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Q5BAE9

- NTE1_EMENI

UniProt

Q5BAE9 - NTE1_EMENI

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Protein

Lysophospholipase nte1

Gene
nte1, AN2481
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1257 – 12571 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi682 – 809128cNMP 1Add
BLAST
Nucleotide bindingi846 – 966121cNMP 2Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
  2. phosphatidylcholine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase nte1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:nte1
ORF Names:AN2481
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome VII

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7373Cytoplasmic By similarityAdd
BLAST
Transmembranei74 – 9421Helical; Reviewed predictionAdd
BLAST
Topological domaini95 – 11622Lumenal By similarityAdd
BLAST
Transmembranei117 – 13721Helical; Reviewed predictionAdd
BLAST
Topological domaini138 – 15271390Cytoplasmic By similarityAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15271527Lysophospholipase nte1PRO_0000295320Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00009202.

Structurei

3D structure databases

ProteinModelPortaliQ5BAE9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1224 – 1388165PatatinAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1255 – 12595GXSXG

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi58 – 614Poly-Pro
Compositional biasi300 – 3067Poly-Ser

Sequence similaritiesi

Belongs to the NTE family.
Contains 1 patatin domain.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000048680.
KOiK14676.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 5 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5BAE9-1 [UniParc]FASTAAdd to Basket

« Hide

MADSGASVPS PDLPDLDSLH ASLSLPDIPS VAATSLSTSL PAISAKVSGF     50
PSFSSHLPPP PLLSPPTPTT MVGWIGWVFS LVFQTIPSVL YWVITFSTIT 100
LPTWLFTLFS MSLTFTMNFT TLLLIVLGLV STVSWFIRYR FLNMYSRLPP 150
EPQRKEPQLD LFPDVQEGDS KPGLANYLDE FLSAIKVFGY LERPVFHELT 200
RTMQTRKLIA GETLQLEEEK GFCLVVDGLV QIFVKSMRSG KHGLNGEVIE 250
GSSDEDDQAR DGKQGYQLLT EVKNGASMSS LFSILSLFTE DIRLRASEGS 300
SSSMSSVQPS PARTTPAPFL DSPGEMLNGS PMVLPRDSEV DSSAINGEAE 350
PLPPVPPLHL GESRASSYHP NGQSTASERV RGNRRKSVHP DIVARAMVDT 400
TIAIIPASAF RRLTRLYPRA TAHIVQVILT RLQRVTFATA HSYLGLTNEV 450
LGIEKQMTKF TTYDLPNDIR GAALDRLKDK FLKEKDRLGS EEVTRGIALH 500
NPYAGRRRRS MSFVRKEAAL KAKMPLPKRP NSLINPERPF HGYDTAGVSP 550
GDLLSTIQLS RFGPRHDQFA TTPRLHSPLT EKERSPLRRS SLQRKDSVDE 600
DALFRESILD CIMKGIGLTP SSHNALRKGS HSGELSPKLV SYDSRRQKAV 650
FSNNAFGFID AYEGSGDGDT ESMMSMSVTS AGGTSPIVYL REDLLNDIEI 700
VYFPKGAVLV EQGERHPGLY YVIDGFLDVG VQVNEKGDDL VGASRPGHAQ 750
PDEELFPTLK RTQTATSRGA TAAAPINESK RKKPSRKSLY MIKPGGMQGY 800
VGAMASYRSY TDVVAKTDVY VGFLPRASLE RLAERYPIAL LTLAKRLTGL 850
LPRLLLHIDF ALEWVQVNAG QVIYHQGDES DAIYITLNGR LRSVHEGKGG 900
KMTVVGEHGQ GESVGELEVM TESTRPATLH AIRDTELAKF PRSLFNSLAQ 950
EHTGITIQVS KLIAQRMRDL VENPMTEQGE PGNTGSVKTA TSTLNLRTVG 1000
ILPITTGVPV VEFGNRLLSA LQQIGVTDGV TSLNQAAILN HLGRHAFSRM 1050
GKLKLSQYLA DLEEKYGMVL YIADTNVNSP WTQTCISQAD CILLVGLAES 1100
SPNVGEYERF LLGMKTTARK ELVLLHADRY CPPGLTRKWL KNRVWINGGH 1150
HHIQMAFRLT AEPSHPQTKR LGTVLKQRVQ ILQAEIQKYT SRRIRQTPIY 1200
SAQTPFKGDF HRLARRLCGR AVGLVLGGGG ARGIAHVGVI KALEEAGIPV 1250
DIVGGTSIGA FIGGLYARDA DVVPMYGRAK KFAGRMGSIW RFALDLTYPS 1300
VSYTTGHEFN RGIFKTFGDS QIEDFWLEFY CNTTNISRSR AEYHSSGYVW 1350
RYVRASMSLA GLLPPICDEG SMLLDGGYID NLTVAHMKTL GADVIFAIDV 1400
GSIDDNTPQG YGDSLSGMWS VINRWNPFSS IPNPPTLSEI QARLAYVSSI 1450
DNLERAKNIP GCLYMRPPID RYGTLEFGNF DEIYQVGYAY GKEYLQKLKS 1500
QGSLPLPEEN EEKKKLQRTL APRRASI 1527
Length:1,527
Mass (Da):168,413
Last modified:July 24, 2007 - v2
Checksum:i27E5289D1C9A881A
GO

Sequence cautioni

The sequence CBF86943.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence EAA63799.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACD01000041 Genomic DNA. Translation: EAA63799.1. Sequence problems.
BN001307 Genomic DNA. Translation: CBF86943.1. Sequence problems.
RefSeqiXP_660085.1. XM_654993.1.

Genome annotation databases

EnsemblFungiiCADANIAT00009202; CADANIAP00009202; CADANIAG00009202.
GeneIDi2875190.
KEGGiani:AN2481.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACD01000041 Genomic DNA. Translation: EAA63799.1 . Sequence problems.
BN001307 Genomic DNA. Translation: CBF86943.1 . Sequence problems.
RefSeqi XP_660085.1. XM_654993.1.

3D structure databases

ProteinModelPortali Q5BAE9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 162425.CADANIAP00009202.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00009202 ; CADANIAP00009202 ; CADANIAG00009202 .
GeneIDi 2875190.
KEGGi ani:AN2481.2.

Phylogenomic databases

eggNOGi COG0664.
HOGENOMi HOG000048680.
KOi K14676.
OrthoDBi EOG70W3NS.

Family and domain databases

Gene3Di 2.60.120.10. 5 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 2 hits.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiNTE1_EMENI
AccessioniPrimary (citable) accession number: Q5BAE9
Secondary accession number(s): C8VPA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: April 16, 2014
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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