 150
NTHQQVKSKI LERMEDWTEM FASNPDFGIM EQAFMKLRTQ NPNLQPPSKP
160 170 180 190 200
GKREITDLDR QKEEEELQMA LALSIREKSG SAPQPQVESS SSVSAPENQA
210 220 230 240 250
QAAPAGPVPS GTSAATVSRV RALYDFQPSE PGELQFRKGD VIAVLESVYK
260 270 280 290 300
DWWKGSLRGQ TGIFPLNYVE KLPDPTVEEL QREAQMEAEV FGQIKNVEKL
310 320 330 340 350
LTLLSTRSSE LNVQENEEIT NLYNSTLSIR PKLVELIGKY SQKKDEFTQL
360 370 380 390 400
NEKFIKARRD YESLLEASMA QPPQQQFGRP GQPQYGYPGS GAPAGYPRGP
410 420 430 440 450
AQQHDPQRYF SPRPPDNQPN ASYYPPATQS PGPGHTSPPG PYQQQPQQPA
460 470 480 490 500
PDSYQPVHHR PESTYDQPQE LGTSVYDSPV ERLQYPPGPS GGQPHYQPPP
510 520 530 540 550
QQTPQPDFSA SSPNLVNQSQ SPYPATPVTQ PPPPTQQPPP VPGTASGSAP
560 570 580
YPSASPSAAN YQAYRPPQGG IPNHNPAAFY Q
Length:581
Mass (Da):64,069
Last modified:April 26, 2005 - v1
Checksum:iBDA595773D9754A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000032 Genomic DNA. Translation: EAA64898.1.
BN001307 Genomic DNA. Translation: CBF86109.1.
RefSeqiXP_659670.1. XM_654578.1.

Genome annotation databases

EnsemblFungiiCADANIAT00008735; CADANIAP00008735; CADANIAG00008735.
EAA64898; EAA64898; AN2066.2.
GeneIDi2875372.
KEGGiani:AN2066.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000032 Genomic DNA. Translation: EAA64898.1.
BN001307 Genomic DNA. Translation: CBF86109.1.
RefSeqiXP_659670.1. XM_654578.1.

3D structure databases

ProteinModelPortaliQ5BBL4.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ5BBL4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADANIAT00008735; CADANIAP00008735; CADANIAG00008735.
EAA64898; EAA64898; AN2066.2.
GeneIDi2875372.
KEGGiani:AN2066.2.

Organism-specific databases

EuPathDBiFungiDB:AN2066.

Phylogenomic databases

HOGENOMiHOG000048362.
InParanoidiQ5BBL4.
KOiK04705.
OMAiVMRRMGH.
OrthoDBiEOG75MW70.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiIPR008942. ENTH_VHS.
IPR004152. GAT_dom.
IPR001452. SH3_domain.
IPR013315. Spectrin_alpha_SH3.
IPR002014. VHS_dom.
[Graphical view]
PfamiPF03127. GAT. 1 hit.
PF00018. SH3_1. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
PR01887. SPECTRNALPHA.
SMARTiSM00326. SH3. 1 hit.
SM00288. VHS. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
PS50179. VHS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiHSE1_EMENI
AccessioniPrimary (citable) accession number: Q5BBL4
Secondary accession number(s): C8VLP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: April 26, 2005
Last modified: May 11, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.