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Q5B9G5

- M2DH_EMENI

UniProt

Q5B9G5 - M2DH_EMENI

Protein

Mannitol 2-dehydrogenase

Gene

AN2815

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 2 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway.By similarity

    Catalytic activityi

    D-mannitol + NAD+ = D-fructose + NADH.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi37 – 4812NADBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. coenzyme binding Source: InterPro
    2. mannitol 2-dehydrogenase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mannitol 2-dehydrogenase (EC:1.1.1.67)
    Short name:
    M2DH
    Short name:
    MDH
    Gene namesi
    ORF Names:AN2815
    OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
    Taxonomic identifieri227321 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000000560: Chromosome VI

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 502502Mannitol 2-dehydrogenasePRO_0000371544Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi162425.CADANIAP00010285.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the mannitol dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG0246.
    HOGENOMiHOG000202982.
    KOiK00045.
    OMAiWLHFVRR.
    OrthoDBiEOG7PCJRT.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR000669. Mannitol_DH.
    IPR013118. Mannitol_DH_C.
    IPR013131. Mannitol_DH_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF01232. Mannitol_dh. 1 hit.
    PF08125. Mannitol_dh_C. 1 hit.
    [Graphical view]
    PRINTSiPR00084. MTLDHDRGNASE.
    SUPFAMiSSF48179. SSF48179. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5B9G5-1 [UniParc]FASTAAdd to Basket

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    MPPLKLNSKN LAAILNAGKG QIKVPTYPRN GAVKEGIVHI GVGGFHRAHL    50
    AVYIDRLMQN HGVTDYAIAG VGLTPFDKKM RDILRSQDHL YTVIERSAKG 100
    SFANVVGSIN SFLFAPDDRE AVVAKMAHPD THIVSLTITE SGYYYNENTH 150
    ELVSEHPDIQ FDLDPANEKT PRTTFGFLYA ALARRFKQGL NPFTVMSCDN 200
    MQKNGAITRH MLESFARLRN PEIAEWISKK GHFPNAMVDR ITPQTAPADI 250
    TALANDFGIQ DDWPVVTEPF MDWVIEDHFC DGRPPFEKVG VKVVKDLRAV 300
    EEYEKHKLRL LNGSHSAIGY AGQLAGFQYV HEVLQNDTYK KFLWQMMQEE 350
    VKPLLPEIPG VDIDEYCRTL IERFSNPTIK DQLPRICLNA SGKIPQFIMP 400
    SIAEAIWVTG PFRRLCFVAA AWFRYLHGVD DAGNKFDIED PMLEELQAKA 450
    KAGGLEPHEI LSIKSLFGDD LRGDKRFLQE ITTAMQLIDR DGVLKTMPKY 500
    VD 502
    Length:502
    Mass (Da):56,583
    Last modified:November 16, 2011 - v2
    Checksum:i8350C8EF792FCDEF
    GO

    Sequence cautioni

    The sequence EAA62921.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACD01000050 Genomic DNA. Translation: EAA62921.1. Sequence problems.
    BN001306 Genomic DNA. Translation: CBF83955.1.
    RefSeqiXP_660419.1. XM_655327.1.

    Genome annotation databases

    EnsemblFungiiCADANIAT00010285; CADANIAP00010285; CADANIAG00010285.
    GeneIDi2874179.
    KEGGiani:AN2815.2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACD01000050 Genomic DNA. Translation: EAA62921.1 . Sequence problems.
    BN001306 Genomic DNA. Translation: CBF83955.1 .
    RefSeqi XP_660419.1. XM_655327.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 162425.CADANIAP00010285.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADANIAT00010285 ; CADANIAP00010285 ; CADANIAG00010285 .
    GeneIDi 2874179.
    KEGGi ani:AN2815.2.

    Phylogenomic databases

    eggNOGi COG0246.
    HOGENOMi HOG000202982.
    KOi K00045.
    OMAi WLHFVRR.
    OrthoDBi EOG7PCJRT.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR000669. Mannitol_DH.
    IPR013118. Mannitol_DH_C.
    IPR013131. Mannitol_DH_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF01232. Mannitol_dh. 1 hit.
    PF08125. Mannitol_dh_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00084. MTLDHDRGNASE.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
    2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
      Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
      , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
      Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

    Entry informationi

    Entry nameiM2DH_EMENI
    AccessioniPrimary (citable) accession number: Q5B9G5
    Secondary accession number(s): C8VJH9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 65 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3