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Q5BAP5

- EGLX_EMENI

UniProt

Q5BAP5 - EGLX_EMENI

Protein

Endo-1,3(4)-beta-glucanase xgeA

Gene

xgeA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Mixed-linked glucanase involved in the degradation of complex natural cellulosic substrates. Active on laminarin. lichenan, soluble carboxymethyl cellulose but not on pustulan.1 Publication

    Catalytic activityi

    Endohydrolysis of (1->3)- or (1->4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei142 – 1421NucleophileBy similarity
    Active sitei147 – 1471Proton donorBy similarity

    GO - Molecular functioni

    1. glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group Source: UniProtKB-EC
    2. glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group Source: UniProtKB-EC
    3. licheninase activity Source: UniProtKB

    GO - Biological processi

    1. cellulose catabolic process Source: UniProtKB-KW
    2. glucan catabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

    Protein family/group databases

    CAZyiGH16. Glycoside Hydrolase Family 16.
    mycoCLAPiMLG16A_EMENI.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endo-1,3(4)-beta-glucanase xgeA (EC:3.2.1.6)
    Alternative name(s):
    Mixed-linked glucanase xgeA
    Gene namesi
    Name:xgeA
    ORF Names:AN2385
    OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
    Taxonomic identifieri227321 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000000560: Chromosome VII

    Subcellular locationi

    Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 603578Endo-1,3(4)-beta-glucanase xgeAPRO_0000395093Add
    BLAST
    Propeptidei604 – 62623Removed in mature formSequence AnalysisPRO_0000395094Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi61 – 611N-linked (GlcNAc...)Sequence Analysis
    Lipidationi603 – 6031GPI-anchor amidated glycineSequence Analysis

    Keywords - PTMi

    Glycoprotein, GPI-anchor, Lipoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ5BAP5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi342 – 459118Thr-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 16 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000166269.
    OMAiSCVNYVA.
    OrthoDBiEOG7HB5KN.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000757. Glyco_hydro_16.
    [Graphical view]
    PfamiPF00722. Glyco_hydro_16. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5BAP5-1 [UniParc]FASTAAdd to Basket

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    MSSSLMRRVG SLAASAIIFP GIAHAASNYK LKESWEGEKI LNHFHFFDNA    50
    DPTNGFVTYV NQSYAESAGL VKTTDSGSLY LGVDYENVLT VDGPGRESVR 100
    IESNEYYDQG LYVVDIQHMP GSICGTWPAF WTVGPDWPTD GEIDIIEGVN 150
    KHDANKIVLH TSDTCDVGGG YKMTGDMTSS ECGEASGTIG CVVQGKQGSS 200
    GDPFNEQGGG VYAMEWQEKY LKIWYFPRSS IPESLTAGTP DVSSFGTPMA 250
    HLQGSCNFKE RFTHQKLILD TTFCGDWAGG VFGDSGCPVS DPSDPMLSCK 300
    NYVAENPAVY KNAYWELNSI KIYQLGGTAE VEGTQSAAAE STAAEATAAE 350
    TTAAATQTAN GGSIEEITTS THSVTRTKTV SATHSTETAA VTETAAATTA 400
    AASVASEVDA TNTQPVSKTK STSYVTSTTT LCPVESSQAA ATESVSRTKT 450
    TSYVTITTTL CPVESLQTAN AVPSAKASTD AAAATTPAAE PHPSNAETPA 500
    DSKSSADAVT AQATKTTIAV NTPNPATDSA SSVPPDSIVY TAPEVTSSSS 550
    VPLFTIVSSS SQFVTVPTAA PSSFEPTDAV RDGADSYSTA ASPTTPSNPV 600
    FTGVGSKVSI SASVAIAAFV MLLLVN 626
    Length:626
    Mass (Da):65,098
    Last modified:April 26, 2005 - v1
    Checksum:iB18C705CD41F4045
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACD01000039 Genomic DNA. Translation: EAA64496.1.
    BN001307 Genomic DNA. Translation: CBF86736.1.
    RefSeqiXP_659989.1. XM_654897.1.

    Genome annotation databases

    EnsemblFungiiCADANIAT00009087; CADANIAP00009087; CADANIAG00009087.
    GeneIDi2874796.
    KEGGiani:AN2385.2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACD01000039 Genomic DNA. Translation: EAA64496.1 .
    BN001307 Genomic DNA. Translation: CBF86736.1 .
    RefSeqi XP_659989.1. XM_654897.1.

    3D structure databases

    ProteinModelPortali Q5BAP5.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH16. Glycoside Hydrolase Family 16.
    mycoCLAPi MLG16A_EMENI.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADANIAT00009087 ; CADANIAP00009087 ; CADANIAG00009087 .
    GeneIDi 2874796.
    KEGGi ani:AN2385.2.

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000166269.
    OMAi SCVNYVA.
    OrthoDBi EOG7HB5KN.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000757. Glyco_hydro_16.
    [Graphical view ]
    Pfami PF00722. Glyco_hydro_16. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
    2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
      Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
      , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
      Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
    3. "Development and application of a suite of polysaccharide-degrading enzymes for analyzing plant cell walls."
      Bauer S., Vasu P., Persson S., Mort A.J., Somerville C.R.
      Proc. Natl. Acad. Sci. U.S.A. 103:11417-11422(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

    Entry informationi

    Entry nameiEGLX_EMENI
    AccessioniPrimary (citable) accession number: Q5BAP5
    Secondary accession number(s): C8VNP1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3