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Q5B5S8

- BGLA_EMENI

UniProt

Q5B5S8 - BGLA_EMENI

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Protein

Probable beta-glucosidase A

Gene

bglA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose By similarity.By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei283 – 2831By similarity

GO - Molecular functioni

  1. beta-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00696.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-glucosidase A (EC:3.2.1.21)
Alternative name(s):
Beta-D-glucoside glucohydrolase A
Cellobiase A
Gentiobiase A
Gene namesi
Name:bglA
Synonyms:bgl1
ORF Names:AN4102
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome II

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 863844Probable beta-glucosidase APRO_0000394100Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi65 – 651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi214 – 2141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi255 – 2551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi318 – 3181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi325 – 3251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi357 – 3571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi493 – 4931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi526 – 5261N-linked (GlcNAc...)Sequence Analysis
Glycosylationi545 – 5451N-linked (GlcNAc...)Sequence Analysis
Glycosylationi567 – 5671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi664 – 6641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi715 – 7151N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00004577.

Structurei

3D structure databases

ProteinModelPortaliQ5B5S8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1472.
HOGENOMiHOG000031215.
InParanoidiQ5B5S8.
OrthoDBiEOG7HMS8F.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
3.40.50.1700. 1 hit.
InterProiIPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR019800. Glyco_hydro_3_AS.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR30620. PTHR30620. 1 hit.
PfamiPF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
[Graphical view]
PRINTSiPR00133. GLHYDRLASE3.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.
PROSITEiPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5B5S8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLGWLEAAA LTAASVASAQ VKQDDLPVSP PYYPSPWSNG EGEWAEAYNR
60 70 80 90 100
AVQIVSQMTL DEKVNLTTGT GMSEKCVGQT GSVPRLGINS ICLQDGPLGI
110 120 130 140 150
RFTDYNSAFP AGVNVAATWD RQLAYIRGHA MGQEFSDKGI DVQLGPAAGP
160 170 180 190 200
LGRFPDGGRN WEGFSPDPVL SGVLFAETIK GIQDAGVIAT AKHYLLNEQE
210 220 230 240 250
HFRQVPEANG YGYNITETLS ENVDDKTLHE LYLWPFADAV RAGVGAIMCS
260 270 280 290 300
YQHLNNTQAC QNSHLLNKLL KAELGFQGFV MSDWSATHSG VGSALAGMDM
310 320 330 340 350
TMPGDIAFND GLSYYGPNLT ISVLNGTVPQ WRVDDMAVRV MAAFYKVGRD
360 370 380 390 400
RLATPPNFSS WTRAEKGYEH ASIDGGAYGT VNEFVDVQQD HASLIRRVGA
410 420 430 440 450
DSIVLLKNEG SLPLTGKERN VAILGEDAGS NPYGANGCDD RGCAQGTLAM
460 470 480 490 500
GWGSGTANFP YLVTPEQAIQ QEVLKGRGNV FAVTDNWALD KVNKTASEST
510 520 530 540 550
VSLVFVNAGA GEGFISVDGN EGDRKNLTLW KNGENLIKAA ASNCNNTIVV
560 570 580 590 600
IHSVGAVLVD QFYEHPNVTA ILWAGLPGQE SGNSLVDVLY GRVNPNGKSP
610 620 630 640 650
FTWGKTREAY GAPLLTEANN GNGAPQTDHT EGVFIDYRHF DRTNQTPIYE
660 670 680 690 700
FGHGLSYTTF KYSNLTVQKL NAPAYSPASG QTKAAPTFGT IGEAEDYVFP
710 720 730 740 750
DSITRVREFI YPWINSTDLK ESSGDPNYGW DDEDYIPEGA KDGSPQDVLP
760 770 780 790 800
SGGGAGGNPR LYDDLFRITA IIKNTGPVAG TEVPQLYVSL GGPNEPKVVL
810 820 830 840 850
RGFDKLVIQP GEERVFTTTL TRRDLSNWDM EKDDWVITSY PKKVFVGSSS
860
RKLPLRASLP AVQ
Length:863
Mass (Da):93,242
Last modified:May 18, 2010 - v2
Checksum:i3C46FE9E7731E2A2
GO

Sequence cautioni

The sequence CBF74704.1 differs from that shown. Reason: Frameshift at position 844.
The sequence EAA59363.1 differs from that shown. Reason: Frameshift at position 844.
The sequence CBF74704.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence EAA59363.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACD01000067 Genomic DNA. Translation: EAA59363.1. Sequence problems.
BN001302 Genomic DNA. Translation: CBF74704.1. Sequence problems.
RefSeqiXP_661706.1. XM_656614.1.

Genome annotation databases

EnsemblFungiiCADANIAT00004577; CADANIAP00004577; CADANIAG00004577.
GeneIDi2873521.
KEGGiani:AN4102.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACD01000067 Genomic DNA. Translation: EAA59363.1 . Sequence problems.
BN001302 Genomic DNA. Translation: CBF74704.1 . Sequence problems.
RefSeqi XP_661706.1. XM_656614.1.

3D structure databases

ProteinModelPortali Q5B5S8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 162425.CADANIAP00004577.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00004577 ; CADANIAP00004577 ; CADANIAG00004577 .
GeneIDi 2873521.
KEGGi ani:AN4102.2.

Phylogenomic databases

eggNOGi COG1472.
HOGENOMi HOG000031215.
InParanoidi Q5B5S8.
OrthoDBi EOG7HMS8F.

Enzyme and pathway databases

UniPathwayi UPA00696 .

Family and domain databases

Gene3Di 3.20.20.300. 1 hit.
3.40.50.1700. 1 hit.
InterProi IPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR019800. Glyco_hydro_3_AS.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR30620. PTHR30620. 1 hit.
Pfami PF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
[Graphical view ]
PRINTSi PR00133. GLHYDRLASE3.
SUPFAMi SSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.
PROSITEi PS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiBGLA_EMENI
AccessioniPrimary (citable) accession number: Q5B5S8
Secondary accession number(s): C8V5A6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3