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Protein

Rhamnogalacturonan acetylesterase

Gene

AN2528

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a key role in the degradation of rhamnogalacturonan in the cell wall. Involved in degradation of pectin.2 Publications

Catalytic activityi

Hydrolytic cleavage of 2-O-acetyl- or 3-O-acetyl groups of alpha-D-galacturonic acid in rhamnogalacturonan I.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei26 – 261NucleophileBy similarity
Active sitei204 – 2041By similarity
Active sitei207 – 2071By similarity

GO - Molecular functioni

  • rhamnogalacturonan acetylesterase activity Source: UniProtKB

GO - Biological processi

  • pectin catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Protein family/group databases

mycoCLAPiRAE12A_EMENI.

Names & Taxonomyi

Protein namesi
Recommended name:
Rhamnogalacturonan acetylesterase1 Publication (EC:3.1.1.861 Publication)
Short name:
RGAE
Gene namesi
ORF Names:AN2528
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome VII
  • UP000005890 Componenti: Partially assembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:AN2528.

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 245228Rhamnogalacturonan acetylesterasePRO_0000432721Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi100 ↔ 108By similarity
Disulfide bondi226 ↔ 244By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliQ5BAA2.
SMRiQ5BAA2. Positions 19-245.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 'GDSL' lipolytic enzyme family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000199666.
KOiK15530.
OMAiYFPNDHT.
OrthoDBiEOG092C4HKG.

Family and domain databases

Gene3Di3.40.50.1110. 1 hit.
InterProiIPR013830. SGNH_hydro.
[Graphical view]
PfamiPF13472. Lipase_GDSL_2. 1 hit.
[Graphical view]
SUPFAMiSSF52266. SSF52266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5BAA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSIALTSLS LLPSALAQTI YLAGDSTMAS STPGWGDYIA DSVSVEISNQ
60 70 80 90 100
AIGGRSARSY TREGRFQAIA DVLQAGDYVV IEFGHNDGGS LSNDNGRTDC
110 120 130 140 150
PGDGDETCET VYNGVAETVL TFPAYIENAA LLFLEKGANV LISSQTPNNP
160 170 180 190 200
WESGTFSYTP NRFVGYAELA AQRAGVDYVD HGAYTASIFE ALGADTVNSF
210 220 230 240
YPNDHTHTNA EGSSVVADAF LKAVVCSGVA LNDVLTRTDF DGECL
Length:245
Mass (Da):25,870
Last modified:April 26, 2005 - v1
Checksum:iE0D993BAC02EBACD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BN001307 Genomic DNA. Translation: CBF87034.1.
AACD01000043 Genomic DNA. Translation: EAA64633.1.
RefSeqiXP_660132.1. XM_655040.1.

Genome annotation databases

EnsemblFungiiCADANIAT00009256; CADANIAP00009256; CADANIAG00009256.
EAA64633; EAA64633; AN2528.2.
GeneIDi2874587.
KEGGiani:AN2528.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BN001307 Genomic DNA. Translation: CBF87034.1.
AACD01000043 Genomic DNA. Translation: EAA64633.1.
RefSeqiXP_660132.1. XM_655040.1.

3D structure databases

ProteinModelPortaliQ5BAA2.
SMRiQ5BAA2. Positions 19-245.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

mycoCLAPiRAE12A_EMENI.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADANIAT00009256; CADANIAP00009256; CADANIAG00009256.
EAA64633; EAA64633; AN2528.2.
GeneIDi2874587.
KEGGiani:AN2528.2.

Organism-specific databases

EuPathDBiFungiDB:AN2528.

Phylogenomic databases

HOGENOMiHOG000199666.
KOiK15530.
OMAiYFPNDHT.
OrthoDBiEOG092C4HKG.

Family and domain databases

Gene3Di3.40.50.1110. 1 hit.
InterProiIPR013830. SGNH_hydro.
[Graphical view]
PfamiPF13472. Lipase_GDSL_2. 1 hit.
[Graphical view]
SUPFAMiSSF52266. SSF52266. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRHA1_EMENI
AccessioniPrimary (citable) accession number: Q5BAA2
Secondary accession number(s): C8VPL0, Q1HFU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 2015
Last sequence update: April 26, 2005
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.