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Q5BAE9

- NTE1_EMENI

UniProt

Q5BAE9 - NTE1_EMENI

Protein

Lysophospholipase nte1

Gene

nte1

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 2 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

    Enzyme regulationi

    Inhibited by organophosphorus esters.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei1257 – 12571By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi682 – 809128cNMP 1Add
    BLAST
    Nucleotide bindingi846 – 966121cNMP 2Add
    BLAST

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid catabolic process Source: UniProtKB-KW
    2. phosphatidylcholine metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysophospholipase nte1 (EC:3.1.1.5)
    Alternative name(s):
    Intracellular phospholipase B
    Neuropathy target esterase homolog
    Gene namesi
    Name:nte1
    ORF Names:AN2481
    OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
    Taxonomic identifieri227321 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000000560: Chromosome VII

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15271527Lysophospholipase nte1PRO_0000295320Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi162425.CADANIAP00009202.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5BAE9.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7373CytoplasmicBy similarityAdd
    BLAST
    Topological domaini95 – 11622LumenalBy similarityAdd
    BLAST
    Topological domaini138 – 15271390CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei74 – 9421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei117 – 13721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1224 – 1388165PatatinAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1255 – 12595GXSXG

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi58 – 614Poly-Pro
    Compositional biasi300 – 3067Poly-Ser

    Sequence similaritiesi

    Belongs to the NTE family.Curated
    Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
    Contains 1 patatin domain.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0664.
    HOGENOMiHOG000048680.
    KOiK14676.
    OrthoDBiEOG70W3NS.

    Family and domain databases

    Gene3Di2.60.120.10. 5 hits.
    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 2 hits.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 5 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5BAE9-1 [UniParc]FASTAAdd to Basket

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    MADSGASVPS PDLPDLDSLH ASLSLPDIPS VAATSLSTSL PAISAKVSGF     50
    PSFSSHLPPP PLLSPPTPTT MVGWIGWVFS LVFQTIPSVL YWVITFSTIT 100
    LPTWLFTLFS MSLTFTMNFT TLLLIVLGLV STVSWFIRYR FLNMYSRLPP 150
    EPQRKEPQLD LFPDVQEGDS KPGLANYLDE FLSAIKVFGY LERPVFHELT 200
    RTMQTRKLIA GETLQLEEEK GFCLVVDGLV QIFVKSMRSG KHGLNGEVIE 250
    GSSDEDDQAR DGKQGYQLLT EVKNGASMSS LFSILSLFTE DIRLRASEGS 300
    SSSMSSVQPS PARTTPAPFL DSPGEMLNGS PMVLPRDSEV DSSAINGEAE 350
    PLPPVPPLHL GESRASSYHP NGQSTASERV RGNRRKSVHP DIVARAMVDT 400
    TIAIIPASAF RRLTRLYPRA TAHIVQVILT RLQRVTFATA HSYLGLTNEV 450
    LGIEKQMTKF TTYDLPNDIR GAALDRLKDK FLKEKDRLGS EEVTRGIALH 500
    NPYAGRRRRS MSFVRKEAAL KAKMPLPKRP NSLINPERPF HGYDTAGVSP 550
    GDLLSTIQLS RFGPRHDQFA TTPRLHSPLT EKERSPLRRS SLQRKDSVDE 600
    DALFRESILD CIMKGIGLTP SSHNALRKGS HSGELSPKLV SYDSRRQKAV 650
    FSNNAFGFID AYEGSGDGDT ESMMSMSVTS AGGTSPIVYL REDLLNDIEI 700
    VYFPKGAVLV EQGERHPGLY YVIDGFLDVG VQVNEKGDDL VGASRPGHAQ 750
    PDEELFPTLK RTQTATSRGA TAAAPINESK RKKPSRKSLY MIKPGGMQGY 800
    VGAMASYRSY TDVVAKTDVY VGFLPRASLE RLAERYPIAL LTLAKRLTGL 850
    LPRLLLHIDF ALEWVQVNAG QVIYHQGDES DAIYITLNGR LRSVHEGKGG 900
    KMTVVGEHGQ GESVGELEVM TESTRPATLH AIRDTELAKF PRSLFNSLAQ 950
    EHTGITIQVS KLIAQRMRDL VENPMTEQGE PGNTGSVKTA TSTLNLRTVG 1000
    ILPITTGVPV VEFGNRLLSA LQQIGVTDGV TSLNQAAILN HLGRHAFSRM 1050
    GKLKLSQYLA DLEEKYGMVL YIADTNVNSP WTQTCISQAD CILLVGLAES 1100
    SPNVGEYERF LLGMKTTARK ELVLLHADRY CPPGLTRKWL KNRVWINGGH 1150
    HHIQMAFRLT AEPSHPQTKR LGTVLKQRVQ ILQAEIQKYT SRRIRQTPIY 1200
    SAQTPFKGDF HRLARRLCGR AVGLVLGGGG ARGIAHVGVI KALEEAGIPV 1250
    DIVGGTSIGA FIGGLYARDA DVVPMYGRAK KFAGRMGSIW RFALDLTYPS 1300
    VSYTTGHEFN RGIFKTFGDS QIEDFWLEFY CNTTNISRSR AEYHSSGYVW 1350
    RYVRASMSLA GLLPPICDEG SMLLDGGYID NLTVAHMKTL GADVIFAIDV 1400
    GSIDDNTPQG YGDSLSGMWS VINRWNPFSS IPNPPTLSEI QARLAYVSSI 1450
    DNLERAKNIP GCLYMRPPID RYGTLEFGNF DEIYQVGYAY GKEYLQKLKS 1500
    QGSLPLPEEN EEKKKLQRTL APRRASI 1527
    Length:1,527
    Mass (Da):168,413
    Last modified:July 24, 2007 - v2
    Checksum:i27E5289D1C9A881A
    GO

    Sequence cautioni

    The sequence CBF86943.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence EAA63799.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACD01000041 Genomic DNA. Translation: EAA63799.1. Sequence problems.
    BN001307 Genomic DNA. Translation: CBF86943.1. Sequence problems.
    RefSeqiXP_660085.1. XM_654993.1.

    Genome annotation databases

    EnsemblFungiiCADANIAT00009202; CADANIAP00009202; CADANIAG00009202.
    GeneIDi2875190.
    KEGGiani:AN2481.2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACD01000041 Genomic DNA. Translation: EAA63799.1 . Sequence problems.
    BN001307 Genomic DNA. Translation: CBF86943.1 . Sequence problems.
    RefSeqi XP_660085.1. XM_654993.1.

    3D structure databases

    ProteinModelPortali Q5BAE9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 162425.CADANIAP00009202.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADANIAT00009202 ; CADANIAP00009202 ; CADANIAG00009202 .
    GeneIDi 2875190.
    KEGGi ani:AN2481.2.

    Phylogenomic databases

    eggNOGi COG0664.
    HOGENOMi HOG000048680.
    KOi K14676.
    OrthoDBi EOG70W3NS.

    Family and domain databases

    Gene3Di 2.60.120.10. 5 hits.
    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 2 hits.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 5 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
    2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
      Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
      , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
      Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

    Entry informationi

    Entry nameiNTE1_EMENI
    AccessioniPrimary (citable) accession number: Q5BAE9
    Secondary accession number(s): C8VPA5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 70 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3