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Q5B0P4

- Q5B0P4_EMENI

UniProt

Q5B0P4 - Q5B0P4_EMENI

Protein

3-isopropylmalate dehydratase

Gene

AN5886.2

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.UniRule annotation

    Catalytic activityi

    (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. 3-isopropylmalate dehydratase activity Source: UniProtKB-EC
    2. 4 iron, 4 sulfur cluster binding Source: InterPro
    3. homoaconitate hydratase activity Source: ASPGD
    4. isomerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. cellular response to farnesol Source: ASPGD
    2. leucine biosynthetic process Source: ASPGD
    3. lysine biosynthetic process via aminoadipic acid Source: ASPGD

    Keywords - Molecular functioni

    IsomeraseImported, LyaseUniRule annotation

    Keywords - Biological processi

    Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Leucine biosynthesisUniRule annotation

    Enzyme and pathway databases

    UniPathwayiUPA00048; UER00071.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-isopropylmalate dehydrataseUniRule annotation (EC:4.2.1.33UniRule annotation)
    Alternative name(s):
    Alpha-IPM isomeraseUniRule annotation
    Isopropylmalate isomeraseUniRule annotation
    Gene namesi
    ORF Names:AN5886.2Imported, ANIA_05886Imported
    OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)Imported
    Taxonomic identifieri227321 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000000560: Chromosome I

    Subcellular locationi

    GO - Cellular componenti

    1. 3-isopropylmalate dehydratase complex Source: InterPro

    Interactioni

    Protein-protein interaction databases

    STRINGi162425.CADANIAP00007148.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aconitase/IPM isomerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0065.
    HOGENOMiHOG000226972.
    KOiK01702.
    OMAiCVIEFAG.
    OrthoDBiEOG7W41M9.

    Family and domain databases

    Gene3Di3.20.19.10. 1 hit.
    3.30.499.10. 3 hits.
    3.40.1060.10. 1 hit.
    HAMAPiMF_01026. LeuC_type1.
    MF_01031. LeuD_type1.
    InterProiIPR004430. 3-IsopropMal_deHydase_lsu.
    IPR004431. 3-IsopropMal_deHydase_ssu.
    IPR012235. 3-IsopropMal_deHydtase_ssu/lsu.
    IPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
    IPR015937. Acoase/IPM_deHydtase.
    IPR001030. Acoase/IPM_deHydtase_lsu_aba.
    IPR015928. Aconitase/3IPM_dehydase_swvl.
    IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
    IPR018136. Aconitase_4Fe-4S_BS.
    IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
    [Graphical view]
    PANTHERiPTHR11670. PTHR11670. 1 hit.
    PfamiPF00330. Aconitase. 1 hit.
    PF00694. Aconitase_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001418. ACN. 1 hit.
    PRINTSiPR00415. ACONITASE.
    SUPFAMiSSF52016. SSF52016. 1 hit.
    SSF53732. SSF53732. 1 hit.
    TIGRFAMsiTIGR00170. leuC. 1 hit.
    TIGR00171. leuD. 1 hit.
    PROSITEiPS00450. ACONITASE_1. 1 hit.
    PS01244. ACONITASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5B0P4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPGADRKPKT LYDKVFDHHI VNEQEDGTVL IYIDRHLVHE VTSPQAFEGL    50
    KNANRKVRRP DCTLVTVDHN IPTSSRKNFK NVEQFIEEND SRLQCSTLEE 100
    NVKDFGLTYF GMDDKRQGIV HVIGPEQGFT LPGTTVVCGD SHTSTHGAFG 150
    ALAFGIGTSE VEHVLATQTL ITRRSKNMRV QVDGELPAGV TSKDVVLHII 200
    GLIGTAGGTG CVIEFCGSVI RGLSMEARMS MCNMSIEGGA RAGMVAPDET 250
    TFEYLKGRPL APKYDSAEWK KAVSYWSSLA SDEDAVYDKT ILIDAKDIVP 300
    TISWGTSPQD VVPITGVVPG PDDFEDEARK AACKRALEYM GLTAGTPMKD 350
    VTVDKVFIGS CTNSRIEDLR AAANVVRGKK VASNIKRAMV VPGSGLVKQQ 400
    AEAEGLDKIF IDAGFEWREA GCSMCLGMNP DILSPQERCA STSNRNFEGR 450
    QGAGGRTHLM SPAMAAAAAI VGKLADVREH IAESPRLGKV QPKVDVKPEA 500
    EDVDTEEELD HILDQPADNE PHTNTHTPAT TSAGLPKFTT LKGIAAPMDR 550
    SNVDTDAIIP KQFLKTIKRT GLGSALFYEL RYKDGQEDPS FILNQGIYRN 600
    SKILVVTGPN FGCGSSREHA PWALLDFGIK CVIAPSFADI FFNNTFKNGM 650
    LPVVIPDQAV LEKIADEARA GREVEVDLVN QEIKDEAGNK LASFDVDAFR 700
    KHCLINGLDD IGLTLQMEDK IAKFEAKRTL DTPWLDGKAY LKRGRTGGSN 750
    MVKAAPVPKT NRGDVKGEPL EW 772
    Length:772
    Mass (Da):84,105
    Last modified:April 26, 2005 - v1
    Checksum:i06E769007FB6BD14
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BN001301 Genomic DNA. Translation: CBF70635.1.
    AACD01000100 Genomic DNA. Translation: EAA58395.1.
    RefSeqiXP_663490.1. XM_658398.1.

