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Q5B6C7

- BGLH_EMENI

UniProt

Q5B6C7 - BGLH_EMENI

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Protein

Probable beta-glucosidase H

Gene

bglH

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei225 – 2251By similarity

GO - Molecular functioni

  1. beta-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00696.

Protein family/group databases

CAZyiGH3. Glycoside Hydrolase Family 3.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-glucosidase H (EC:3.2.1.21)
Alternative name(s):
Beta-D-glucoside glucohydrolase H
Cellobiase H
Gentiobiase H
Gene namesi
Name:bglH
ORF Names:AN3903
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome II

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 831831Probable beta-glucosidase HPRO_0000394881Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi13 – 131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi474 – 4741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi514 – 5141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi604 – 6041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi629 – 6291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi726 – 7261N-linked (GlcNAc...)Sequence Analysis
Glycosylationi823 – 8231N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ5B6C7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini441 – 52282PA14Add
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family.Curated
Contains 1 PA14 domain.Curated

Phylogenomic databases

eggNOGiCOG1472.
HOGENOMiHOG000031215.
InParanoidiQ5B6C7.
OrthoDBiEOG7H799Q.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
3.40.50.1700. 2 hits.
InterProiIPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
IPR011658. PA14.
[Graphical view]
PANTHERiPTHR30620. PTHR30620. 1 hit.
PfamiPF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
PF07691. PA14. 1 hit.
[Graphical view]
PRINTSiPR00133. GLHYDRLASE3.
SMARTiSM00758. PA14. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.

Sequencei

Sequence statusi: Complete.

Q5B6C7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTRTFDIDYV LANISDQDKI ALLSGIDFWH THPIPQFNVP SVRVTDGPNG
60 70 80 90 100
IRGTKFFAGV PAACLPCGTA LGATWDRDLL RRAGELLGDE CIAKGAHCWL
110 120 130 140 150
GPTVNMQRSP LGGRGFESFS EDPYLAGVAA ASMIVGCESK GIIATVKHFV
160 170 180 190 200
GNDQEHERRA VDVIVTPRAL REIYLRPFQI VARDARPGAL MTSYNKVNGK
210 220 230 240 250
HVVEDPKMYD LIRKDWGWDP LVMSDWYGTY TTIDSTNAGL DLEMPGVSRY
260 270 280 290 300
RGKYIESAMQ ARLIKSSTLD ARARKVLEFV QRASRTKVSE VEKGRNHPED
310 320 330 340 350
RALMRTLCSN SIVLLKNEEN ILPLPKNVKK IALIGSHIKT PAISGGGSAA
360 370 380 390 400
LKPYYASTLY DAVREALPNA EVLYETGAHA HNMLPVIDRL LSNAVIHFYN
410 420 430 440 450
EPMTQPNRKC LGTEPVTTTA FQFMDYKLAG LNRALFWSTL IGDFTPDQSG
460 470 480 490 500
IWDFGLSVFG TANLYINDEL IIDNTTKQTK GTSFFGKGTR EEIGSMKLTA
510 520 530 540 550
GQTYKIRIEF GSANTTTMKT TGMVNFGGGA ANLGASLRLD AEEMINRAVK
560 570 580 590 600
AAEDADYAII CTGLNQDWES EGFDRPHMDL PPVGIDKMIS GVLDIAAHKT
610 620 630 640 650
VIVNQSGTPV TMPWASRAKS IVHSWYGGNE TGHGIADILF GDVNPSGKLS
660 670 680 690 700
LSWPIDVRHN PAYLNYASVG GRVLYGEDIY VGYRFYEKTG REVLFPFGHG
710 720 730 740 750
LSYTTFAVSP EALVSPGTFT PENPSNATVK IKNIGGAAGA QVLQLYVAAP
760 770 780 790 800
NSPTPRPQKE LQGFEKVFLR PGEEKTVIIR LDKYATSFWD EIEGMWKSEA
810 820 830
GVYEVLIGTS SEDIVARGQF EVNQTRYWSG L
Length:831
Mass (Da):91,333
Last modified:June 15, 2010 - v2
Checksum:i8FD1F0D0767812A6
GO

Sequence cautioni

The sequence CBF75131.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence EAA58834.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000063 Genomic DNA. Translation: EAA58834.1. Sequence problems.
BN001302 Genomic DNA. Translation: CBF75131.1. Sequence problems.
RefSeqiXP_661507.1. XM_656415.1.

Genome annotation databases

EnsemblFungiiCADANIAT00004796; CADANIAP00004796; CADANIAG00004796.
GeneIDi2873323.
KEGGiani:AN3903.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000063 Genomic DNA. Translation: EAA58834.1 . Sequence problems.
BN001302 Genomic DNA. Translation: CBF75131.1 . Sequence problems.
RefSeqi XP_661507.1. XM_656415.1.

3D structure databases

ProteinModelPortali Q5B6C7.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH3. Glycoside Hydrolase Family 3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00004796 ; CADANIAP00004796 ; CADANIAG00004796 .
GeneIDi 2873323.
KEGGi ani:AN3903.2.

Phylogenomic databases

eggNOGi COG1472.
HOGENOMi HOG000031215.
InParanoidi Q5B6C7.
OrthoDBi EOG7H799Q.

Enzyme and pathway databases

UniPathwayi UPA00696 .

Family and domain databases

Gene3Di 3.20.20.300. 1 hit.
3.40.50.1700. 2 hits.
InterProi IPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
IPR011658. PA14.
[Graphical view ]
PANTHERi PTHR30620. PTHR30620. 1 hit.
Pfami PF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
PF07691. PA14. 1 hit.
[Graphical view ]
PRINTSi PR00133. GLHYDRLASE3.
SMARTi SM00758. PA14. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiBGLH_EMENI
AccessioniPrimary (citable) accession number: Q5B6C7
Secondary accession number(s): C8V6A3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: October 29, 2014
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3