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Q5B323 (CDC14_EMENI) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein phosphatase cdcA

EC=3.1.3.48
Gene names
Name:cdcA
ORF Names:AN5057
OrganismEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) [Reference proteome]
Taxonomic identifier227321 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length595 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protein phosphatase which antagonizes mitotic cyclin-dependent kinase nimX, the inactivation of which is essential for exit from mitosis. To access its substrates, is released from nucleolar sequestration during mitosis. Plays an essential in coordinating the nuclear division cycle with cytokinesis through the cytokinesis checkpoint. Involved in chromosome segregation, where it is required for meiosis I spindle dissambly as well as for establishing two consecutive chromosome segregation phases By similarity. Required for the transcription of the two major endoglucanase genes eglA and eglB and growth on synthetic cellulose as the sole carbon source. Ref.5

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Nucleus. Cytoplasm. Cell septum. Note: Does not localize to the nucleolus as its homologs do in S.cerevisiae and S.pombe. Accumulates within nuclei as they pass through interphase, displays a complex localization in mitosis, and localizes to the forming septum after mitosis is completed. Ref.4

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 595595Tyrosine-protein phosphatase cdcA
PRO_0000425254

Sites

Active site3221Phosphocysteine intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5B323 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: 4C2999314618E2B7

FASTA59566,129
        10         20         30         40         50         60 
MAGSTAGYGQ IIEYIQDKLY LASYDHTPDA KTPFPYPAEQ PKSPSKRRAQ ASPSKKRSPV 

        70         80         90        100        110        120 
YFTVDDTLLY NSFHADFGPL HIGHLYRFAV HFHDLLAANN DRAIVFYSRT DARSRANAAC 

       130        140        150        160        170        180 
LVACYMVLIQ SWPPHLALAP IAQADPPYMP FRDAGYSQAD FILNIQDVVY GVWKAKEQGV 

       190        200        210        220        230        240 
CGLRDFSLEE YEKFERVDMG DFNWISPHFL AFASPQHQPV APIPRDSPEY AALPSTVSEV 

       250        260        270        280        290        300 
RSSRLPLPFK NVLEHFATRG VGLVVRLNSE LYSPSYFTAL GISHIDMIFE DGTCPPLPLV 

       310        320        330        340        350        360 
KKFIRMAHEM INVKHKAIAV HCKAGLGRTG CLIGAYLIYR YGFTANEVIA FMRFMRPGMV 

       370        380        390        400        410        420 
VGPQQHWLHL NQGSFREWWF EDCMKEKLAQ MQPNPVTPGR SPAKHRAAAV TTPPQNGHSK 

       430        440        450        460        470        480 
RSALGEIDNN EATPIYDDNL PAPTPGQPRK SHRKDSRHHP YSRTASGSLV VDKDTRKTRR 

       490        500        510        520        530        540 
STDSSESEEE TQLRMLAKQR SSKSPAASPG QRSISYSATV TASYTLNDDI HEDRENWGGA 

       550        560        570        580        590 
AQPPKTPVTS KTSGAVSVSK VRSSSRRVTG ESKGVRKPSG RIGSTGSPVR VKAQA 

« Hide

References

« Hide 'large scale' references
[1]"Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae."
Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H. expand/collapse author list , Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L., Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.
Nature 438:1105-1115(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
[2]"The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G. expand/collapse author list , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
[3]"Analysis of all protein phosphatase genes in Aspergillus nidulans identifies a new mitotic regulator, fcp1."
Son S., Osmani S.A.
Eukaryot. Cell 8:573-585(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]"Gamma-tubulin regulates the anaphase-promoting complex/cyclosome during interphase."
Nayak T., Edgerton-Morgan H., Horio T., Xiong Y., De Souza C.P., Osmani S.A., Oakley B.R.
J. Cell Biol. 190:317-330(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[5]"Functional characterisation of the non-essential protein kinases and phosphatases regulating Aspergillus nidulans hydrolytic enzyme production."
Brown N.A., de Gouvea P.F., Krohn N.G., Savoldi M., Goldman G.H.
Biotechnol. Biofuels 6:91-91(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BN001303 Genomic DNA. Translation: CBF76183.1.
AACD01000085 Genomic DNA. Translation: EAA60051.1.
RefSeqXP_662661.1. XM_657569.1.

3D structure databases

ProteinModelPortalQ5B323.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING162425.CADANIAP00005331.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADANIAT00005331; CADANIAP00005331; CADANIAG00005331.
GeneID2872855.
KEGGani:AN5057.2.

Phylogenomic databases

eggNOGCOG2453.
HOGENOMHOG000198341.
KOK06639.
OMAVYGVWKA.
OrthoDBEOG7JQBXJ.

Family and domain databases

Gene3D3.90.190.10. 2 hits.
InterProIPR026070. CDC14.
IPR029260. DSPn.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERPTHR23339:SF27. PTHR23339:SF27. 1 hit.
PfamPF00782. DSPc. 1 hit.
PF14671. DSPn. 1 hit.
[Graphical view]
SUPFAMSSF52799. SSF52799. 2 hits.
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDC14_EMENI
AccessionPrimary (citable) accession number: Q5B323
Secondary accession number(s): C8V824
Entry history
Integrated into UniProtKB/Swiss-Prot: February 19, 2014
Last sequence update: April 26, 2005
Last modified: June 11, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families