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Q5B430

- BTGC_EMENI

UniProt

Q5B430 - BTGC_EMENI

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Protein

Glucan endo-1,3-beta-glucosidase btgC

Gene
btgC, AN4700
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.1 Publication

Catalytic activityi

Hydrolysis of (1->3)-beta-D-glucosidic linkages in (1->3)-beta-D-glucans.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei551 – 5511Nucleophile By similarity
Active sitei619 – 6191Proton donor By similarity

GO - Molecular functioni

  1. glucan endo-1,3-beta-D-glucosidase activity Source: UniProtKB

GO - Biological processi

  1. glucan catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation

Protein family/group databases

CAZyiGH17. Glycoside Hydrolase Family 17.
mycoCLAPiLAM17A_EMENI.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucan endo-1,3-beta-glucosidase btgC (EC:3.2.1.39)
Alternative name(s):
Endo-1,3-beta-glucanase btgC
Laminarinase btgC
Gene namesi
Name:btgC
ORF Names:AN4700
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome III

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 274274Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei275 – 29521Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini296 – 649354Extracellular Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 649649Glucan endo-1,3-beta-glucosidase btgCPRO_0000395128Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi369 – 3691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi392 – 3921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi420 – 4201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi596 – 5961N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ5B430.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi222 – 30079Gly-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5309.
HOGENOMiHOG000173877.
OMAiSDNPYVP.
OrthoDBiEOG7P8PHC.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5B430-1 [UniParc]FASTAAdd to Basket

« Hide

MGDRSEQYGD IPPISSQHRM HGYGNNGEPA AMPGDGQQNW GSGPGIAHTH    50
SMRTASTATP GMDNLGPSAV GGGISGIALG VANTHDRQSG IDAFRDADAT 100
LGYIPAERGY HTTGADNPYV PSPPSVGPGP DESSEGLRSH ETFGSSAALS 150
AAGAPAGNWT PPSGSRHSFL DGSYQGVASG PYQRHSAYSS QDYPADINPD 200
DILDDGDDGF AAAPSNKPNA AGGAATGGAA GGLLGEFFGA KKAADASYDP 250
VPGAGLPSVE KYAKPRPSGA SRKRGWIIGG ILAFIVIGAI VGGAVGGTLG 300
NRRSETASES SEVSADDDTE TNGDLDKNSD EIKSLMAMEG LHKVFPGMDY 350
TPWGVQHPEC DKWPPSQNNV TRDMAVLSRL TNTVRLYGTD CNQTEMVLHA 400
IDRLELTDMK LWLGVWIDTN TTTNERQLSQ LYDILDKRSD HSVFKGAIIG 450
NEALYRAGST KEEARKNIID YMRQVRKHFN DHNIDIKVAT SDLGDNWDET 500
LADATDVVMS NVHPFFGGVE VSKAAGWTWS FWNSHNAPLT QGTNKGNIIA 550
EVGWPSGGGN DCGDGANCKD DTSGAVAGVK QMNQFMADWV CPALENGTDY 600
FWFEAFDEPW KVKFNKGDEQ WEDKWGLMDP GRNLKPGIEI PDCGGKTAA 649
Length:649
Mass (Da):68,963
Last modified:April 26, 2005 - v1
Checksum:i8476F1DF5B3F1D93
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ490493 mRNA. Translation: ABF50869.1.
AACD01000080 Genomic DNA. Translation: EAA60742.1.
BN001303 Genomic DNA. Translation: CBF76969.1.
RefSeqiXP_662304.1. XM_657212.1.

Genome annotation databases

EnsemblFungiiCADANIAT00005730; CADANIAP00005730; CADANIAG00005730.
GeneIDi2872500.
KEGGiani:AN4700.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ490493 mRNA. Translation: ABF50869.1 .
AACD01000080 Genomic DNA. Translation: EAA60742.1 .
BN001303 Genomic DNA. Translation: CBF76969.1 .
RefSeqi XP_662304.1. XM_657212.1.

3D structure databases

ProteinModelPortali Q5B430.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH17. Glycoside Hydrolase Family 17.
mycoCLAPi LAM17A_EMENI.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00005730 ; CADANIAP00005730 ; CADANIAG00005730 .
GeneIDi 2872500.
KEGGi ani:AN4700.2.

Phylogenomic databases

eggNOGi COG5309.
HOGENOMi HOG000173877.
OMAi SDNPYVP.
OrthoDBi EOG7P8PHC.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Development and application of a suite of polysaccharide-degrading enzymes for analyzing plant cell walls."
    Bauer S., Vasu P., Persson S., Mort A.J., Somerville C.R.
    Proc. Natl. Acad. Sci. U.S.A. 103:11417-11422(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  3. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiBTGC_EMENI
AccessioniPrimary (citable) accession number: Q5B430
Secondary accession number(s): C8VAX6, Q1HFT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: April 26, 2005
Last modified: February 19, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3