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Q5B323

- CDC14_EMENI

UniProt

Q5B323 - CDC14_EMENI

Protein

Tyrosine-protein phosphatase cdcA

Gene

cdcA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Protein phosphatase which antagonizes mitotic cyclin-dependent kinase nimX, the inactivation of which is essential for exit from mitosis. To access its substrates, is released from nucleolar sequestration during mitosis. Plays an essential in coordinating the nuclear division cycle with cytokinesis through the cytokinesis checkpoint. Involved in chromosome segregation, where it is required for meiosis I spindle dissambly as well as for establishing two consecutive chromosome segregation phases By similarity. Required for the transcription of the two major endoglucanase genes eglA and eglB and growth on synthetic cellulose as the sole carbon source.By similarity1 Publication

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei322 – 3221Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. protein tyrosine/serine/threonine phosphatase activity Source: InterPro
    2. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. meiotic nuclear division Source: UniProtKB-KW
    2. mitotic nuclear division Source: UniProtKB-KW
    3. regulation of exit from mitosis Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Cell cycle, Cell division, Meiosis, Mitosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein phosphatase cdcA (EC:3.1.3.48)
    Gene namesi
    Name:cdcA
    ORF Names:AN5057
    OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
    Taxonomic identifieri227321 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000000560: Chromosome III

    Subcellular locationi

    Nucleus 1 Publication. Cytoplasm 1 Publication. Cell septum 1 Publication
    Note: Does not localize to the nucleolus as its homologs do in S.cerevisiae and S.pombe. Accumulates within nuclei as they pass through interphase, displays a complex localization in mitosis, and localizes to the forming septum after mitosis is completed.

    GO - Cellular componenti

    1. cell septum Source: UniProtKB-SubCell
    2. cytoplasm Source: UniProtKB-SubCell
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 595595Tyrosine-protein phosphatase cdcAPRO_0000425254Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi162425.CADANIAP00005331.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5B323.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2453.
    HOGENOMiHOG000198341.
    KOiK06639.
    OMAiVYGVWKA.
    OrthoDBiEOG7JQBXJ.

    Family and domain databases

    Gene3Di3.90.190.10. 2 hits.
    InterProiIPR026070. CDC14.
    IPR029260. DSPn.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PANTHERiPTHR23339:SF27. PTHR23339:SF27. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    PF14671. DSPn. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 2 hits.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5B323-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGSTAGYGQ IIEYIQDKLY LASYDHTPDA KTPFPYPAEQ PKSPSKRRAQ    50
    ASPSKKRSPV YFTVDDTLLY NSFHADFGPL HIGHLYRFAV HFHDLLAANN 100
    DRAIVFYSRT DARSRANAAC LVACYMVLIQ SWPPHLALAP IAQADPPYMP 150
    FRDAGYSQAD FILNIQDVVY GVWKAKEQGV CGLRDFSLEE YEKFERVDMG 200
    DFNWISPHFL AFASPQHQPV APIPRDSPEY AALPSTVSEV RSSRLPLPFK 250
    NVLEHFATRG VGLVVRLNSE LYSPSYFTAL GISHIDMIFE DGTCPPLPLV 300
    KKFIRMAHEM INVKHKAIAV HCKAGLGRTG CLIGAYLIYR YGFTANEVIA 350
    FMRFMRPGMV VGPQQHWLHL NQGSFREWWF EDCMKEKLAQ MQPNPVTPGR 400
    SPAKHRAAAV TTPPQNGHSK RSALGEIDNN EATPIYDDNL PAPTPGQPRK 450
    SHRKDSRHHP YSRTASGSLV VDKDTRKTRR STDSSESEEE TQLRMLAKQR 500
    SSKSPAASPG QRSISYSATV TASYTLNDDI HEDRENWGGA AQPPKTPVTS 550
    KTSGAVSVSK VRSSSRRVTG ESKGVRKPSG RIGSTGSPVR VKAQA 595
    Length:595
    Mass (Da):66,129
    Last modified:April 26, 2005 - v1
    Checksum:i4C2999314618E2B7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BN001303 Genomic DNA. Translation: CBF76183.1.
    AACD01000085 Genomic DNA. Translation: EAA60051.1.
    RefSeqiXP_662661.1. XM_657569.1.

    Genome annotation databases

    EnsemblFungiiCADANIAT00005331; CADANIAP00005331; CADANIAG00005331.
    GeneIDi2872855.
    KEGGiani:AN5057.2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BN001303 Genomic DNA. Translation: CBF76183.1 .
    AACD01000085 Genomic DNA. Translation: EAA60051.1 .
    RefSeqi XP_662661.1. XM_657569.1.

    3D structure databases

    ProteinModelPortali Q5B323.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 162425.CADANIAP00005331.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADANIAT00005331 ; CADANIAP00005331 ; CADANIAG00005331 .
    GeneIDi 2872855.
    KEGGi ani:AN5057.2.

    Phylogenomic databases

    eggNOGi COG2453.
    HOGENOMi HOG000198341.
    KOi K06639.
    OMAi VYGVWKA.
    OrthoDBi EOG7JQBXJ.

    Family and domain databases

    Gene3Di 3.90.190.10. 2 hits.
    InterProi IPR026070. CDC14.
    IPR029260. DSPn.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    PANTHERi PTHR23339:SF27. PTHR23339:SF27. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    PF14671. DSPn. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 2 hits.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
    2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
      Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
      , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
      Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
    3. "Analysis of all protein phosphatase genes in Aspergillus nidulans identifies a new mitotic regulator, fcp1."
      Son S., Osmani S.A.
      Eukaryot. Cell 8:573-585(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    4. "Gamma-tubulin regulates the anaphase-promoting complex/cyclosome during interphase."
      Nayak T., Edgerton-Morgan H., Horio T., Xiong Y., De Souza C.P., Osmani S.A., Oakley B.R.
      J. Cell Biol. 190:317-330(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    5. "Functional characterisation of the non-essential protein kinases and phosphatases regulating Aspergillus nidulans hydrolytic enzyme production."
      Brown N.A., de Gouvea P.F., Krohn N.G., Savoldi M., Goldman G.H.
      Biotechnol. Biofuels 6:91-91(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiCDC14_EMENI
    AccessioniPrimary (citable) accession number: Q5B323
    Secondary accession number(s): C8V824
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 19, 2014
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3