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Reviewed, UniProtKB/Swiss-Prot Q5B0W8 (LKHA4_EMENI)

Last modified February 9, 2010. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Leukotriene A-4 hydrolase
    EC=3.3.2.6
Alternative name(s):
    Leukotriene A(4) hydrolase
      Short name=LTA-4 hydrolase
Gene names
ORF Names: AN5812
OrganismEmericella nidulans (Aspergillus nidulans) [Complete proteome]
Taxonomic identifier162425 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeEmericella

Protein attributes

Sequence length618 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Hydrolyzes an epoxide moiety of LTA4 to form LTB4. The enzyme also has some peptidase activity By similarity.

Catalytic activity

(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Pathway

Lipid metabolism; leukotriene B4 biosynthesis.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the peptidase M1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 618618Leukotriene A-4 hydrolase
PRO_0000324929

Sites

Active site3021 By similarity
Active site3891Proton donor By similarity
Metal binding3011Zinc; catalytic By similarity
Metal binding3051Zinc; catalytic By similarity
Metal binding3241Zinc; catalytic By similarity
Site2051Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5B0W8-1 [UniParc].

Last modified March 18, 2008. Version 2.
Checksum: AEEB8A7BB540D9C9

FASTA61870,100
        10         20         30         40         50         60 
MATLMNPVRD PNTLSNYNNW LCTHTTANFE IFFEEKKLVG NVVHKLRSIT NAETDEIILD 

        70         80         90        100        110        120 
SHHVDIRNVQ VAGLPVKAWE LLPPLGPYGT ALKIKLENPV GLNEIIDVDI AVQTTKECTA 

       130        140        150        160        170        180 
LQWLTPAQTS NKKHPYMFSQ CQAIHARSIF PCQDTPDVKC TFDFNITSPL PVIASGLPVR 

       190        200        210        220        230        240 
STSTVPQSGV KTLHRFHQKV PIPSYLFALA SGDIAEAAIG PRSVVATSPD KLEECKWELE 

       250        260        270        280        290        300 
ADTERFIKTI EEIIYPYAWG EYNVLILPPS FPYGGMENPV FTFATPSIIS KDRENVDVIA 

       310        320        330        340        350        360 
HELAHSWSGN LVTSASWEHF WLNEGWTVYL ERRILASLHG EKYRHFSAII GWKALRDSVE 

       370        380        390        400        410        420 
HYSHDHEFTK LVPNLKGEDP DDAFSTIPYE KGFNFLFHLE NLVGKEKFDR FIPHYFTTFK 

       430        440        450        460        470        480 
GKSLDSYDFK ATLLDFFKSD AEASRLLQEL DWDSWFYKPG LPPKPEFDTS LADVVYELAG 

       490        500        510        520        530        540 
KWRSLPESPF QPQPSDIQGL TANQIVVFLE QILLFERPLT AELSKLMGEV YGLTGSENIE 

       550        560        570        580        590        600 
VANLYLQVGL KAADKSVIGP TTDLLGRIGR MKFVRPLYRA LQKVDRQVAI DTFEKHKDFY 

       610 
HPICRGMVEK DLFGKKDA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACD01000100 Genomic DNA. Translation: EAA58321.1. Different initiation.
RefSeqXP_663416.1.

3D structure databases

HSSPHSSP built from PDB template 1HS6 based on UniProtKB P09960.
SMRQ5B0W8. Positions 7-612.
ModBaseSearch...

Genome annotation databases

GeneID2871086.
KEGGani:AN5812.2.

Enzyme and pathway databases

BRENDA3.3.2.6. 3859.

Family and domain databases

InterProIPR016024. ARM-type_fold.
IPR012777. Leuk_A4_hydro_aminopept.
IPR001930. Peptidase_M1.
IPR015211. Peptidase_M1_C.
IPR014782. Peptidase_M1_N.
[Graphical view]
PANTHERPTHR11533. Peptidase_M1. 1 hit.
PfamPF09127. Leuk-A4-hydro_C. 1 hit.
PF01433. Peptidase_M1. 1 hit.
[Graphical view]
PRINTSPR00756. ALADIPTASE.
TIGRFAMsTIGR02411. leuko_A4_hydro. 1 hit.
PROSITEPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLKHA4_EMENI
AccessionPrimary (citable) accession number: Q5B0W8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: February 9, 2010
This is version 36 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents