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Q5B934

- DAPB_EMENI

UniProt

Q5B934 - DAPB_EMENI

Protein

Probable dipeptidyl-aminopeptidase B

Gene

dapB

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei743 – 7431Charge relay systemBy similarity
    Active sitei820 – 8201Charge relay systemBy similarity
    Active sitei853 – 8531Charge relay systemBy similarity

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. serine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS09.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
    Short name:
    DPAP B
    Gene namesi
    Name:dapB
    Synonyms:ste13
    ORF Names:AN2946
    OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
    Taxonomic identifieri227321 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000000560: Chromosome VI

    Subcellular locationi

    Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
    Note: Lysosome-like vacuoles.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. vacuolar membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 906906Probable dipeptidyl-aminopeptidase BPRO_0000412145Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi338 – 3381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi629 – 6291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi797 – 7971N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi162425.CADANIAP00010138.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5B934.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 8585CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini107 – 906800VacuolarSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei86 – 10621Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi403 – 4097Poly-Asp

    Sequence similaritiesi

    Belongs to the peptidase S9B family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1506.
    HOGENOMiHOG000189891.
    KOiK01282.
    OMAiETKFWYQ.
    OrthoDBiEOG72VHFG.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5B934-1 [UniParc]FASTAAdd to Basket

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    MRSSEDREDS ELLPANRPRS PSRSSYDSDD SGLSVDSILE EQKYNAATNE    50
    TLGLPQEMRY HDEEGGEAGS NEALHTKASS SRSRRLLWLV VLLCCGGWVV 100
    AFVLFITQGR ADYRTATDEL QSDNSGSFSD GTSSGKPLTL QQVLSGVFLP 150
    RGHAISWVAG PDGEDGLLIE RGEDDEAGYL RINDIRQDGK VNRVLMQKPT 200
    VGVDGRTIKP SATRPSPDLK KVLIISNQEK NWRHSFTASY WIFDVETQTA 250
    EPLDPNNIDG RVQLALWSPK SDAIAFVRDN NLYLRKLSSE RVVPITKDGG 300
    EQLFYGVPDW VYEEEVFSGN SVTWWSEDGS QIAFIRTNES AVPEFPVQYF 350
    LSRPSGKKPQ PGLENYPEVR EIKYPKAGAP NPFVNLQFYD VEQGEVFSVD 400
    TPDDFDDDDR LIIEVIWAAK GKVLVRTTNR ESDILKVFLV DTESRESKLI 450
    RIQDISELDG GWVEPTQSVR FIPADPDKGR PFDGYLDTVV HEGYDHLAYF 500
    TPLDNPEPIM LTSGEWEVVD APTAVDLTRG LVYFIATKEA PTERHLYRVR 550
    LDGSDLTPLT DTSQPGYYSV SFSDGAGYAL LSYQGPSIPW QSIISTEGEK 600
    TTTLRIIEDN TDLSKLVAQY ALPTENYQNI TIDGFTLQVV ERRPPHFNPA 650
    RKYPVLFHLY GGPGSQTVDR RFNVDFQSYV AASLGYIVVT VDGRGTGFIG 700
    RAARCIIRGN IGHYEAIDQI ATAKNWAQKP YVDESRMAIW GWSYGGFMTL 750
    KTLEQDAGET FQYGMAVAPV TDWRFYDSVY TERYMHTPQH NPTGYDNTSI 800
    SDMAALHNNV RFLVIHGASD DNVHIQNTLT LIDKLDLASV QNYDVHFYPD 850
    SDHSIFFHNA HTMVYERLAS WLVNAFNGEW HRTANPVPDE SMLRRLAKRV 900
    WPGFAH 906
    Length:906
    Mass (Da):101,960
    Last modified:July 27, 2011 - v2
    Checksum:i49ACD99EF348E99F
    GO

    Sequence cautioni

    The sequence DAA01787.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence EAA63517.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BK001296 Genomic DNA. Translation: DAA01787.1. Sequence problems.
    AACD01000051 Genomic DNA. Translation: EAA63517.1. Sequence problems.
    BN001306 Genomic DNA. Translation: CBF83695.1.
    RefSeqiXP_660550.1. XM_655458.1.

    Genome annotation databases

    EnsemblFungiiCADANIAT00010138; CADANIAP00010138; CADANIAG00010138.
    GeneIDi2873731.
    KEGGiani:AN2946.2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BK001296 Genomic DNA. Translation: DAA01787.1 . Sequence problems.
    AACD01000051 Genomic DNA. Translation: EAA63517.1 . Sequence problems.
    BN001306 Genomic DNA. Translation: CBF83695.1 .
    RefSeqi XP_660550.1. XM_655458.1.

    3D structure databases

    ProteinModelPortali Q5B934.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 162425.CADANIAP00010138.

    Protein family/group databases

    MEROPSi S09.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADANIAT00010138 ; CADANIAP00010138 ; CADANIAG00010138 .
    GeneIDi 2873731.
    KEGGi ani:AN2946.2.

    Phylogenomic databases

    eggNOGi COG1506.
    HOGENOMi HOG000189891.
    KOi K01282.
    OMAi ETKFWYQ.
    OrthoDBi EOG72VHFG.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genomics reveals sexual secrets of Aspergillus."
      Dyer P.S., Paoletti M., Archer D.B.
      Microbiology 149:2301-2303(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
    3. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
      Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
      , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
      Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

    Entry informationi

    Entry nameiDAPB_EMENI
    AccessioniPrimary (citable) accession number: Q5B934
    Secondary accession number(s): C8VJ32, Q7SI80
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 56 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3