Q5BB37 (CARA_EMENI) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 48.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Carbamoyl-phosphate synthase arginine-specific small chain Short name=CPS-A EC=6.3.5.5 Alternative name(s): Arginine-specific carbamoyl-phosphate synthetase, glutamine chain | ||||
| Gene names |
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| Organism | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) | ||||
| Taxonomic identifier | 227321 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › Emericella |
Protein attributes
| Sequence length | 454 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Catalytic activity | 2 ATP + L-glutamine + HCO3- + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate. |
| Pathway | Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1. |
| Subunit structure | Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate By similarity. |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the CarA family. Contains 1 glutamine amidotransferase type-1 domain. |
| Sequence caution | The sequence EAA63928.1 differs from that shown. Reason: Erroneous gene model prediction. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Arginine biosynthesis |
| Cellular component | Cytoplasm |
| Domain | Glutamine amidotransferase |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW glutamine metabolic processInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW carbamoyl-phosphate synthase (glutamine-hydrolyzing) activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 454 | 454 | Carbamoyl-phosphate synthase arginine-specific small chain | PRO_0000290595 | |||||
Regions | |||||||||
| Domain | 219 – 406 | 188 | Glutamine amidotransferase type-1 | ||||||
| Compositional bias | 443 – 454 | 12 | Poly-Ala | ||||||
Sites | |||||||||
| Active site | 295 | 1 | Nucleophile By similarity | ||||||
| Active site | 379 | 1 | By similarity | ||||||
| Active site | 381 | 1 | By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 14 | 1 | A → P in CAA11831. Ref.3 | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AACD01000036 Genomic DNA. Translation: EAA63928.1. Sequence problems. BN001307 Genomic DNA. Translation: CBF86449.1. AJ224085 mRNA. Translation: CAA11831.1. |
| RefSeq | XP_659847.1. XM_654755.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1CE8 based on UniProtKB P0A6F1. |
| ProteinModelPortal | Q5BB37. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q5BB37. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 2875485. |
| KEGG | ani:AN2243.2. |
Phylogenomic databases | |
| OrthoDB | EOG4N8VDH. |
| PhylomeDB | Q5BB37. |
Family and domain databases | |
| InterPro | IPR006274. CarbamoylP_synth_ssu. IPR002474. CarbamoylP_synth_ssu_N. IPR017926. GATASE_1. [Graphical view] |
| Gene3D | G3DSA:3.50.30.20. G3DSA:3.50.30.20. 1 hit. |
| KO | K01956. |
| Pfam | PF00988. CPSase_sm_chain. 1 hit. PF00117. GATase. 1 hit. [Graphical view] |
| SMART | SM01097. CPSase_sm_chain. 1 hit. [Graphical view] |
| SUPFAM | SSF52021. CP_synthsmall. 1 hit. |
| TIGRFAMs | TIGR01368. CPSaseIIsmall. 1 hit. |
| PROSITE | PS51273. GATASE_TYPE_1. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | CARA_EMENI | ||||||||
| Accession | Primary (citable) accession number: Q5BB37 Secondary accession number(s): C8VMT6, O42806 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with