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Q5BA18 (BGLK_EMENI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable beta-glucosidase K

EC=3.2.1.21
Alternative name(s):
Beta-D-glucoside glucohydrolase K
Cellobiase K
Gentiobiase K
Gene names
Name:bglK
ORF Names:AN2612
OrganismEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) [Reference proteome]
Taxonomic identifier227321 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length838 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose By similarity.

Catalytic activity

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathway

Glycan metabolism; cellulose degradation.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 3 family.

Contains 1 PA14 domain.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Cellulose degradation
Polysaccharide degradation
   Cellular componentSecreted
   Molecular functionGlycosidase
Hydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellulose catabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbeta-glucosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 838838Probable beta-glucosidase K
PRO_0000394898

Regions

Domain406 – 553148PA14

Sites

Active site2321 By similarity

Amino acid modifications

Glycosylation191N-linked (GlcNAc...) Potential
Glycosylation3241N-linked (GlcNAc...) Potential
Glycosylation4891N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q5BA18 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: D69D1188267FB44C

FASTA83891,126
        10         20         30         40         50         60 
MGEISPRGGD FDIDYILENA SSLEKISLLA GHDFWHTAPL PRFNVPSVRV SDGPNGVRGT 

        70         80         90        100        110        120 
KFFDGVRAAC LPCGTGLAAT WDQSLLFDAG VLIGQECLAK GAHCWLGPTV CIQRSPLGGR 

       130        140        150        160        170        180 
GFESFAEDPY ATGKLAAAYI RGAQSTGVIS TIKHFAANDQ EHERISVNAV MSERALREVH 

       190        200        210        220        230        240 
LLPFQIAIAD AAPGAVMTCY NKINGQHVSE SKEMLDGLLR KEWGWKGLIM SDWFGTYSTA 

       250        260        270        280        290        300 
EALNAGLDLE MPGPTRLRGP LLELAISSRK VSRSTLDERA RTVLEFVKRA NKAEVSTVES 

       310        320        330        340        350        360 
TRDFPEDRRL NRKLAADSIV LLKNESGLLP LNLKALKSAA LIGPNMKTAA FCGGGSASLQ 

       370        380        390        400        410        420 
PYYSISPYQG IMNQLPPGVE IIYETGASSY VFIPELEASE VRTPEGQPGL RMRFYREPPS 

       430        440        450        460        470        480 
VKERRVVEET ILQESSWQLM GFSNPQLDRL FYADIEAELI APATGPFEFG LAVYGSGSLF 

       490        500        510        520        530        540 
IDDQLIIDNT TVQRGGNFFF GKGTREEKAT VDLVKGQLYK IRVEFASGPS SKLMKPGVVN 

       550        560        570        580        590        600 
FGGGAGRLGM VQAIDPELAI ARAVEAAKRA DVTILGVGLT RDHESEGFDR SHMDLPPAVA 

       610        620        630        640        650        660 
SLVTAVLDVA PDAILMTQSG TPFNMLPWAD NVKTHLHAWF GGNELGNGIA DVLFGVVNPS 

       670        680        690        700        710        720 
GKLPLSFPRR IEDTPTYLNF GSERGQVTYG EGIYVGYRYY EKVLRDVLYP FGHGLSYTSF 

       730        740        750        760        770        780 
AYSDFAVDTA SATLNVRNSG DVAGAEVVQL YIAADATTSS IARPVKELKG FAKVTLQPGE 

       790        800        810        820        830 
TCSVSIPFDR FTTAFWDQEA HVWTCEKGQY RVMVGSSSQN ILLEGVLEIK ETTTWSGL 

« Hide

References

« Hide 'large scale' references
[1]"Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae."
Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H. expand/collapse author list , Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L., Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.
Nature 438:1105-1115(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
[2]"The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G. expand/collapse author list , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ490481 mRNA. Translation: ABF50857.1.
AACD01000043 Genomic DNA. Translation: EAA64717.1.
BN001307 Genomic DNA. Translation: CBF87201.1.
RefSeqXP_660216.1. XM_655124.1.

3D structure databases

ProteinModelPortalQ5BA18.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH3. Glycoside Hydrolase Family 3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADANIAT00009350; CADANIAP00009350; CADANIAG00009350.
GeneID2874655.
KEGGani:AN2612.2.

Phylogenomic databases

eggNOGCOG1472.
HOGENOMHOG000031215.
OMARELHRDN.
OrthoDBEOG7H799Q.

Enzyme and pathway databases

UniPathwayUPA00696.

Family and domain databases

Gene3D3.20.20.300. 1 hit.
3.40.50.1700. 2 hits.
InterProIPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR019800. Glyco_hydro_3_AS.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
IPR011658. PA14.
[Graphical view]
PANTHERPTHR30620. PTHR30620. 1 hit.
PfamPF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
PF07691. PA14. 1 hit.
[Graphical view]
PRINTSPR00133. GLHYDRLASE3.
SMARTSM00758. PA14. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.
PROSITEPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBGLK_EMENI
AccessionPrimary (citable) accession number: Q5BA18
Secondary accession number(s): C8VKN4, Q1HFU3
Entry history
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: April 26, 2005
Last modified: January 22, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries