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Q5B934

- DAPB_EMENI

UniProt

Q5B934 - DAPB_EMENI

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Protein

Probable dipeptidyl-aminopeptidase B

Gene

dapB

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei743 – 7431Charge relay systemBy similarity
Active sitei820 – 8201Charge relay systemBy similarity
Active sitei853 – 8531Charge relay systemBy similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:dapB
Synonyms:ste13
ORF Names:AN2946
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome VI

Subcellular locationi

Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8585CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei86 – 10621Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini107 – 906800VacuolarSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuole Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 906906Probable dipeptidyl-aminopeptidase BPRO_0000412145Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi338 – 3381N-linked (GlcNAc...)Sequence Analysis
Glycosylationi629 – 6291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi797 – 7971N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00010138.

Structurei

3D structure databases

ProteinModelPortaliQ5B934.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi403 – 4097Poly-Asp

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1506.
HOGENOMiHOG000189891.
InParanoidiQ5B934.
KOiK01282.
OMAiETKFWYQ.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5B934-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRSSEDREDS ELLPANRPRS PSRSSYDSDD SGLSVDSILE EQKYNAATNE
60 70 80 90 100
TLGLPQEMRY HDEEGGEAGS NEALHTKASS SRSRRLLWLV VLLCCGGWVV
110 120 130 140 150
AFVLFITQGR ADYRTATDEL QSDNSGSFSD GTSSGKPLTL QQVLSGVFLP
160 170 180 190 200
RGHAISWVAG PDGEDGLLIE RGEDDEAGYL RINDIRQDGK VNRVLMQKPT
210 220 230 240 250
VGVDGRTIKP SATRPSPDLK KVLIISNQEK NWRHSFTASY WIFDVETQTA
260 270 280 290 300
EPLDPNNIDG RVQLALWSPK SDAIAFVRDN NLYLRKLSSE RVVPITKDGG
310 320 330 340 350
EQLFYGVPDW VYEEEVFSGN SVTWWSEDGS QIAFIRTNES AVPEFPVQYF
360 370 380 390 400
LSRPSGKKPQ PGLENYPEVR EIKYPKAGAP NPFVNLQFYD VEQGEVFSVD
410 420 430 440 450
TPDDFDDDDR LIIEVIWAAK GKVLVRTTNR ESDILKVFLV DTESRESKLI
460 470 480 490 500
RIQDISELDG GWVEPTQSVR FIPADPDKGR PFDGYLDTVV HEGYDHLAYF
510 520 530 540 550
TPLDNPEPIM LTSGEWEVVD APTAVDLTRG LVYFIATKEA PTERHLYRVR
560 570 580 590 600
LDGSDLTPLT DTSQPGYYSV SFSDGAGYAL LSYQGPSIPW QSIISTEGEK
610 620 630 640 650
TTTLRIIEDN TDLSKLVAQY ALPTENYQNI TIDGFTLQVV ERRPPHFNPA
660 670 680 690 700
RKYPVLFHLY GGPGSQTVDR RFNVDFQSYV AASLGYIVVT VDGRGTGFIG
710 720 730 740 750
RAARCIIRGN IGHYEAIDQI ATAKNWAQKP YVDESRMAIW GWSYGGFMTL
760 770 780 790 800
KTLEQDAGET FQYGMAVAPV TDWRFYDSVY TERYMHTPQH NPTGYDNTSI
810 820 830 840 850
SDMAALHNNV RFLVIHGASD DNVHIQNTLT LIDKLDLASV QNYDVHFYPD
860 870 880 890 900
SDHSIFFHNA HTMVYERLAS WLVNAFNGEW HRTANPVPDE SMLRRLAKRV

WPGFAH
Length:906
Mass (Da):101,960
Last modified:July 27, 2011 - v2
Checksum:i49ACD99EF348E99F
GO

Sequence cautioni

The sequence DAA01787.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence EAA63517.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BK001296 Genomic DNA. Translation: DAA01787.1. Sequence problems.
AACD01000051 Genomic DNA. Translation: EAA63517.1. Sequence problems.
BN001306 Genomic DNA. Translation: CBF83695.1.
RefSeqiXP_660550.1. XM_655458.1.

Genome annotation databases

EnsemblFungiiCADANIAT00010138; CADANIAP00010138; CADANIAG00010138.
GeneIDi2873731.
KEGGiani:AN2946.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BK001296 Genomic DNA. Translation: DAA01787.1 . Sequence problems.
AACD01000051 Genomic DNA. Translation: EAA63517.1 . Sequence problems.
BN001306 Genomic DNA. Translation: CBF83695.1 .
RefSeqi XP_660550.1. XM_655458.1.

3D structure databases

ProteinModelPortali Q5B934.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 162425.CADANIAP00010138.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00010138 ; CADANIAP00010138 ; CADANIAG00010138 .
GeneIDi 2873731.
KEGGi ani:AN2946.2.

Phylogenomic databases

eggNOGi COG1506.
HOGENOMi HOG000189891.
InParanoidi Q5B934.
KOi K01282.
OMAi ETKFWYQ.
OrthoDBi EOG72VHFG.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomics reveals sexual secrets of Aspergillus."
    Dyer P.S., Paoletti M., Archer D.B.
    Microbiology 149:2301-2303(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  3. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiDAPB_EMENI
AccessioniPrimary (citable) accession number: Q5B934
Secondary accession number(s): C8VJ32, Q7SI80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3