    Genome annotation databases

    EnsemblFungiiCADANIAT00007148; CADANIAP00007148; CADANIAG00007148.
    GeneIDi2870766.
    KEGGiani:AN5886.2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BN001301 Genomic DNA. Translation: CBF70635.1 .
    AACD01000100 Genomic DNA. Translation: EAA58395.1 .
    RefSeqi XP_663490.1. XM_658398.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 162425.CADANIAP00007148.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADANIAT00007148 ; CADANIAP00007148 ; CADANIAG00007148 .
    GeneIDi 2870766.
    KEGGi ani:AN5886.2.

    Phylogenomic databases

    eggNOGi COG0065.
    HOGENOMi HOG000226972.
    KOi K01702.
    OMAi CVIEFAG.
    OrthoDBi EOG7W41M9.

    Enzyme and pathway databases

    UniPathwayi UPA00048 ; UER00071 .

    Family and domain databases

    Gene3Di 3.20.19.10. 1 hit.
    3.30.499.10. 3 hits.
    3.40.1060.10. 1 hit.
    HAMAPi MF_01026. LeuC_type1.
    MF_01031. LeuD_type1.
    InterProi IPR004430. 3-IsopropMal_deHydase_lsu.
    IPR004431. 3-IsopropMal_deHydase_ssu.
    IPR012235. 3-IsopropMal_deHydtase_ssu/lsu.
    IPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
    IPR015937. Acoase/IPM_deHydtase.
    IPR001030. Acoase/IPM_deHydtase_lsu_aba.
    IPR015928. Aconitase/3IPM_dehydase_swvl.
    IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
    IPR018136. Aconitase_4Fe-4S_BS.
    IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
    [Graphical view ]
    PANTHERi PTHR11670. PTHR11670. 1 hit.
    Pfami PF00330. Aconitase. 1 hit.
    PF00694. Aconitase_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001418. ACN. 1 hit.
    PRINTSi PR00415. ACONITASE.
    SUPFAMi SSF52016. SSF52016. 1 hit.
    SSF53732. SSF53732. 1 hit.
    TIGRFAMsi TIGR00170. leuC. 1 hit.
    TIGR00171. leuD. 1 hit.
    PROSITEi PS00450. ACONITASE_1. 1 hit.
    PS01244. ACONITASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139Imported.
    2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
      Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
      , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
      Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139Imported.
    3. "The 2008 update of the Aspergillus nidulans genome annotation: A community effort."
      Russo Wortman J., Mabey Gilsenan J., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J.M., Durek P., Espeso E., Fekete E., Flipphi M., Garcia Estrada C.
      , Geysens S., Goldman G., de Groot P.W.J., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A.K.W., Kim J-M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., MacCabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Posci I., Punt P.J., Ram A.F.J., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van der Vondervoot P.J.I., de Vries R.P., Walton J., Xiang X., Xiong Y., Ping Zeng A., Brandt B.W., Cornell M.J., van den Hondel C.A.M.J.J., Visser J., Oliver S.G., Turner G.
      Fungal Genet. Biol. 46:S2-S13(2009)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: FGSC A4Imported.

    Entry informationi

    Entry nameiQ5B0P4_EMENI
    AccessioniPrimary (citable) accession number: Q5B0P4
    Secondary accession number(s): C8UZW6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 26, 2005
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3