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Protein

Probable glucan 1,3-beta-glucosidase A

Gene

exgA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. It could also function biosynthetically as a transglycosylase (By similarity).By similarity

Catalytic activityi

Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.

Cofactori

Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei198Proton donorBy similarity1
Active sitei296NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation
LigandManganese, Metal-binding

Protein family/group databases

CAZyiGH5 Glycoside Hydrolase Family 5

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glucan 1,3-beta-glucosidase A (EC:3.2.1.58)
Alternative name(s):
Exo-1,3-beta-glucanase 1
Exo-1,3-beta-glucanase A
Gene namesi
Name:exgA
Synonyms:exg1
ORF Names:AN4052
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome II
  • UP000005890 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000039353227 – 405Probable glucan 1,3-beta-glucosidase AAdd BLAST379

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi278 ↔ 403By similarity
Disulfide bondi304 ↔ 330By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi162425.CADANIAP00004629

Structurei

3D structure databases

ProteinModelPortaliQ5B5X8
SMRiQ5B5X8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000114462
InParanoidiQ5B5X8
KOiK01210
OrthoDBiEOG092C22A6

Family and domain databases

InterProiView protein in InterPro
IPR001547 Glyco_hydro_5
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00150 Cellulase, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5B5X8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPRISQAAI LAHSLLAVCT SAATLAEKVR GVNLGGWLVL EPWITPSLFD
60 70 80 90 100
EAGDEAVDEY TLTEVLGVEE AAARLSEHWN TFITEEDFAL IAEAGLNYVR
110 120 130 140 150
IPIGYWAAAP LDGEPYVSGQ LEHLDNAVAW ARAHNLKVIV DLHGAPGSQN
160 170 180 190 200
GFDNSGRRGP IGWQQGDTVE QTILAFETLA QRYLADDDTV TMIEALNEPH
210 220 230 240 250
VPGGINQDQL KDYYEETLAR VRKNSPEATL LLHDGFVQTE GWNGFMTGEN
260 270 280 290 300
VMMDTHHYEV FEGGQNAWSI EKHIDAACQL GRQHLQAADK PVIVGEWTGA
310 320 330 340 350
LSDCTRYLNG KGIGIRYDGT LGSNTAVGAC GSKSEGSVAG LSADEIANTR
360 370 380 390 400
RFIEAQLDAF ELRNGWVFWT WKTEGAPGWD MQDLLANGVF PQPLTDREFP

NQCNF
Length:405
Mass (Da):44,437
Last modified:April 20, 2010 - v2
Checksum:iDBC5551A2C1E64B8
GO

Sequence cautioni

The sequence CBF74803 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAA59523 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000065 Genomic DNA Translation: EAA59523.1 Sequence problems.
BN001302 Genomic DNA Translation: CBF74803.1 Sequence problems.
RefSeqiXP_661656.1, XM_656564.1

Genome annotation databases

EnsemblFungiiCADANIAT00004629; CADANIAP00004629; CADANIAG00004629
EAA59523; EAA59523; AN4052.2
GeneIDi2873465
KEGGiani:AN4052.2

Similar proteinsi

Entry informationi

Entry nameiEXGA_EMENI
AccessioniPrimary (citable) accession number: Q5B5X8
Secondary accession number(s): C8V5I6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: April 20, 2010
Last modified: May 23, 2018
This is version 80 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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