Reviewed, UniProtKB/Swiss-Prot Q5B0F5 (MTLD_EMENI)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
      Short name=M1PDH
      Short name=MPDH
      Short name=MPD
    EC=1.1.1.17

Gene names

Name:	mpdA
ORF Names:	AN5975

Organism

Emericella nidulans (Aspergillus nidulans) [Complete proteome]

Taxonomic identifier

162425 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › Emericella

Protein attributes

Sequence length	386 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NAD(H)-dependent interconversion of D-fructose 6-phosphate and D-mannitol 1-phosphate in the mannitol metabolic pathway By similarity.
Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 386	386	Mannitol-1-phosphate 5-dehydrogenase		PRO_0000371527
Regions
	Nucleotide binding	4 – 15	12	NAD By similarity
Sites
	Active site	211	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5B0F5-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 0E174D9C8F58C5E5	FASTA	386	43,102
	10 20 30 40 50 60 MGKAIHFGGG NIGRGFVGEF LHEAGYEVVF VDVVDDLITS IQNTPSYEIT EISEDGEKTK 70 80 90 100 110 120 KITNYRALNS KSHEADVVQE IATADIVTCA VGPRVLQFIA PVIAKGLESR NVSTPLTVIA 130 140 150 160 170 180 CENAINATDT LRGHIEKKTK PEIISERAVF ANCAIDRIVP NQPPNNGLNV RIEKYWEWVV 190 200 210 220 230 240 EQTPFKEKGV AHPNVSAIHW VDKLDPYIER KLFTVNTGHA TTAYYGHLAG KKTIADALHD 250 260 270 280 290 300 PKIRENVHKV LDETASLIIN KHGISEQEQK EYVDKIISRI SNPYLEDGVE RVGRAPLRKL 310 320 330 340 350 360 SRNERFIGPA SQLAERGLKF DALLGAIEQA LRFQNVEGDE ESKELAKILK EKTAEEATSE 370 380 LTELEKDHPL YSHVLERVRT VQQESK

References

[1]

"Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae." Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H. , Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L., Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W. Nature 438:1105-1115(2005) [PubMed: 16372000] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FGSC 4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACD01000102 Genomic DNA. Translation: EAA57724.1.
RefSeq	XP_663579.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2870882.
KEGG	ani:AN5975.2.
Family and domain databases
InterPro	IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR000669. Mannitol_DH_core. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_EMENI

Accession

Primary (citable) accession number: Q5B0F5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 5, 2009
Last sequence update:	April 26, 2005
Last modified:	September 22, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)