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Q5BAE9 (NTE1_EMENI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysophospholipase nte1

EC=3.1.1.5
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene names
Name:nte1
ORF Names:AN2481
OrganismEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) [Reference proteome]
Taxonomic identifier227321 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length1527 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulation

Inhibited by organophosphorus esters By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the NTE family.

Contains 2 cyclic nucleotide-binding domains.

Contains 1 patatin domain.

Sequence caution

The sequence CBF86943.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence EAA63799.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15271527Lysophospholipase nte1
PRO_0000295320

Regions

Topological domain1 – 7373Cytoplasmic By similarity
Transmembrane74 – 9421Helical; Potential
Topological domain95 – 11622Lumenal By similarity
Transmembrane117 – 13721Helical; Potential
Topological domain138 – 15271390Cytoplasmic By similarity
Domain1224 – 1388165Patatin
Nucleotide binding682 – 809128cNMP 1
Nucleotide binding846 – 966121cNMP 2
Motif1255 – 12595GXSXG
Compositional bias58 – 614Poly-Pro
Compositional bias300 – 3067Poly-Ser

Sites

Active site12571 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5BAE9 [UniParc].

Last modified July 24, 2007. Version 2.
Checksum: 27E5289D1C9A881A

FASTA1,527168,413
        10         20         30         40         50         60 
MADSGASVPS PDLPDLDSLH ASLSLPDIPS VAATSLSTSL PAISAKVSGF PSFSSHLPPP 

        70         80         90        100        110        120 
PLLSPPTPTT MVGWIGWVFS LVFQTIPSVL YWVITFSTIT LPTWLFTLFS MSLTFTMNFT 

       130        140        150        160        170        180 
TLLLIVLGLV STVSWFIRYR FLNMYSRLPP EPQRKEPQLD LFPDVQEGDS KPGLANYLDE 

       190        200        210        220        230        240 
FLSAIKVFGY LERPVFHELT RTMQTRKLIA GETLQLEEEK GFCLVVDGLV QIFVKSMRSG 

       250        260        270        280        290        300 
KHGLNGEVIE GSSDEDDQAR DGKQGYQLLT EVKNGASMSS LFSILSLFTE DIRLRASEGS 

       310        320        330        340        350        360 
SSSMSSVQPS PARTTPAPFL DSPGEMLNGS PMVLPRDSEV DSSAINGEAE PLPPVPPLHL 

       370        380        390        400        410        420 
GESRASSYHP NGQSTASERV RGNRRKSVHP DIVARAMVDT TIAIIPASAF RRLTRLYPRA 

       430        440        450        460        470        480 
TAHIVQVILT RLQRVTFATA HSYLGLTNEV LGIEKQMTKF TTYDLPNDIR GAALDRLKDK 

       490        500        510        520        530        540 
FLKEKDRLGS EEVTRGIALH NPYAGRRRRS MSFVRKEAAL KAKMPLPKRP NSLINPERPF 

       550        560        570        580        590        600 
HGYDTAGVSP GDLLSTIQLS RFGPRHDQFA TTPRLHSPLT EKERSPLRRS SLQRKDSVDE 

       610        620        630        640        650        660 
DALFRESILD CIMKGIGLTP SSHNALRKGS HSGELSPKLV SYDSRRQKAV FSNNAFGFID 

       670        680        690        700        710        720 
AYEGSGDGDT ESMMSMSVTS AGGTSPIVYL REDLLNDIEI VYFPKGAVLV EQGERHPGLY 

       730        740        750        760        770        780 
YVIDGFLDVG VQVNEKGDDL VGASRPGHAQ PDEELFPTLK RTQTATSRGA TAAAPINESK 

       790        800        810        820        830        840 
RKKPSRKSLY MIKPGGMQGY VGAMASYRSY TDVVAKTDVY VGFLPRASLE RLAERYPIAL 

       850        860        870        880        890        900 
LTLAKRLTGL LPRLLLHIDF ALEWVQVNAG QVIYHQGDES DAIYITLNGR LRSVHEGKGG 

       910        920        930        940        950        960 
KMTVVGEHGQ GESVGELEVM TESTRPATLH AIRDTELAKF PRSLFNSLAQ EHTGITIQVS 

       970        980        990       1000       1010       1020 
KLIAQRMRDL VENPMTEQGE PGNTGSVKTA TSTLNLRTVG ILPITTGVPV VEFGNRLLSA 

      1030       1040       1050       1060       1070       1080 
LQQIGVTDGV TSLNQAAILN HLGRHAFSRM GKLKLSQYLA DLEEKYGMVL YIADTNVNSP 

      1090       1100       1110       1120       1130       1140 
WTQTCISQAD CILLVGLAES SPNVGEYERF LLGMKTTARK ELVLLHADRY CPPGLTRKWL 

      1150       1160       1170       1180       1190       1200 
KNRVWINGGH HHIQMAFRLT AEPSHPQTKR LGTVLKQRVQ ILQAEIQKYT SRRIRQTPIY 

      1210       1220       1230       1240       1250       1260 
SAQTPFKGDF HRLARRLCGR AVGLVLGGGG ARGIAHVGVI KALEEAGIPV DIVGGTSIGA 

      1270       1280       1290       1300       1310       1320 
FIGGLYARDA DVVPMYGRAK KFAGRMGSIW RFALDLTYPS VSYTTGHEFN RGIFKTFGDS 

      1330       1340       1350       1360       1370       1380 
QIEDFWLEFY CNTTNISRSR AEYHSSGYVW RYVRASMSLA GLLPPICDEG SMLLDGGYID 

      1390       1400       1410       1420       1430       1440 
NLTVAHMKTL GADVIFAIDV GSIDDNTPQG YGDSLSGMWS VINRWNPFSS IPNPPTLSEI 

      1450       1460       1470       1480       1490       1500 
QARLAYVSSI DNLERAKNIP GCLYMRPPID RYGTLEFGNF DEIYQVGYAY GKEYLQKLKS 

      1510       1520 
QGSLPLPEEN EEKKKLQRTL APRRASI 

« Hide

References

« Hide 'large scale' references
[1]"Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae."
Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H. expand/collapse author list , Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L., Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.
Nature 438:1105-1115(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
[2]"The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G. expand/collapse author list , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACD01000041 Genomic DNA. Translation: EAA63799.1. Sequence problems.
BN001307 Genomic DNA. Translation: CBF86943.1. Sequence problems.
RefSeqXP_660085.1. XM_654993.1.

3D structure databases

ProteinModelPortalQ5BAE9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING162425.CADANIAP00009202.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADANIAT00009202; CADANIAP00009202; CADANIAG00009202.
GeneID2875190.
KEGGani:AN2481.2.

Phylogenomic databases

eggNOGCOG0664.
HOGENOMHOG000048680.
KOK14676.
OrthoDBEOG70W3NS.

Family and domain databases

Gene3D2.60.120.10. 5 hits.
InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNTE1_EMENI
AccessionPrimary (citable) accession number: Q5BAE9
Secondary accession number(s): C8VPA5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: April 16, 2014
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families