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Q5B6C6

- BGLF_EMENI

UniProt

Q5B6C6 - BGLF_EMENI

Protein

Probable beta-glucosidase F

Gene

bglF

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose By similarity.By similarity

    Catalytic activityi

    Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei285 – 2851By similarity

    GO - Molecular functioni

    1. beta-glucosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellulose catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

    Enzyme and pathway databases

    UniPathwayiUPA00696.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable beta-glucosidase F (EC:3.2.1.21)
    Alternative name(s):
    Beta-D-glucoside glucohydrolase F
    Cellobiase F
    Gentiobiase F
    Gene namesi
    Name:bglF
    ORF Names:AN10482
    OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
    Taxonomic identifieri227321 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000000560: Chromosome II

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 868848Probable beta-glucosidase FPRO_0000394114Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi65 – 651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi73 – 731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi257 – 2571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi328 – 3281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi360 – 3601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi395 – 3951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi421 – 4211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi726 – 7261N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ5B6C6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 3 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG1472.
    HOGENOMiHOG000031215.
    OMAiENYITVE.
    OrthoDBiEOG7HMS8F.

    Family and domain databases

    Gene3Di3.20.20.300. 1 hit.
    3.40.50.1700. 1 hit.
    InterProiIPR026891. Fn3-like.
    IPR026892. Glyco_hydro_3.
    IPR019800. Glyco_hydro_3_AS.
    IPR002772. Glyco_hydro_3_C.
    IPR001764. Glyco_hydro_3_N.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR30620. PTHR30620. 1 hit.
    PfamiPF14310. Fn3-like. 1 hit.
    PF00933. Glyco_hydro_3. 1 hit.
    PF01915. Glyco_hydro_3_C. 1 hit.
    [Graphical view]
    PRINTSiPR00133. GLHYDRLASE3.
    SUPFAMiSSF51445. SSF51445. 1 hit.
    SSF52279. SSF52279. 1 hit.
    PROSITEiPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5B6C6-1 [UniParc]FASTAAdd to Basket

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    MAHRWLILAL VAAAAPRALA SPGPSLNERQ SDDEPFSPPY YPAPNGGWVS    50
    TWAEAYEKAH SIVSNLTLAE KVNLTTGTGI FMGPCAGQTG SVPRLGIPNL 100
    CLHDSPLGVR NTDHNTAFPP GITVGATFDK SLMYERGVGL GEEARGKGVN 150
    VLLGPSVGPL GRKPRGGRNW EGFGFDPVLQ GIGGAETIKG MQSTGLIACI 200
    KHFVGNEQEM HRMSSVVTQG YSSNIDDRTL HELYIWPFAE GVRAEVGSVM 250
    IAYNDVNKSS CSQNSKLING VLKDELGFQG FVVTDWLAHY GGVSSALAGL 300
    DMDMPGDGAV PLFGNSYWGP ELSRSILNGT VPVERLNDMV TRILATWYKM 350
    GQDQDYPLPN FSSNTEDEKG LLYPGAVISP IGVVNQYVNV QGNHNITARA 400
    IARDAITLLK NEGDLLPLRR NDSLKVFGTD AGPDPQGLNS CADKGCNRGV 450
    LTMGWGSGTS KLPYLITPQE AIANITPTAE FFITDSFPSS VDANDEDIAI 500
    VFINSDSGEN YITVDGNPGD RKTSGLHAWH NGDELVKAAA ERFSQVVVVI 550
    HTVGPIILEE WIDLDSVKAV LIAHLPGQEA GYSLTDVLFG DYSPSGHLPY 600
    TIPYQESNYP SSVGLLQQPF GQIQDYYTEG LYIDYRHFLK EDITPRYAFG 650
    HGLSYTTFEF SEPALSVVTP LDSAYPPSRP AKGPTPTYPN TIPPASEAAW 700
    PAKFNRIWRY IYPYLNNPQA DAAVANSSKT YPYPDGYSTD PQPPPRAGGA 750
    EGGNPALWDV AFSVQVTVTN TGQHSGRAVA QLYVELPDSL GLDTPSRQLR 800
    QFEKTKVLET GQSETLTLEV TRKDVSVWDV EVQDWKTVVG GEGVKIHIGE 850
    SVLDIRTECE VGGRCVTL 868
    Length:868
    Mass (Da):93,918
    Last modified:May 18, 2010 - v2
    Checksum:i2CBEC9AF65A2E6F2
    GO

    Sequence cautioni

    The sequence EAA58835.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACD01000063 Genomic DNA. Translation: EAA58835.1. Sequence problems.
    BN001302 Genomic DNA. Translation: CBF75129.1.
    RefSeqiXP_661508.1. XM_656416.1.

    Genome annotation databases

    EnsemblFungiiCADANIAT00004795; CADANIAP00004795; CADANIAG00004795.
    GeneIDi2873326.
    KEGGiani:AN3904.2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACD01000063 Genomic DNA. Translation: EAA58835.1 . Sequence problems.
    BN001302 Genomic DNA. Translation: CBF75129.1 .
    RefSeqi XP_661508.1. XM_656416.1.

    3D structure databases

    ProteinModelPortali Q5B6C6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADANIAT00004795 ; CADANIAP00004795 ; CADANIAG00004795 .
    GeneIDi 2873326.
    KEGGi ani:AN3904.2.

    Phylogenomic databases

    eggNOGi COG1472.
    HOGENOMi HOG000031215.
    OMAi ENYITVE.
    OrthoDBi EOG7HMS8F.

    Enzyme and pathway databases

    UniPathwayi UPA00696 .

    Family and domain databases

    Gene3Di 3.20.20.300. 1 hit.
    3.40.50.1700. 1 hit.
    InterProi IPR026891. Fn3-like.
    IPR026892. Glyco_hydro_3.
    IPR019800. Glyco_hydro_3_AS.
    IPR002772. Glyco_hydro_3_C.
    IPR001764. Glyco_hydro_3_N.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR30620. PTHR30620. 1 hit.
    Pfami PF14310. Fn3-like. 1 hit.
    PF00933. Glyco_hydro_3. 1 hit.
    PF01915. Glyco_hydro_3_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00133. GLHYDRLASE3.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    SSF52279. SSF52279. 1 hit.
    PROSITEi PS00775. GLYCOSYL_HYDROL_F3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
    2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
      Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
      , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
      Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

    Entry informationi

    Entry nameiBGLF_EMENI
    AccessioniPrimary (citable) accession number: Q5B6C6
    Secondary accession number(s): C8V6A2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 18, 2010
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 54 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3