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Protein

Mannitol 2-dehydrogenase

Gene

AN2815

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway.By similarity

Catalytic activityi

D-mannitol + NAD+ = D-fructose + NADH.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi37 – 48NADBy similarityAdd BLAST12

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Mannitol 2-dehydrogenase (EC:1.1.1.67)
Short name:
M2DH
Short name:
MDH
Gene namesi
ORF Names:AN2815
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome VI
  • UP000005890 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003715441 – 502Mannitol 2-dehydrogenaseAdd BLAST502

Proteomic databases

PRIDEiQ5B9G5

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi162425.CADANIAP00010285

Structurei

3D structure databases

SMRiQ5B9G5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mannitol dehydrogenase family.Curated

Phylogenomic databases

HOGENOMiHOG000202982
InParanoidiQ5B9G5
KOiK00045
OMAiEDSFPNG
OrthoDBiEOG092C1JOH

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR000669 Mannitol_DH
IPR013118 Mannitol_DH_C
IPR013131 Mannitol_DH_N
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF01232 Mannitol_dh, 1 hit
PF08125 Mannitol_dh_C, 1 hit
PRINTSiPR00084 MTLDHDRGNASE
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

Q5B9G5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPLKLNSKN LAAILNAGKG QIKVPTYPRN GAVKEGIVHI GVGGFHRAHL
60 70 80 90 100
AVYIDRLMQN HGVTDYAIAG VGLTPFDKKM RDILRSQDHL YTVIERSAKG
110 120 130 140 150
SFANVVGSIN SFLFAPDDRE AVVAKMAHPD THIVSLTITE SGYYYNENTH
160 170 180 190 200
ELVSEHPDIQ FDLDPANEKT PRTTFGFLYA ALARRFKQGL NPFTVMSCDN
210 220 230 240 250
MQKNGAITRH MLESFARLRN PEIAEWISKK GHFPNAMVDR ITPQTAPADI
260 270 280 290 300
TALANDFGIQ DDWPVVTEPF MDWVIEDHFC DGRPPFEKVG VKVVKDLRAV
310 320 330 340 350
EEYEKHKLRL LNGSHSAIGY AGQLAGFQYV HEVLQNDTYK KFLWQMMQEE
360 370 380 390 400
VKPLLPEIPG VDIDEYCRTL IERFSNPTIK DQLPRICLNA SGKIPQFIMP
410 420 430 440 450
SIAEAIWVTG PFRRLCFVAA AWFRYLHGVD DAGNKFDIED PMLEELQAKA
460 470 480 490 500
KAGGLEPHEI LSIKSLFGDD LRGDKRFLQE ITTAMQLIDR DGVLKTMPKY

VD
Length:502
Mass (Da):56,583
Last modified:November 16, 2011 - v2
Checksum:i8350C8EF792FCDEF
GO

Sequence cautioni

The sequence EAA62921 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000050 Genomic DNA Translation: EAA62921.1 Sequence problems.
BN001306 Genomic DNA Translation: CBF83955.1
RefSeqiXP_660419.1, XM_655327.1

Genome annotation databases

EnsemblFungiiCADANIAT00010285; CADANIAP00010285; CADANIAG00010285
EAA62921; EAA62921; AN2815.2
GeneIDi2874179
KEGGiani:AN2815.2

Similar proteinsi

Entry informationi

Entry nameiM2DH_EMENI
AccessioniPrimary (citable) accession number: Q5B9G5
Secondary accession number(s): C8VJH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: November 16, 2011
Last modified: May 23, 2018
This is version 84 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health