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Q5B6Q3

- EXGB_EMENI

UniProt

Q5B6Q3 - EXGB_EMENI

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Protein

Glucan endo-1,6-beta-glucosidase B

Gene

exgB

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. Acts on lutean, pustulan and 1,6-oligo-beta-D-glucosides.1 Publication

Catalytic activityi

Random hydrolysis of (1->6)-linkages in (1->6)-beta-D-glucans.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei228 – 2281Proton donorBy similarity
Active sitei330 – 3301NucleophileBy similarity

GO - Molecular functioni

  1. glucan endo-1,6-beta-glucosidase activity Source: ASPGD

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. glucan catabolic process Source: ASPGD
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation

Protein family/group databases

CAZyiGH5. Glycoside Hydrolase Family 5.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucan endo-1,6-beta-glucosidase B (EC:3.2.1.75)
Alternative name(s):
Beta-1,6-glucanase B
Endo-1,6-beta-D-glucanase B
Endo-1,6-beta-glucanase B
Gene namesi
Name:exgB
ORF Names:AN3777
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome II

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Chaini17 – 409393Glucan endo-1,6-beta-glucosidase BPRO_0000394710Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi35 – 351N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ5B6Q3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2730.
HOGENOMiHOG000217590.
InParanoidiQ5B6Q3.
OMAiSEHFPQG.
OrthoDBiEOG776T0C.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5B6Q3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKFILPLFTS LPVALAWLPG IDKDIYSAAG TNIFNVTSAS SKRWLPASKK
60 70 80 90 100
IRGVNLGSHF VIEPWMASMA WSNMGCSGQR SEFDCVMALG QETADQAFAD
110 120 130 140 150
HWGSWITQDD INQMVQYGLN TIRIPVGYWL KEDLVYADSE HFPKGGIGYL
160 170 180 190 200
EDVCGWASDA GMYIIIDLHG APGAQQPKQP FTGQYAPNPG FYQDYQYDRA
210 220 230 240 250
LEFLEWMTTS IHQNNKFRNV GMLEIVNEPV QNADQASSMI NSYYPSAFTR
260 270 280 290 300
IRNTESSLGI TSNNYLHIQM MNEKWGSGDP TQSLTDNYFA AYDDHRYVKW
310 320 330 340 350
DSSVAVDKES YISASCVDDR GGNWPTIVGE WSLSVPDNVE HTADWEPSSN
360 370 380 390 400
TDFYARWFAA QAIAYEKQEG WVFWSWKAQL GDYRWSYKDA VDAGVIPKDL

DSIYDYSPC
Length:409
Mass (Da):46,267
Last modified:April 26, 2005 - v1
Checksum:i83704098EDC15087
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ490491 mRNA. Translation: ABF50867.1.
AACD01000061 Genomic DNA. Translation: EAA59985.1.
BN001302 Genomic DNA. Translation: CBF75405.1.
RefSeqiXP_661381.1. XM_656289.1.

Genome annotation databases

EnsemblFungiiCADANIAT00004938; CADANIAP00004938; CADANIAG00004938.
GeneIDi2873201.
KEGGiani:AN3777.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ490491 mRNA. Translation: ABF50867.1 .
AACD01000061 Genomic DNA. Translation: EAA59985.1 .
BN001302 Genomic DNA. Translation: CBF75405.1 .
RefSeqi XP_661381.1. XM_656289.1.

3D structure databases

ProteinModelPortali Q5B6Q3.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH5. Glycoside Hydrolase Family 5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00004938 ; CADANIAP00004938 ; CADANIAG00004938 .
GeneIDi 2873201.
KEGGi ani:AN3777.2.

Phylogenomic databases

eggNOGi COG2730.
HOGENOMi HOG000217590.
InParanoidi Q5B6Q3.
OMAi SEHFPQG.
OrthoDBi EOG776T0C.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00150. Cellulase. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Development and application of a suite of polysaccharide-degrading enzymes for analyzing plant cell walls."
    Bauer S., Vasu P., Persson S., Mort A.J., Somerville C.R.
    Proc. Natl. Acad. Sci. U.S.A. 103:11417-11422(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  3. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiEXGB_EMENI
AccessioniPrimary (citable) accession number: Q5B6Q3
Secondary accession number(s): C8V716, Q1HFT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: April 26, 2005
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3