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Q5B934 (DAPB_EMENI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable dipeptidyl-aminopeptidase B

Short name=DPAP B
EC=3.4.14.5
Gene names
Name:dapB
Synonyms:ste13
ORF Names:AN2946
OrganismEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) [Reference proteome]
Taxonomic identifier227321 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length906 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activity

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Subcellular location

Vacuole membrane; Single-pass type II membrane protein By similarity. Note: Lysosome-like vacuoles By similarity.

Sequence similarities

Belongs to the peptidase S9B family.

Sequence caution

The sequence DAA01787.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence EAA63517.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 906906Probable dipeptidyl-aminopeptidase B
PRO_0000412145

Regions

Topological domain1 – 8585Cytoplasmic Potential
Transmembrane86 – 10621Helical; Signal-anchor for type II membrane protein; Potential
Topological domain107 – 906800Vacuolar Potential
Compositional bias403 – 4097Poly-Asp

Sites

Active site7431Charge relay system By similarity
Active site8201Charge relay system By similarity
Active site8531Charge relay system By similarity

Amino acid modifications

Glycosylation3381N-linked (GlcNAc...) Potential
Glycosylation6291N-linked (GlcNAc...) Potential
Glycosylation7971N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q5B934 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 49ACD99EF348E99F

FASTA906101,960
        10         20         30         40         50         60 
MRSSEDREDS ELLPANRPRS PSRSSYDSDD SGLSVDSILE EQKYNAATNE TLGLPQEMRY 

        70         80         90        100        110        120 
HDEEGGEAGS NEALHTKASS SRSRRLLWLV VLLCCGGWVV AFVLFITQGR ADYRTATDEL 

       130        140        150        160        170        180 
QSDNSGSFSD GTSSGKPLTL QQVLSGVFLP RGHAISWVAG PDGEDGLLIE RGEDDEAGYL 

       190        200        210        220        230        240 
RINDIRQDGK VNRVLMQKPT VGVDGRTIKP SATRPSPDLK KVLIISNQEK NWRHSFTASY 

       250        260        270        280        290        300 
WIFDVETQTA EPLDPNNIDG RVQLALWSPK SDAIAFVRDN NLYLRKLSSE RVVPITKDGG 

       310        320        330        340        350        360 
EQLFYGVPDW VYEEEVFSGN SVTWWSEDGS QIAFIRTNES AVPEFPVQYF LSRPSGKKPQ 

       370        380        390        400        410        420 
PGLENYPEVR EIKYPKAGAP NPFVNLQFYD VEQGEVFSVD TPDDFDDDDR LIIEVIWAAK 

       430        440        450        460        470        480 
GKVLVRTTNR ESDILKVFLV DTESRESKLI RIQDISELDG GWVEPTQSVR FIPADPDKGR 

       490        500        510        520        530        540 
PFDGYLDTVV HEGYDHLAYF TPLDNPEPIM LTSGEWEVVD APTAVDLTRG LVYFIATKEA 

       550        560        570        580        590        600 
PTERHLYRVR LDGSDLTPLT DTSQPGYYSV SFSDGAGYAL LSYQGPSIPW QSIISTEGEK 

       610        620        630        640        650        660 
TTTLRIIEDN TDLSKLVAQY ALPTENYQNI TIDGFTLQVV ERRPPHFNPA RKYPVLFHLY 

       670        680        690        700        710        720 
GGPGSQTVDR RFNVDFQSYV AASLGYIVVT VDGRGTGFIG RAARCIIRGN IGHYEAIDQI 

       730        740        750        760        770        780 
ATAKNWAQKP YVDESRMAIW GWSYGGFMTL KTLEQDAGET FQYGMAVAPV TDWRFYDSVY 

       790        800        810        820        830        840 
TERYMHTPQH NPTGYDNTSI SDMAALHNNV RFLVIHGASD DNVHIQNTLT LIDKLDLASV 

       850        860        870        880        890        900 
QNYDVHFYPD SDHSIFFHNA HTMVYERLAS WLVNAFNGEW HRTANPVPDE SMLRRLAKRV 


WPGFAH 

« Hide

References

« Hide 'large scale' references
[1]"Genomics reveals sexual secrets of Aspergillus."
Dyer P.S., Paoletti M., Archer D.B.
Microbiology 149:2301-2303(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
[2]"Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae."
Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H. expand/collapse author list , Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L., Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.
Nature 438:1105-1115(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
[3]"The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G. expand/collapse author list , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BK001296 Genomic DNA. Translation: DAA01787.1. Sequence problems.
AACD01000051 Genomic DNA. Translation: EAA63517.1. Sequence problems.
BN001306 Genomic DNA. Translation: CBF83695.1.
RefSeqXP_660550.1. XM_655458.1.

3D structure databases

ProteinModelPortalQ5B934.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING162425.CADANIAP00010138.

Protein family/group databases

MEROPSS09.006.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADANIAT00010138; CADANIAP00010138; CADANIAG00010138.
GeneID2873731.
KEGGani:AN2946.2.

Phylogenomic databases

eggNOGCOG1506.
HOGENOMHOG000189891.
KOK01282.
OMAETKFWYQ.
OrthoDBEOG72VHFG.

Family and domain databases

Gene3D2.140.10.30. 1 hit.
InterProIPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPB_EMENI
AccessionPrimary (citable) accession number: Q5B934
Secondary accession number(s): C8VJ32, Q7SI80
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries