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Protein

Probable beta-glucosidase A

Gene

bglA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathwayi: cellulose degradation

This protein is involved in the pathway cellulose degradation, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway cellulose degradation and in Glycan metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei283By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00696.

Protein family/group databases

CAZyiGH3. Glycoside Hydrolase Family 3.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-glucosidase A (EC:3.2.1.21)
Alternative name(s):
Beta-D-glucoside glucohydrolase A
Cellobiase A
Gentiobiase A
Gene namesi
Name:bglA
Synonyms:bgl1
ORF Names:AN4102
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome II
  • UP000005890 Componenti: Partially assembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000039410020 – 863Probable beta-glucosidase AAdd BLAST844

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi65N-linked (GlcNAc...)Sequence analysis1
Glycosylationi214N-linked (GlcNAc...)Sequence analysis1
Glycosylationi255N-linked (GlcNAc...)Sequence analysis1
Glycosylationi318N-linked (GlcNAc...)Sequence analysis1
Glycosylationi325N-linked (GlcNAc...)Sequence analysis1
Glycosylationi357N-linked (GlcNAc...)Sequence analysis1
Glycosylationi493N-linked (GlcNAc...)Sequence analysis1
Glycosylationi526N-linked (GlcNAc...)Sequence analysis1
Glycosylationi545N-linked (GlcNAc...)Sequence analysis1
Glycosylationi567N-linked (GlcNAc...)Sequence analysis1
Glycosylationi664N-linked (GlcNAc...)Sequence analysis1
Glycosylationi715N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ5B5S8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000031215.
InParanoidiQ5B5S8.
KOiK05349.
OrthoDBiEOG092C0ZJY.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
3.40.50.1700. 1 hit.
InterProiIPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR019800. Glyco_hydro_3_AS.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR30620. PTHR30620. 3 hits.
PfamiPF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
[Graphical view]
PRINTSiPR00133. GLHYDRLASE3.
SMARTiSM01217. Fn3_like. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.
PROSITEiPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5B5S8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLGWLEAAA LTAASVASAQ VKQDDLPVSP PYYPSPWSNG EGEWAEAYNR
60 70 80 90 100
AVQIVSQMTL DEKVNLTTGT GMSEKCVGQT GSVPRLGINS ICLQDGPLGI
110 120 130 140 150
RFTDYNSAFP AGVNVAATWD RQLAYIRGHA MGQEFSDKGI DVQLGPAAGP
160 170 180 190 200
LGRFPDGGRN WEGFSPDPVL SGVLFAETIK GIQDAGVIAT AKHYLLNEQE
210 220 230 240 250
HFRQVPEANG YGYNITETLS ENVDDKTLHE LYLWPFADAV RAGVGAIMCS
260 270 280 290 300
YQHLNNTQAC QNSHLLNKLL KAELGFQGFV MSDWSATHSG VGSALAGMDM
310 320 330 340 350
TMPGDIAFND GLSYYGPNLT ISVLNGTVPQ WRVDDMAVRV MAAFYKVGRD
360 370 380 390 400
RLATPPNFSS WTRAEKGYEH ASIDGGAYGT VNEFVDVQQD HASLIRRVGA
410 420 430 440 450
DSIVLLKNEG SLPLTGKERN VAILGEDAGS NPYGANGCDD RGCAQGTLAM
460 470 480 490 500
GWGSGTANFP YLVTPEQAIQ QEVLKGRGNV FAVTDNWALD KVNKTASEST
510 520 530 540 550
VSLVFVNAGA GEGFISVDGN EGDRKNLTLW KNGENLIKAA ASNCNNTIVV
560 570 580 590 600
IHSVGAVLVD QFYEHPNVTA ILWAGLPGQE SGNSLVDVLY GRVNPNGKSP
610 620 630 640 650
FTWGKTREAY GAPLLTEANN GNGAPQTDHT EGVFIDYRHF DRTNQTPIYE
660 670 680 690 700
FGHGLSYTTF KYSNLTVQKL NAPAYSPASG QTKAAPTFGT IGEAEDYVFP
710 720 730 740 750
DSITRVREFI YPWINSTDLK ESSGDPNYGW DDEDYIPEGA KDGSPQDVLP
760 770 780 790 800
SGGGAGGNPR LYDDLFRITA IIKNTGPVAG TEVPQLYVSL GGPNEPKVVL
810 820 830 840 850
RGFDKLVIQP GEERVFTTTL TRRDLSNWDM EKDDWVITSY PKKVFVGSSS
860
RKLPLRASLP AVQ
Length:863
Mass (Da):93,242
Last modified:May 18, 2010 - v2
Checksum:i3C46FE9E7731E2A2
GO

Sequence cautioni

The sequence CBF74704 differs from that shown. Reason: Frameshift at position 844.Curated
The sequence CBF74704 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAA59363 differs from that shown. Reason: Frameshift at position 844.Curated
The sequence EAA59363 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000067 Genomic DNA. Translation: EAA59363.1. Sequence problems.
BN001302 Genomic DNA. Translation: CBF74704.1. Sequence problems.
RefSeqiXP_661706.1. XM_656614.1.

Genome annotation databases

EnsemblFungiiCADANIAT00004577; CADANIAP00004577; CADANIAG00004577.
EAA59363; EAA59363; AN4102.2.
GeneIDi2873521.
KEGGiani:AN4102.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000067 Genomic DNA. Translation: EAA59363.1. Sequence problems.
BN001302 Genomic DNA. Translation: CBF74704.1. Sequence problems.
RefSeqiXP_661706.1. XM_656614.1.

3D structure databases

ProteinModelPortaliQ5B5S8.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH3. Glycoside Hydrolase Family 3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADANIAT00004577; CADANIAP00004577; CADANIAG00004577.
EAA59363; EAA59363; AN4102.2.
GeneIDi2873521.
KEGGiani:AN4102.2.

Phylogenomic databases

HOGENOMiHOG000031215.
InParanoidiQ5B5S8.
KOiK05349.
OrthoDBiEOG092C0ZJY.

Enzyme and pathway databases

UniPathwayiUPA00696.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
3.40.50.1700. 1 hit.
InterProiIPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR019800. Glyco_hydro_3_AS.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR30620. PTHR30620. 3 hits.
PfamiPF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
[Graphical view]
PRINTSiPR00133. GLHYDRLASE3.
SMARTiSM01217. Fn3_like. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.
PROSITEiPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBGLA_EMENI
AccessioniPrimary (citable) accession number: Q5B5S8
Secondary accession number(s): C8V5A6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: May 18, 2010
Last modified: September 7, 2016
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.