Reviewed, UniProtKB/Swiss-Prot Q5B1Z0 (CCPR2_EMENI)

Names and origin

Protein names

Recommended name:
    Putative heme-binding peroxidase
    EC=1.11.1.-

Gene names

ORF Names:

AN5440

Organism

Emericella nidulans (Aspergillus nidulans)

Taxonomic identifier

162425 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › Emericella

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Destroys radicals which are normally produced within the cells and which are toxic to biological systems By similarity.
Cofactor	Binds 1 heme B (iron-protoporphyrin IX) group per subunit By similarity.
Sequence similarities	Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.

Ontologies

Keywords
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to oxidative stress Inferred from electronic annotation. Source: InterPro
Molecular function	heme binding Inferred from electronic annotation. Source: InterPro peroxidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 312	312	Putative heme-binding peroxidase		PRO_0000055587
Sites
	Active site	38	1	Proton acceptor By similarity
	Active site	178	1	Tryptophan radical intermediate By similarity
	Metal binding	162	1	Iron (heme axial ligand) By similarity
	Site	34	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5B1Z0-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: FEF3CFBF0E54C880	FASTA	312	34,521
	10 20 30 40 50 60 MSKPGDYNAV RRDIAAQLKK PGYDDGSAGP VFVRLAWHSS GTYDAASDTG GSNGAGMRYE 70 80 90 100 110 120 AEGGDPANAG LQHGRAFLEP VKEKHPWITY SDLWTLAGVV AIEEMGGPKI PWLPGRTDFV 130 140 150 160 170 180 DDSKVPPRGR LPDGAQGADH LRFIFYRMGF NDQEIVALAG GHNLGRCHAD RSGFQGPWVN 190 200 210 220 230 240 NPTRFSNQFF KLLLNMEWKP KTLENGVSQF VYIDPEAEDH EEPLMMLPTD VALRDDPAFR 250 260 270 280 290 300 PWVERYAKDK DLFFDHFSKA FAKLIELGIQ RDASGKVTNT DNVKGGYHSA PKKSDEPTGP 310 PRPHTAQRAA KL

References

[1]

"Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae." Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H. , Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L., Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W. Nature 438:1105-1115(2005) [PubMed: 16372000] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FGSC 4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACD01000094 Genomic DNA. Translation: EAA62600.1.
RefSeq	XP_663044.1.
3D structure databases
ModBase	Search...
Protein family/group databases
PeroxiBase	3835. AniCcP01.
Genome annotation databases
GeneID	2871733.
KEGG	ani:AN5440.2.
Family and domain databases
InterPro	IPR002207. Asc_perxdse. IPR002016. Haem_peroxidase_pln/fun/bac. IPR019794. Peroxidases_AS. IPR019793. Peroxidases_heam-ligand_BS. [Graphical view]
Pfam	PF00141. peroxidase. 1 hit. [Graphical view]
PRINTS	PR00459. ASPEROXIDASE. PR00458. PEROXIDASE.
PROSITE	PS00435. PEROXIDASE_1. False negative. PS00436. PEROXIDASE_2. 1 hit. PS50873. PEROXIDASE_4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CCPR2_EMENI

Accession

Primary (citable) accession number: Q5B1Z0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	April 26, 2005
Last modified:	June 16, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)