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Q5BAE9

- NTE1_EMENI

UniProt

Q5BAE9 - NTE1_EMENI

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Protein

Lysophospholipase nte1

Gene

nte1

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1257 – 12571By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi682 – 809128cNMP 1Add
BLAST
Nucleotide bindingi846 – 966121cNMP 2Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
  2. phosphatidylcholine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase nte1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:nte1
ORF Names:AN2481
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome VII

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15271527Lysophospholipase nte1PRO_0000295320Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00009202.

Structurei

3D structure databases

ProteinModelPortaliQ5BAE9.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7373CytoplasmicBy similarityAdd
BLAST
Topological domaini95 – 11622LumenalBy similarityAdd
BLAST
Topological domaini138 – 15271390CytoplasmicBy similarityAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei74 – 9421HelicalSequence AnalysisAdd
BLAST
Transmembranei117 – 13721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1224 – 1388165PatatinAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1255 – 12595GXSXG

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi58 – 614Poly-Pro
Compositional biasi300 – 3067Poly-Ser

Sequence similaritiesi

Belongs to the NTE family.Curated
Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 patatin domain.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000048680.
InParanoidiQ5BAE9.
KOiK14676.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 5 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5BAE9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADSGASVPS PDLPDLDSLH ASLSLPDIPS VAATSLSTSL PAISAKVSGF
60 70 80 90 100
PSFSSHLPPP PLLSPPTPTT MVGWIGWVFS LVFQTIPSVL YWVITFSTIT
110 120 130 140 150
LPTWLFTLFS MSLTFTMNFT TLLLIVLGLV STVSWFIRYR FLNMYSRLPP
160 170 180 190 200
EPQRKEPQLD LFPDVQEGDS KPGLANYLDE FLSAIKVFGY LERPVFHELT
210 220 230 240 250
RTMQTRKLIA GETLQLEEEK GFCLVVDGLV QIFVKSMRSG KHGLNGEVIE
260 270 280 290 300
GSSDEDDQAR DGKQGYQLLT EVKNGASMSS LFSILSLFTE DIRLRASEGS
310 320 330 340 350
SSSMSSVQPS PARTTPAPFL DSPGEMLNGS PMVLPRDSEV DSSAINGEAE
360 370 380 390 400
PLPPVPPLHL GESRASSYHP NGQSTASERV RGNRRKSVHP DIVARAMVDT
410 420 430 440 450
TIAIIPASAF RRLTRLYPRA TAHIVQVILT RLQRVTFATA HSYLGLTNEV
460 470 480 490 500
LGIEKQMTKF TTYDLPNDIR GAALDRLKDK FLKEKDRLGS EEVTRGIALH
510 520 530 540 550
NPYAGRRRRS MSFVRKEAAL KAKMPLPKRP NSLINPERPF HGYDTAGVSP
560 570 580 590 600
GDLLSTIQLS RFGPRHDQFA TTPRLHSPLT EKERSPLRRS SLQRKDSVDE
610 620 630 640 650
DALFRESILD CIMKGIGLTP SSHNALRKGS HSGELSPKLV SYDSRRQKAV
660 670 680 690 700
FSNNAFGFID AYEGSGDGDT ESMMSMSVTS AGGTSPIVYL REDLLNDIEI
710 720 730 740 750
VYFPKGAVLV EQGERHPGLY YVIDGFLDVG VQVNEKGDDL VGASRPGHAQ
760 770 780 790 800
PDEELFPTLK RTQTATSRGA TAAAPINESK RKKPSRKSLY MIKPGGMQGY
810 820 830 840 850
VGAMASYRSY TDVVAKTDVY VGFLPRASLE RLAERYPIAL LTLAKRLTGL
860 870 880 890 900
LPRLLLHIDF ALEWVQVNAG QVIYHQGDES DAIYITLNGR LRSVHEGKGG
910 920 930 940 950
KMTVVGEHGQ GESVGELEVM TESTRPATLH AIRDTELAKF PRSLFNSLAQ
960 970 980 990 1000
EHTGITIQVS KLIAQRMRDL VENPMTEQGE PGNTGSVKTA TSTLNLRTVG
1010 1020 1030 1040 1050
ILPITTGVPV VEFGNRLLSA LQQIGVTDGV TSLNQAAILN HLGRHAFSRM
1060 1070 1080 1090 1100
GKLKLSQYLA DLEEKYGMVL YIADTNVNSP WTQTCISQAD CILLVGLAES
1110 1120 1130 1140 1150
SPNVGEYERF LLGMKTTARK ELVLLHADRY CPPGLTRKWL KNRVWINGGH
1160 1170 1180 1190 1200
HHIQMAFRLT AEPSHPQTKR LGTVLKQRVQ ILQAEIQKYT SRRIRQTPIY
1210 1220 1230 1240 1250
SAQTPFKGDF HRLARRLCGR AVGLVLGGGG ARGIAHVGVI KALEEAGIPV
1260 1270 1280 1290 1300
DIVGGTSIGA FIGGLYARDA DVVPMYGRAK KFAGRMGSIW RFALDLTYPS
1310 1320 1330 1340 1350
VSYTTGHEFN RGIFKTFGDS QIEDFWLEFY CNTTNISRSR AEYHSSGYVW
1360 1370 1380 1390 1400
RYVRASMSLA GLLPPICDEG SMLLDGGYID NLTVAHMKTL GADVIFAIDV
1410 1420 1430 1440 1450
GSIDDNTPQG YGDSLSGMWS VINRWNPFSS IPNPPTLSEI QARLAYVSSI
1460 1470 1480 1490 1500
DNLERAKNIP GCLYMRPPID RYGTLEFGNF DEIYQVGYAY GKEYLQKLKS
1510 1520
QGSLPLPEEN EEKKKLQRTL APRRASI
Length:1,527
Mass (Da):168,413
Last modified:July 24, 2007 - v2
Checksum:i27E5289D1C9A881A
GO

Sequence cautioni

The sequence CBF86943.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence EAA63799.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACD01000041 Genomic DNA. Translation: EAA63799.1. Sequence problems.
BN001307 Genomic DNA. Translation: CBF86943.1. Sequence problems.
RefSeqiXP_660085.1. XM_654993.1.

Genome annotation databases

EnsemblFungiiCADANIAT00009202; CADANIAP00009202; CADANIAG00009202.
GeneIDi2875190.
KEGGiani:AN2481.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACD01000041 Genomic DNA. Translation: EAA63799.1 . Sequence problems.
BN001307 Genomic DNA. Translation: CBF86943.1 . Sequence problems.
RefSeqi XP_660085.1. XM_654993.1.

3D structure databases

ProteinModelPortali Q5BAE9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 162425.CADANIAP00009202.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00009202 ; CADANIAP00009202 ; CADANIAG00009202 .
GeneIDi 2875190.
KEGGi ani:AN2481.2.

Phylogenomic databases

eggNOGi COG0664.
HOGENOMi HOG000048680.
InParanoidi Q5BAE9.
KOi K14676.
OrthoDBi EOG70W3NS.

Family and domain databases

Gene3Di 2.60.120.10. 5 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 2 hits.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiNTE1_EMENI
AccessioniPrimary (citable) accession number: Q5BAE9
Secondary accession number(s): C8VPA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: October 29, 2014
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3