SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5B934

- DAPB_EMENI

UniProt

Q5B934 - DAPB_EMENI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Probable dipeptidyl-aminopeptidase B
Gene
dapB, ste13, AN2946
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei743 – 7431Charge relay system By similarity
Active sitei820 – 8201Charge relay system By similarity
Active sitei853 – 8531Charge relay system By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:dapB
Synonyms:ste13
ORF Names:AN2946
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome VI

Subcellular locationi

Vacuole membrane; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8585Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei86 – 10621Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini107 – 906800Vacuolar Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 906906Probable dipeptidyl-aminopeptidase B
PRO_0000412145Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi338 – 3381N-linked (GlcNAc...) Reviewed prediction
Glycosylationi629 – 6291N-linked (GlcNAc...) Reviewed prediction
Glycosylationi797 – 7971N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00010138.

Structurei

3D structure databases

ProteinModelPortaliQ5B934.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi403 – 4097Poly-Asp

Sequence similaritiesi

Belongs to the peptidase S9B family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1506.
HOGENOMiHOG000189891.
KOiK01282.
OMAiETKFWYQ.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5B934-1 [UniParc]FASTAAdd to Basket

« Hide

MRSSEDREDS ELLPANRPRS PSRSSYDSDD SGLSVDSILE EQKYNAATNE    50
TLGLPQEMRY HDEEGGEAGS NEALHTKASS SRSRRLLWLV VLLCCGGWVV 100
AFVLFITQGR ADYRTATDEL QSDNSGSFSD GTSSGKPLTL QQVLSGVFLP 150
RGHAISWVAG PDGEDGLLIE RGEDDEAGYL RINDIRQDGK VNRVLMQKPT 200
VGVDGRTIKP SATRPSPDLK KVLIISNQEK NWRHSFTASY WIFDVETQTA 250
EPLDPNNIDG RVQLALWSPK SDAIAFVRDN NLYLRKLSSE RVVPITKDGG 300
EQLFYGVPDW VYEEEVFSGN SVTWWSEDGS QIAFIRTNES AVPEFPVQYF 350
LSRPSGKKPQ PGLENYPEVR EIKYPKAGAP NPFVNLQFYD VEQGEVFSVD 400
TPDDFDDDDR LIIEVIWAAK GKVLVRTTNR ESDILKVFLV DTESRESKLI 450
RIQDISELDG GWVEPTQSVR FIPADPDKGR PFDGYLDTVV HEGYDHLAYF 500
TPLDNPEPIM LTSGEWEVVD APTAVDLTRG LVYFIATKEA PTERHLYRVR 550
LDGSDLTPLT DTSQPGYYSV SFSDGAGYAL LSYQGPSIPW QSIISTEGEK 600
TTTLRIIEDN TDLSKLVAQY ALPTENYQNI TIDGFTLQVV ERRPPHFNPA 650
RKYPVLFHLY GGPGSQTVDR RFNVDFQSYV AASLGYIVVT VDGRGTGFIG 700
RAARCIIRGN IGHYEAIDQI ATAKNWAQKP YVDESRMAIW GWSYGGFMTL 750
KTLEQDAGET FQYGMAVAPV TDWRFYDSVY TERYMHTPQH NPTGYDNTSI 800
SDMAALHNNV RFLVIHGASD DNVHIQNTLT LIDKLDLASV QNYDVHFYPD 850
SDHSIFFHNA HTMVYERLAS WLVNAFNGEW HRTANPVPDE SMLRRLAKRV 900
WPGFAH 906
Length:906
Mass (Da):101,960
Last modified:July 27, 2011 - v2
Checksum:i49ACD99EF348E99F
GO

Sequence cautioni

The sequence DAA01787.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence EAA63517.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BK001296 Genomic DNA. Translation: DAA01787.1. Sequence problems.
AACD01000051 Genomic DNA. Translation: EAA63517.1. Sequence problems.
BN001306 Genomic DNA. Translation: CBF83695.1.
RefSeqiXP_660550.1. XM_655458.1.

Genome annotation databases

EnsemblFungiiCADANIAT00010138; CADANIAP00010138; CADANIAG00010138.
GeneIDi2873731.
KEGGiani:AN2946.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BK001296 Genomic DNA. Translation: DAA01787.1 . Sequence problems.
AACD01000051 Genomic DNA. Translation: EAA63517.1 . Sequence problems.
BN001306 Genomic DNA. Translation: CBF83695.1 .
RefSeqi XP_660550.1. XM_655458.1.

3D structure databases

ProteinModelPortali Q5B934.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 162425.CADANIAP00010138.

Protein family/group databases

MEROPSi S09.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00010138 ; CADANIAP00010138 ; CADANIAG00010138 .
GeneIDi 2873731.
KEGGi ani:AN2946.2.

Phylogenomic databases

eggNOGi COG1506.
HOGENOMi HOG000189891.
KOi K01282.
OMAi ETKFWYQ.
OrthoDBi EOG72VHFG.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomics reveals sexual secrets of Aspergillus."
    Dyer P.S., Paoletti M., Archer D.B.
    Microbiology 149:2301-2303(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  3. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiDAPB_EMENI
AccessioniPrimary (citable) accession number: Q5B934
Secondary accession number(s): C8VJ32, Q7SI80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 27, 2011
Last modified: June 11, 2014
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi