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Protein

DNA ligase

Gene

AN4883.2

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:AN4883.2Imported, ANIA_04883Imported
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)Imported
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560 Componenti: Chromosome III

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036006.
KOiK10747.
OMAiFIMEGEV.
OrthoDBiEOG7TXKRG.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5B3J7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPAKKRKR DTQPTRSIAS FFQGQTAKQT EKSEQLASLA DTEQHLSDEA
60 70 80 90 100
LARKLQAEWN NEQDFASPAT VPHSEPTAAS PSPEKDREQK KAKVGVLSLQ
110 120 130 140 150
SSTGTEDTIS LSVPFDQSPL VFDSSRYAGE LKAHWSAEGG NASYALLTRA
160 170 180 190 200
FVLANSTTSR IKIVDTLVNF LRVLIEGDPS SVLPAVWLAT NSISPPYHEL
210 220 230 240 250
ELGLGGSSIS KAFKKIYGLN SQGLKSLYDR LGDAGDVAFE AKKRQSFTLI
260 270 280 290 300
KPKPLSIKGV YQSLIKIAMS KGSGSQELKQ RIVEKLLQDT RGAEESRYIV
310 320 330 340 350
RTLVQNLRIG AVKTTMLIAL ARAFLVSKPD NATFTVHSQH ELARLKKEEL
360 370 380 390 400
AEIYSSAEEL VKASYARHPN YNDLVPCLLE IGVTEELLLR CGLQLHIPLM
410 420 430 440 450
PMLGSITRDL SEMLTKLQGR DFTCEFKYDG QRAQVHCDEA GKVSIFSRHL
460 470 480 490 500
EEMTEKYPDL VSLVPQIRGE GVSSFILEGE VVAVDQNGEL QPFQILTNRA
510 520 530 540 550
KKNVDIGEIK INVCLFAFDL MYLNGAPLLE RSLRERRELL RSLFMEIPNR
560 570 580 590 600
FTWVKSLDAT SADSEAVLDF FKSATENKCE GIMVKVLDNT LATNGSDSTN
610 620 630 640 650
SSITATPKAE AKETKKGGRR KALLSSYEPD KRLESWLKVK KDYSASSETL
660 670 680 690 700
DLIPVAGWHG NGRKAKWWSP ILLAVRNPET GGLQAVTKCM SGFSDKFYQA
710 720 730 740 750
NKEKYEEGSP NVISRPSYVE YNGEPDVWFE PQEVWEMAFA DITLSPTYPA
760 770 780 790 800
AIGLRFSDRS LQGISPMPVD DLQLCYRWQE NVKGRILAER ASAESIVATQ
810
LKRPYVALMN IIDYQT
Length:816
Mass (Da):90,777
Last modified:April 26, 2005 - v1
Checksum:iF3B92F444A46C6EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BN001303 Genomic DNA. Translation: CBF76559.1.
AACD01000084 Genomic DNA. Translation: EAA60961.1.
RefSeqiXP_662487.1. XM_657395.1.

Genome annotation databases

EnsemblFungiiCADANIAT00005522; CADANIAP00005522; CADANIAG00005522.
GeneIDi2872686.
KEGGiani:AN4883.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BN001303 Genomic DNA. Translation: CBF76559.1.
AACD01000084 Genomic DNA. Translation: EAA60961.1.
RefSeqiXP_662487.1. XM_657395.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADANIAT00005522; CADANIAP00005522; CADANIAG00005522.
GeneIDi2872686.
KEGGiani:AN4883.2.

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036006.
KOiK10747.
OMAiFIMEGEV.
OrthoDBiEOG7TXKRG.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M., Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H., Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T., Blitshsteyn B.
    , Bloom T., Blye J., Boguslavskiy L., Borowsky M., Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J., Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T., Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S., Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A., Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P., Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G., Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A., Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E., Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M., Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E., Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T., Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A., Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J., Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S., Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T., Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G., Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C., Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S., Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P., Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V., Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J., Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T., Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C., Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K., Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P., Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T., Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A., Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J., Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G., Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: FGSC A4.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4Imported and FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139Imported.
  3. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139Imported.
  4. "The 2008 update of the Aspergillus nidulans genome annotation: A community effort."
    Russo Wortman J., Mabey Gilsenan J., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J.M., Durek P., Espeso E., Fekete E., Flipphi M., Garcia Estrada C.
    , Geysens S., Goldman G., de Groot P.W.J., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A.K.W., Kim J-M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., MacCabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Posci I., Punt P.J., Ram A.F.J., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van der Vondervoot P.J.I., de Vries R.P., Walton J., Xiang X., Xiong Y., Ping Zeng A., Brandt B.W., Cornell M.J., van den Hondel C.A.M.J.J., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-S13(2009)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: FGSC A4Imported.

Entry informationi

Entry nameiQ5B3J7_EMENI
AccessioniPrimary (citable) accession number: Q5B3J7
Secondary accession number(s): C8V9T7
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: July 22, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.