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Q5B6Q3

- EXGB_EMENI

UniProt

Q5B6Q3 - EXGB_EMENI

Protein

Glucan endo-1,6-beta-glucosidase B

Gene

exgB

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. Acts on lutean, pustulan and 1,6-oligo-beta-D-glucosides.1 Publication

    Catalytic activityi

    Random hydrolysis of (1->6)-linkages in (1->6)-beta-D-glucans.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei228 – 2281Proton donorBy similarity
    Active sitei330 – 3301NucleophileBy similarity

    GO - Molecular functioni

    1. glucan endo-1,6-beta-glucosidase activity Source: ASPGD

    GO - Biological processi

    1. glucan catabolic process Source: ASPGD

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation

    Protein family/group databases

    CAZyiGH5. Glycoside Hydrolase Family 5.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucan endo-1,6-beta-glucosidase B (EC:3.2.1.75)
    Alternative name(s):
    Beta-1,6-glucanase B
    Endo-1,6-beta-D-glucanase B
    Endo-1,6-beta-glucanase B
    Gene namesi
    Name:exgB
    ORF Names:AN3777
    OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
    Taxonomic identifieri227321 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000000560: Chromosome II

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 409393Glucan endo-1,6-beta-glucosidase BPRO_0000394710Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi35 – 351N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ5B6Q3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2730.
    HOGENOMiHOG000217590.
    OMAiSEHFPQG.
    OrthoDBiEOG776T0C.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR001547. Glyco_hydro_5.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF00150. Cellulase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5B6Q3-1 [UniParc]FASTAAdd to Basket

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    MKFILPLFTS LPVALAWLPG IDKDIYSAAG TNIFNVTSAS SKRWLPASKK    50
    IRGVNLGSHF VIEPWMASMA WSNMGCSGQR SEFDCVMALG QETADQAFAD 100
    HWGSWITQDD INQMVQYGLN TIRIPVGYWL KEDLVYADSE HFPKGGIGYL 150
    EDVCGWASDA GMYIIIDLHG APGAQQPKQP FTGQYAPNPG FYQDYQYDRA 200
    LEFLEWMTTS IHQNNKFRNV GMLEIVNEPV QNADQASSMI NSYYPSAFTR 250
    IRNTESSLGI TSNNYLHIQM MNEKWGSGDP TQSLTDNYFA AYDDHRYVKW 300
    DSSVAVDKES YISASCVDDR GGNWPTIVGE WSLSVPDNVE HTADWEPSSN 350
    TDFYARWFAA QAIAYEKQEG WVFWSWKAQL GDYRWSYKDA VDAGVIPKDL 400
    DSIYDYSPC 409
    Length:409
    Mass (Da):46,267
    Last modified:April 26, 2005 - v1
    Checksum:i83704098EDC15087
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ490491 mRNA. Translation: ABF50867.1.
    AACD01000061 Genomic DNA. Translation: EAA59985.1.
    BN001302 Genomic DNA. Translation: CBF75405.1.
    RefSeqiXP_661381.1. XM_656289.1.

    Genome annotation databases

    EnsemblFungiiCADANIAT00004938; CADANIAP00004938; CADANIAG00004938.
    GeneIDi2873201.
    KEGGiani:AN3777.2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ490491 mRNA. Translation: ABF50867.1 .
    AACD01000061 Genomic DNA. Translation: EAA59985.1 .
    BN001302 Genomic DNA. Translation: CBF75405.1 .
    RefSeqi XP_661381.1. XM_656289.1.

    3D structure databases

    ProteinModelPortali Q5B6Q3.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH5. Glycoside Hydrolase Family 5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADANIAT00004938 ; CADANIAP00004938 ; CADANIAG00004938 .
    GeneIDi 2873201.
    KEGGi ani:AN3777.2.

    Phylogenomic databases

    eggNOGi COG2730.
    HOGENOMi HOG000217590.
    OMAi SEHFPQG.
    OrthoDBi EOG776T0C.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR001547. Glyco_hydro_5.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF00150. Cellulase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Development and application of a suite of polysaccharide-degrading enzymes for analyzing plant cell walls."
      Bauer S., Vasu P., Persson S., Mort A.J., Somerville C.R.
      Proc. Natl. Acad. Sci. U.S.A. 103:11417-11422(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
    3. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
      Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
      , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
      Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

    Entry informationi

    Entry nameiEXGB_EMENI
    AccessioniPrimary (citable) accession number: Q5B6Q3
    Secondary accession number(s): C8V716, Q1HFT3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3