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Q5BAP5

- EGLX_EMENI

UniProt

Q5BAP5 - EGLX_EMENI

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Protein
Endo-1,3(4)-beta-glucanase xgeA
Gene
xgeA, AN2385
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Mixed-linked glucanase involved in the degradation of complex natural cellulosic substrates. Active on laminarin. lichenan, soluble carboxymethyl cellulose but not on pustulan.1 Publication

Catalytic activityi

Endohydrolysis of (1->3)- or (1->4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei142 – 1421Nucleophile By similarity
Active sitei147 – 1471Proton donor By similarity

GO - Molecular functioni

  1. glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group Source: UniProtKB-EC
  2. glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group Source: UniProtKB-EC
  3. licheninase activity Source: UniProtKB

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-KW
  2. glucan catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Protein family/group databases

CAZyiGH16. Glycoside Hydrolase Family 16.
mycoCLAPiMLG16A_EMENI.

Names & Taxonomyi

Protein namesi
Recommended name:
Endo-1,3(4)-beta-glucanase xgeA (EC:3.2.1.6)
Alternative name(s):
Mixed-linked glucanase xgeA
Gene namesi
Name:xgeA
ORF Names:AN2385
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome VII

Subcellular locationi

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Chaini26 – 603578Endo-1,3(4)-beta-glucanase xgeA
PRO_0000395093Add
BLAST
Propeptidei604 – 62623Removed in mature form Reviewed prediction
PRO_0000395094Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi61 – 611N-linked (GlcNAc...) Reviewed prediction
Lipidationi603 – 6031GPI-anchor amidated glycine Reviewed prediction

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Structurei

3D structure databases

ProteinModelPortaliQ5BAP5.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi342 – 459118Thr-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000166269.
OMAiSCVNYVA.
OrthoDBiEOG7HB5KN.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000757. Glyco_hydro_16.
[Graphical view]
PfamiPF00722. Glyco_hydro_16. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5BAP5-1 [UniParc]FASTAAdd to Basket

« Hide

MSSSLMRRVG SLAASAIIFP GIAHAASNYK LKESWEGEKI LNHFHFFDNA    50
DPTNGFVTYV NQSYAESAGL VKTTDSGSLY LGVDYENVLT VDGPGRESVR 100
IESNEYYDQG LYVVDIQHMP GSICGTWPAF WTVGPDWPTD GEIDIIEGVN 150
KHDANKIVLH TSDTCDVGGG YKMTGDMTSS ECGEASGTIG CVVQGKQGSS 200
GDPFNEQGGG VYAMEWQEKY LKIWYFPRSS IPESLTAGTP DVSSFGTPMA 250
HLQGSCNFKE RFTHQKLILD TTFCGDWAGG VFGDSGCPVS DPSDPMLSCK 300
NYVAENPAVY KNAYWELNSI KIYQLGGTAE VEGTQSAAAE STAAEATAAE 350
TTAAATQTAN GGSIEEITTS THSVTRTKTV SATHSTETAA VTETAAATTA 400
AASVASEVDA TNTQPVSKTK STSYVTSTTT LCPVESSQAA ATESVSRTKT 450
TSYVTITTTL CPVESLQTAN AVPSAKASTD AAAATTPAAE PHPSNAETPA 500
DSKSSADAVT AQATKTTIAV NTPNPATDSA SSVPPDSIVY TAPEVTSSSS 550
VPLFTIVSSS SQFVTVPTAA PSSFEPTDAV RDGADSYSTA ASPTTPSNPV 600
FTGVGSKVSI SASVAIAAFV MLLLVN 626
Length:626
Mass (Da):65,098
Last modified:April 26, 2005 - v1
Checksum:iB18C705CD41F4045
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACD01000039 Genomic DNA. Translation: EAA64496.1.
BN001307 Genomic DNA. Translation: CBF86736.1.
RefSeqiXP_659989.1. XM_654897.1.

Genome annotation databases

EnsemblFungiiCADANIAT00009087; CADANIAP00009087; CADANIAG00009087.
GeneIDi2874796.
KEGGiani:AN2385.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACD01000039 Genomic DNA. Translation: EAA64496.1 .
BN001307 Genomic DNA. Translation: CBF86736.1 .
RefSeqi XP_659989.1. XM_654897.1.

3D structure databases

ProteinModelPortali Q5BAP5.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH16. Glycoside Hydrolase Family 16.
mycoCLAPi MLG16A_EMENI.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00009087 ; CADANIAP00009087 ; CADANIAG00009087 .
GeneIDi 2874796.
KEGGi ani:AN2385.2.

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000166269.
OMAi SCVNYVA.
OrthoDBi EOG7HB5KN.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000757. Glyco_hydro_16.
[Graphical view ]
Pfami PF00722. Glyco_hydro_16. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  3. "Development and application of a suite of polysaccharide-degrading enzymes for analyzing plant cell walls."
    Bauer S., Vasu P., Persson S., Mort A.J., Somerville C.R.
    Proc. Natl. Acad. Sci. U.S.A. 103:11417-11422(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiEGLX_EMENI
AccessioniPrimary (citable) accession number: Q5BAP5
Secondary accession number(s): C8VNP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: April 26, 2005
Last modified: February 19, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi