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Protein

Lysophospholipase nte1

Gene

nte1

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1257NucleophilePROSITE-ProRule annotation1
Active sitei1375Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi682 – 809cNMP 1Add BLAST128
Nucleotide bindingi846 – 966cNMP 2Add BLAST121

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase nte1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:nte1
ORF Names:AN2481
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome VII
  • UP000005890 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 73CytoplasmicBy similarityAdd BLAST73
Transmembranei74 – 94HelicalSequence analysisAdd BLAST21
Topological domaini95 – 116LumenalBy similarityAdd BLAST22
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Topological domaini138 – 1527CytoplasmicBy similarityAdd BLAST1390

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002953201 – 1527Lysophospholipase nte1Add BLAST1527

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00009202

Structurei

3D structure databases

ProteinModelPortaliQ5BAE9
SMRiQ5BAE9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1224 – 1388PNPLAPROSITE-ProRule annotationAdd BLAST165

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1228 – 1233GXGXXGPROSITE-ProRule annotation6
Motifi1255 – 1259GXSXGPROSITE-ProRule annotation5
Motifi1375 – 1377DGA/GPROSITE-ProRule annotation3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi58 – 61Poly-Pro4
Compositional biasi300 – 306Poly-Ser7

Sequence similaritiesi

Belongs to the NTE family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000048680
InParanoidiQ5BAE9
KOiK14676
OrthoDBiEOG092C0BAH

Family and domain databases

CDDicd00038 CAP_ED, 2 hits
Gene3Di2.60.120.101 hit
InterProiView protein in InterPro
IPR016035 Acyl_Trfase/lysoPLipase
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR001423 LysoPLipase_patatin_CS
IPR002641 PNPLA_dom
IPR014710 RmlC-like_jellyroll
PfamiView protein in Pfam
PF00027 cNMP_binding, 1 hit
PF01734 Patatin, 1 hit
SMARTiView protein in SMART
SM00100 cNMP, 2 hits
SUPFAMiSSF51206 SSF51206, 5 hits
SSF52151 SSF52151, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 2 hits
PS51635 PNPLA, 1 hit
PS01237 UPF0028, 1 hit

Sequencei

Sequence statusi: Complete.

Q5BAE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSGASVPS PDLPDLDSLH ASLSLPDIPS VAATSLSTSL PAISAKVSGF
60 70 80 90 100
PSFSSHLPPP PLLSPPTPTT MVGWIGWVFS LVFQTIPSVL YWVITFSTIT
110 120 130 140 150
LPTWLFTLFS MSLTFTMNFT TLLLIVLGLV STVSWFIRYR FLNMYSRLPP
160 170 180 190 200
EPQRKEPQLD LFPDVQEGDS KPGLANYLDE FLSAIKVFGY LERPVFHELT
210 220 230 240 250
RTMQTRKLIA GETLQLEEEK GFCLVVDGLV QIFVKSMRSG KHGLNGEVIE
260 270 280 290 300
GSSDEDDQAR DGKQGYQLLT EVKNGASMSS LFSILSLFTE DIRLRASEGS
310 320 330 340 350
SSSMSSVQPS PARTTPAPFL DSPGEMLNGS PMVLPRDSEV DSSAINGEAE
360 370 380 390 400
PLPPVPPLHL GESRASSYHP NGQSTASERV RGNRRKSVHP DIVARAMVDT
410 420 430 440 450
TIAIIPASAF RRLTRLYPRA TAHIVQVILT RLQRVTFATA HSYLGLTNEV
460 470 480 490 500
LGIEKQMTKF TTYDLPNDIR GAALDRLKDK FLKEKDRLGS EEVTRGIALH
510 520 530 540 550
NPYAGRRRRS MSFVRKEAAL KAKMPLPKRP NSLINPERPF HGYDTAGVSP
560 570 580 590 600
GDLLSTIQLS RFGPRHDQFA TTPRLHSPLT EKERSPLRRS SLQRKDSVDE
610 620 630 640 650
DALFRESILD CIMKGIGLTP SSHNALRKGS HSGELSPKLV SYDSRRQKAV
660 670 680 690 700
FSNNAFGFID AYEGSGDGDT ESMMSMSVTS AGGTSPIVYL REDLLNDIEI
710 720 730 740 750
VYFPKGAVLV EQGERHPGLY YVIDGFLDVG VQVNEKGDDL VGASRPGHAQ
760 770 780 790 800
PDEELFPTLK RTQTATSRGA TAAAPINESK RKKPSRKSLY MIKPGGMQGY
810 820 830 840 850
VGAMASYRSY TDVVAKTDVY VGFLPRASLE RLAERYPIAL LTLAKRLTGL
860 870 880 890 900
LPRLLLHIDF ALEWVQVNAG QVIYHQGDES DAIYITLNGR LRSVHEGKGG
910 920 930 940 950
KMTVVGEHGQ GESVGELEVM TESTRPATLH AIRDTELAKF PRSLFNSLAQ
960 970 980 990 1000
EHTGITIQVS KLIAQRMRDL VENPMTEQGE PGNTGSVKTA TSTLNLRTVG
1010 1020 1030 1040 1050
ILPITTGVPV VEFGNRLLSA LQQIGVTDGV TSLNQAAILN HLGRHAFSRM
1060 1070 1080 1090 1100
GKLKLSQYLA DLEEKYGMVL YIADTNVNSP WTQTCISQAD CILLVGLAES
1110 1120 1130 1140 1150
SPNVGEYERF LLGMKTTARK ELVLLHADRY CPPGLTRKWL KNRVWINGGH
1160 1170 1180 1190 1200
HHIQMAFRLT AEPSHPQTKR LGTVLKQRVQ ILQAEIQKYT SRRIRQTPIY
1210 1220 1230 1240 1250
SAQTPFKGDF HRLARRLCGR AVGLVLGGGG ARGIAHVGVI KALEEAGIPV
1260 1270 1280 1290 1300
DIVGGTSIGA FIGGLYARDA DVVPMYGRAK KFAGRMGSIW RFALDLTYPS
1310 1320 1330 1340 1350
VSYTTGHEFN RGIFKTFGDS QIEDFWLEFY CNTTNISRSR AEYHSSGYVW
1360 1370 1380 1390 1400
RYVRASMSLA GLLPPICDEG SMLLDGGYID NLTVAHMKTL GADVIFAIDV
1410 1420 1430 1440 1450
GSIDDNTPQG YGDSLSGMWS VINRWNPFSS IPNPPTLSEI QARLAYVSSI
1460 1470 1480 1490 1500
DNLERAKNIP GCLYMRPPID RYGTLEFGNF DEIYQVGYAY GKEYLQKLKS
1510 1520
QGSLPLPEEN EEKKKLQRTL APRRASI
Length:1,527
Mass (Da):168,413
Last modified:July 24, 2007 - v2
Checksum:i27E5289D1C9A881A
GO

Sequence cautioni

The sequence CBF86943 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAA63799 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000041 Genomic DNA Translation: EAA63799.1 Sequence problems.
BN001307 Genomic DNA Translation: CBF86943.1 Sequence problems.
RefSeqiXP_660085.1, XM_654993.1

Genome annotation databases

EnsemblFungiiCADANIAT00009202; CADANIAP00009202; CADANIAG00009202
EAA63799; EAA63799; AN2481.2
GeneIDi2875190
KEGGiani:AN2481.2

Similar proteinsi

Entry informationi

Entry nameiNTE1_EMENI
AccessioniPrimary (citable) accession number: Q5BAE9
Secondary accession number(s): C8VPA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: February 28, 2018
This is version 88 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome